The Plate Auditor™ is a noninvasive tool for identification of precipitate and empty wells in compound and screening plates. The new Plate Auditor is the result of a collaboration with the Scripps Research Institute. It is designed to evaluate the quality of microplate-based compound samples for precipitation and liquid volume prior to use in compound management and high-throughput screening activities. The system analyzes plates to automatically verify sample integrity, thus eliminating the need for extensive manual quality control.