FLIPR® Calcium 6 assay kits address a range of GPCR and ion channel targets. Combining a fluorophore with quench technology, the dye offers a high quantum yield, delivering a good signal window, which enables researchers to monitor low-responders including biorelevant reactions from endogenous, primary, or stem cell targets. FLIPR 6 Calcium assay kits provide a method for detecting intracellular calcium changes in a homogeneous assay format. The dye is more resistant to anion-exchange proteins, enabling measurement with low probenecid, an exchange inhibitor, when studying cell lines containing an organic anion transporter.