StarDrop 5.5 introduces MPO Explorer, a module that provides a means of guiding strategic decisions in research programs. It can help identify the key properties and selection criteria with which to select compounds with an improved chance of success by developing and validating multiparameter scoring profiles. The most important property criteria can be highlighted, focusing experimental resources. The module also tests if specific criteria in a scoring profile may be artificially distorting the selection of compounds. These modules capabilities are supported by enhancements to StarDrop, including new data visualization features such as 3D scatter and chemical space plots. In addition, StarDrop’s R-group analysis tool has been extended to perform matched pair analysis.