The Zymo-Spin ChIP Kit is designed to streamline and accelerate chromatin immunoprecipitation (ChIP). With its new protocol, the kit can accomplish efficient cross-linking, shearing, and immunoprecipitation of protein-chromatin complexes regardless of the mammalian cell type used. The Zymo-Spin ChIP Kit includes high-sensitivity Protein A magnetic beads that are designed for rapid selection of targeted complexes. The kit also includes a micro-elution spin column, which is meant to provide high-yield purification of ChIP DNA in ≥6 µL. By using the kit’s procedure, users can prepare enriched DNA that is suitable for subsequent analysis including end-point and quantitative PCR, ChIP-Seq library preparation, and next-generation sequencing-based applications.