Related to Human Hepatocytes in HTS DDI Studies

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• Microplate Washer
• BioTek Instruments
• The 405™ Touch microplate washer features a high-resolution, LED-backlit touchscreen interface that aids in protocol creation and implementation as well as instrument maintenance, and supports all gloved environments. Additionally, it includes two
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• Cardiomyocyte-Beat Monitor
• Roche
• The xCELLigence RTCA Cardio Instrument provides predictive information about cardiac safety during drug development by measuring cardiomyocyte beating under physiological conditions in cell culture. Through noninvasive, real-time monitoring in 96-w
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• Cytotoxicity Assay
• Promega
• The Mitochondrial ToxGlo™ assay helps produce the predictive data necessary to assess mitochondrial function in the context of other cytotoxic events. Based on the differential measurement of biomarkers associated with changes in cell membrane inte
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• Bioluminescent Enzyme
• Promega
• The NanoLuc™ luciferase can provide new capabilities in reporter assays with the potential to aid with biologically complex applications that require greater sensitivity. It is small in size, allowing for viral delivery and protein fusion applicati
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• Microplate Reader
• BioTek Instruments
• Synergy™ NEO HTS multimode microplate reader is tailored for smaller cell-based screening assays. Synergy NEO includes multiple parallel detectors to decrease measuring time, and filter-based optics for live-cell assays. The Hybrid Technology™ foun
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• ssDNA Quantitation
• Promega
• The QuantiFluor™ ssDNA system is designed for highly sensitive quantitation of single-stranded DNA (ssDNA). The QuantiFluor ssDNA dye enables quantitation of small amounts (as little as 200 pg per well) of ssDNA in solution. For low-concentration s
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• Microplate Stacker
• BioTek Instruments
• The BioStack3 microplate stacker features a dual-plate carrier and rotational wrist to move plates from the source stack to the instrument and back to the destination stack, keeping two plates in process. BioStack3 is designed to provide increased
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• Compound Quality Control
• Brooks
• The Plate Auditor™ is a noninvasive tool for identification of precipitate and empty wells in compound and screening plates. The new Plate Auditor is the result of a collaboration with the Scripps Research Institute. It is designed to evaluate the
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• Resistant-to-Inhibitor Master Mixes
• Promega
• The GoTaq® Probe PCR Master Mix, GoTaq Probe 1-Step RT-qPCR system, and GoTaq Probe 2-Step RT-qPCR system are ready-to-use, 2x master mixes that can simplify the preparation of reactions for qPCR using hydrolysis probe detection. They are desi
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• Low-Volume Dispensers
• BioTek Instruments
• The EL406™ microplate washer dispensers and MultiFlo™ microplate dispensers are capable of dispensing down to 500 nL via their respective peri-pump dispensing modes. The EL406 combines microplate washing with peristaltic and syringe pump dispensing
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• DNA Isolation
• Tecan
• The Freedom EVO®-HSM workstation provides walkaway extraction of gDNA from large-volume blood samples using Promega’s ReliaPrep™ large-volume HT gDNA isolation system. The workstation is designed to streamline biobanking workflows, offering on
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• Reporter Kits
• Horizon Discovery
• Available through a partnership with Promega, X-MAN™ reporter kits can enable researchers to apply cell-based assays that directly interrogate critical biological activities at endogenous expression levels. The X-MAN reporter kits are designed for
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• Bisulfite Conversion System
• Promega
• The MethylEdge™ bisulfite system offers a method for performing bisulfite conversion and DNA clean-up while maintaining DNA integrity to provide intact, converted DNA for a range of sensitive applications. MethylEdge requires small amounts of input
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• Protein Proteolysis Mix
• Promega
• Trypsin/Lys-C mix is a combination of Trypsin Gold and rLys-C proteases. The mix increases peptide generation with in-solution protein digestion and can work with difficult-to-digest proteins. Enhanced proteolytic activity achieved through use of T