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GEN News Highlights : Jan 8, 2007

Cellzome Publishes Quantitative Proteomics Approach

Physio-chemical approach may turn proteomics from a discovery tool into a quantitative biological science.

Cellzome published a paper that it believes could turn proteomics from a discovery tool into a quantitative biological science. The study, detailing an approach to predict proteotypic peptides, was published in the January issue of Nature Biotechnology.

In collaboration with the Institute of Systems Biology and the University of California, Los Angeles, Cellzome mined its proteomic database to systematically investigate the physico-chemical principles governing mass spectrometric peptide sequencing. The team used this information to develop software that enabled the genome-wide prediction of proteotypic peptides. The use of proteotypic peptides provides a new approach to protein identification and protein quantification.

Cellzome believes that this information can be transformed into a computational tool that enables the genome-wide prediction of proteotypic peptides from any DNA or protein sequence.