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October 15, 2013 (Vol. 33 , No. 18)

Electrophysiology Platform

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Molecular Devices

The IonWorks Barracuda® Plus system is an automated patch-clamp system that is designed to produce wide assay windows and stable ionic currents, enabling protocols to probe the use-dependent nature of ion channel drug candidates. Use-dependent drugs are sought after as they specifically target excitable cells that are exhibiting high levels of activity. The IonWorks Barracuda Plus system may be used to generate dose-response curves in single wells, which can reduce running costs and increase throughput. Compound additions can be made to wells in a 384-well PatchPlate™, generating up to 384 dose-response curves in 30–45 minutes.

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