Presents an Educational and
Informative Audio Webinar
Advances
in Compound
Identification Using
Metabolomics
Original Broadcast Date: Wednesday, September 23, 2009
Metabolomics has been described as the systematic study of the unique, small molecule chemical fingerprints that specific cells produce. The metabolome is composed of the end products of gene expression. It is a summation of genomic, proteomic, and environmental influences.
The metabolome has become a rich source of unbiased information on gene function, providing insight into the real-time biologic impact of genes and their protein products. Unbiased metabolite analysis has become a standard tool for uncovering diagnostic biomarkers, or targets for drug discovery, that arise rapidly after disease onset.
Primary endogenous human metabolites are limited to about 3,000 compounds; however, secondary human metabolites increase the number of metabolites. The number of primary and secondary metabolites is still less than the number of genes and proteins. The metabolome is therefore, at one level, more tractable than the genome or proteome. However, metabolites are much more chemically diverse than either proteins or genes, and their concentration dynamic ranges are wide as well, presenting formidable challenges when searching for metabolomic biomarkers.
This webinar explores state-of-the-art mass spectrometry and MS/MS techniques for routine and novel compound identification of metabolites discovered using metabolomics.
Who Should Attend?
- Systems biologists
- Academic and industrial biomarker investigators
- Drug discovery scientists involved in target identification
- Cell biologists in the pharmaceutical or biopharmaceutical industries
- Mass spectroscopists working in life science laboratories
Speakers
Paul R. West, Ph.D., Director, BioAnalytical Chemistry, Stemina Biomarker Discovery, will discuss de novo chemical structure determination using high-resolution LC/MS and other techniques.
Gary Siuzdak, Ph.D., Senior Director, Scripps Center for Mass Spectrometry, will discuss Metlin and the Metlin MS/MS library. Metlin contains more than 23,000 endogenous, exogenous, and theoretical metabolites. These libraries are used for identification of metabolites and complete unknowns.
Steven Fischer, Senior Applications Chemist, Agilent Technologies, will discuss the typical metabolomics work flow and the need for and purpose of compound identification in metabolomics research.
Your host for this webinar will be John Sterling, Editor in Chief of Genetic Engineering & Biotechnology News. A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelists.
Available for On-Demand Viewing!
PANELISTS
|
Paul R. West, Ph.D. |
|
Gary Siuzdak, Ph.D. |
|
Steven Fischer |
MODERATOR
|
John Sterling |
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