The Cellmate Mk9 system is designed to automate the manufacturing processes associated with production of vaccines. The processes to which the Cellmate MK9 can be applied use adherent cell-based methods in roller bottles and T-flasks within a Class 100 laminar airflow cabinet. The system, which can be UL certified, includes an in-line particle counter that can be used to monitor nonviable particle loading in the processing area. Such monitoring can help address increasing demands from regulators for assurance about environmental quality. Cellmate Mk9 supports the OPC interoperability standard; Cellmate software retains 21 CFR Part 11 compliance; and the manufacturer supports IQ and OQ.