Related to Proteome Sciences and Buck Institute Ally on MS-Based Anti-Estrogen Therapy Resistance Assays

• With USPTO Report Near, Comments Reflect Confirmatory Diagnostic Testing Divide
  Dx makers would like to keep patent protection, but patient groups say it stifles broader access to genetic tests at lower cost.
  
• Know Your Enzyme Forms
  Study demonstrates using an uncompetitive inhibitor as a probe to monitor the conformational change induced by compound binding with an HTRF assay.
  
• New Luciferins
  Researchers describe a rapid method to synthesize D-luciferin along with a novel set of electronically modified analogues.
  
• Reducing Endocytosis Assay
  Researchers describe a new method of studying the endocytosis and recycling of cell surface proteins.
  
• Biographies for Compounds
  Researchers demonstrate the value of a tool that compares compounds solely on the basis of their bioactivity for virtual screening.
  
• End-Running Cancer Resistance to Targeted Therapies
  Overcoming resistance may require an assault on multiple fronts.
  
• Accessible TALENs
  The FLASH system is a rapid and cost-effective method for large-scale assembly of transcription activator-like effector nucleases.
  
• Inhibitors That Put A Kink in Abl's Helix
  Researchers develop a direct-binding assay that enables the detection of allosteric inhibitors, which can suppress a cellular enzyme that contributes to leukemia.
  
• Synthetic Degrons Play The N-End Game
  The Boc₃Arg moiety may provide a general strategy to construct inhibitors that induce targeted protein degradation.
  
• ATP Gets Smart/Absorbing BLA Assay
  Researchers propose a fluorescent probe for adenosine triphosphate assay and describe a synthesis of a chromogenic cephalosporin for β-lactamase assay.
  
• Binding MoA by DPI
  Researchers investigate the application of dual-polarization interferometry (DPI) as a method for the real-time characterization of low molecular weight ligands.
  
• 15 Breast Cancer Drugs in the Pipeline Right Now
  Which candidates are on their way from the lab to the medicine chests of thousands?
  
• Tripping The Light Fantastic: New Reporter System
  This study outlines an approach to improved use of reporter genes in high-throughput screening.
  
• Look, No Label! Label-Free MST
  Two articles report on two methods that provided different levels of information on the differentiation of binding sites available on protein targets of interest.
  
• 7 Biotech Trends for the Coming Year
  What does 2013 hold for the industry?
  
• 10 Predictions That Will Transform Healthcare
  Peer into GEN's crystal ball for a glimpse of what's to come.
  
• Literature Review: Mega-Selection
  Researchers present a method that uses combinatorial antibody libraries to endow cells with new binding energy landscapes to regulate their phenotypes.
  
• Literature Review: ELISA—Detected Through A Quick Glance
  Researchers provide an assay chemistry that allows for a direct visual scoring of an ELISA result to detect protein analytes at ultralow concentrations.
  
• Literature Review: Protein—Now You See It, Now You Don't
  Researchers describe a system for the rapid and complete degradation of proteins in mammalian cells.
  
• Literature Review: BioMAP—Antibiotic Fingerprints
  Researchers show that bioactivity fingerprinting can help with profiling antibiotic lead compounds.