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January 15, 2014 (Vol. 34 , No. 2)

CMOS Camera for Fluorescence Microscopy

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QImaging

The optiMOS camera for fluorescence microscopy, as a CMOS (complementary metal-oxide semiconductor) device, presents an alternative to cameras that rely on traditional CCD (charge-coupled device) technology. With a frame rate 10 times faster than the typical CCD and less than 2e− of electronic noise, optiMOS is designed to capture fast cellular dynamic events without compromising sensitivity. In addition, as a 2.1-megapixel device, optiMOS can achieve a field of view 45% percent larger than a standard 1.4-megapixel fluorescence CCD camera. With such capabilities, optiMOS can be used to capture fleeting cellular events such as membrane dynamics, protein and lipid trafficking, and ion transport.

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