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GEN News Highlights : Sep 18, 2006

Open Biosystems Helps Drexel University Knock Out Genes

Open Biosystems reported that Drexel University is using its Expression Arrest™ shRNAmir retroviral library to identify and analyze genes associated with Alzheimer’s disease. The Alzheimer’s study is in the final phase of a six-year process expected to be complete by end of the fall.

Taking advantage of proven short hairpin design, researchers are utilizing Open Biosystems’ Expression Arrest shRNAmir retroviral library to help increase the efficiency and specificity of gene knockdown and reduce off-target effects.

“We evaluated many different technologies, and the shRNAmir technology was the ideal match for our project because of its affordability, comprehensive coverage of the human genome, multiple avenues of delivery to target cells, and significant improvement to our efficiency in targeting genes. These qualities are allowing us and many other investigators to perform experiments that were previously impossible,” says Aleister Saunders, Ph.D., professor of bioscience and biotechnology at Drexel University.