Related to Appreciating the Art of Assay Development

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• Bioluminescent Enzyme
• Promega
• The NanoLuc™ luciferase can provide new capabilities in reporter assays with the potential to aid with biologically complex applications that require greater sensitivity. It is small in size, allowing for viral delivery and protein fusion applicati
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• Microplate Reader
• BioTek Instruments
• Synergy™ NEO HTS multimode microplate reader is tailored for smaller cell-based screening assays. Synergy NEO includes multiple parallel detectors to decrease measuring time, and filter-based optics for live-cell assays. The Hybrid Technology™ foun
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• Assay Plate
• PerkinElmer
• The 96-well cellular label-free assay plate for the EnSpire® label-free multimode plate reader platform is designed to support basic life science research as well as assay development applications. The plate requires no assays; each well of th
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• Microplate Stacker
• BioTek Instruments
• The BioStack3 microplate stacker features a dual-plate carrier and rotational wrist to move plates from the source stack to the instrument and back to the destination stack, keeping two plates in process. BioStack3 is designed to provide increased
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• Cell-Signaling Assays
• Bio-Rad
• Bio-Plex Pro cell-signaling assays are designed for detecting phosphorylated and total proteins involved in key intracellular signaling pathways. The 34 magnetic bead–based immunoassays (23 phosphoprotein and 11 total protein targets) have been ref
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• Fatty Acid Oxidation Reagent
• Seahorse Bioscience
• The XF Palmitate-BSA FAO Reagent, an aqueous solution that can be readily absorbed and utilized by cells, can help with fatty acid oxidation (FAO) assays and works well for use in cell-based XF FAO assays. This standardized, quality-controlled, rea
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• Autoantibody Assay Kits
• Genalyte
• Assays for the Maverick™ detection system are now available. The Maverick ENA 4 and ENA 6 assay kits simultaneously screen for several common autoantibodies found in autoimmune connective tissue disorders, such as systemic lupus erythematosus. Thei
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• Compound Quality Control
• Brooks
• The Plate Auditor™ is a noninvasive tool for identification of precipitate and empty wells in compound and screening plates. The new Plate Auditor is the result of a collaboration with the Scripps Research Institute. It is designed to evaluate the
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• Nitrocellulose Membranes
• GE Healthcare Life Sciences
• The Whatman™ FF High Performance (HP) membrane is a diagnostic membrane that enables line separation and reproducible results for the detection of target molecules in liquids such as water, urine, blood, and saliva. The target molecules may include
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• Single-Cell Gene Expression Assay
• NanoString Technologies
• A single-cell gene expression application is now available that can provide researchers with a flexible and sensitive approach to discovering differences in cell-to-cell gene expression profiles. The nCounter® Single-Cell Gene Expression assay
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• Target Enrichment
• Roche
• Multiple new SeqCap EZ Library target enrichment products are now available. SeqCap EZ Exome Plus Library adds up to 50 Mb of custom targets to the existing 64 MB EZ Exome v3 products. SeqCap EZ Exome +UTR Library offers an exome enrichment design
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• Reporter Kits
• Horizon Discovery
• Available through a partnership with Promega, X-MAN™ reporter kits can enable researchers to apply cell-based assays that directly interrogate critical biological activities at endogenous expression levels. The X-MAN reporter kits are designed for
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• Assay Reader Module
• Tecan
• The Infinite® F200 PRO multimode reader now features an AlphaScreen® module for AlphaScreen and AlphaLISA® assays. Offering sensitivity for screening and research, the new option works well for low- and medium-throughput applications
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• Transporter Knockout Cell Lines
• Sigma-Aldrich
• MDR1, BCRP, and MRP2 transporter knockout cell lines are now available that enable identification of substrate/transporter interactions without chemical inhibitors or knockdown RNAi technology. The knockout cell lines are available as assay-ready p
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• Incubator for Cell-Based Research
• Thermo Fisher Scientific
• The Cytomat® 10 is an automated incubator and storage module for high-capacity cell growth and assay incubation. It offers environmental control and can be integrated with existing automated assay hardware. A thermal disinfection method can ge
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• Sample Solutions
• Artel
• A line of 100% DMSO-based sample solutions is now available for use with the MVS® Multichannel verification system that can provide users with the ability to measure the accuracy and precision of volumes of DMSO dispensed into micro-well plate
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• HCS Station
• Olympus
• The scan^R 2.4 high-content screening station is based upon the IX3 inverted microscope frame. The updated screening station can now be incorporated with the fully automated IX83, combining a modular frame design with scan speed. This new system ca
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• Retinoic Acid Assay Kits
• INDIGO Biosciences
• Retinoic acid receptor (RAR) gamma and retinoic-acid orphan receptor (ROR) gamma assay systems are now available in cell-based assay kits that enable researchers to obtain data in four steps: thaw, feed, dose, read. The RORγ and RARγ assay kits can
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• Calcium Assay Kits
• Molecular Devices
• FLIPR® Calcium 6 assay kits address a range of GPCR and ion channel targets. Combining a fluorophore with quench technology, the dye offers a high quantum yield, delivering a good signal window, which enables researchers to monitor low-respond