The Q5™ high-fidelity DNA polymerase can provide high- fidelity amplification while also offering amplification across a range of amplicons, including those that are GC- and AT-rich. This polymerase is fused to the processivity-enhancing Sso7d DNA binding domain, which can improve fidelity, speed, and performance reliability (amplifying targets up to 20 kb long with extension times as low as 10 seconds per kb).