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May 15, 2012 (Vol. 32 , No. 10)

Cardiotoxicity Screening

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Molecular Devices

The ScreenWorks® Peak Pro™ analysis module for the FLIPR® Tetra system analyzes multipeak calcium oscillation responses of cells—in particular beating cardiomyocytes—to characterize cardiotoxic and cardioactive compounds during a high-throughput screen. ScreenWorks Peak Pro analysis module allows access to measurement of cardiomyocyte beat rate, as well as temporal characteristics of peaks including rise, decrease, and amplitude. The system can help users estimate efficacy and dosing of a drug candidate prior to progression into clinical studies.

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