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GEN News Highlights : Feb 4, 2014
NIH Coaxes Big Biopharma to AMP Up Drug Development
The NIH today said it is joining 10 biopharma giants and several nonprofit groups today to launch the Accelerating Medicines Partnership (AMP), whose partners will spend more than $230 million over five years through the alliance-building Foundation for the NIH (FNIH) on its first of several three- to five-year, milestone-driven pilot projects designed to speed up the validation of disease targets, and thus bring new drugs to market faster.
The 10 biopharmas include AbbVie, Biogen Idec, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Johnson & Johnson unit Janssen Research and Development, Merck & Co., Sanofi, and Takeda.
Nonprofit partners joining the FNIH include the Alzheimer’s Association, the American Diabetes Asociation, the Geoffrey Beene Foundation Alzheimer’s Initiative, the Lupus Foundation of America, the Pharmaceutical Research and Manufacturers Association (PhRMA), the Rheumatology Research Foundation, and USAgainstAlzheimer's.
The first pilot projects will focus on Alzheimer’s disease, type 2 diabetes, and the autoimmune disorders rheumatoid arthritis and systemic lupus erythematosus (lupus). The NIH said that the AMP aims to characterize biomarkers and distinguish biological targets of disease most likely to respond to new therapies.
Data and analyses generated through AMP projects will be made publicly available to the broad biomedical community.
“We are investing a great deal of money and time in avenues with high failure rates, while patients and their families wait. All sectors of the biomedical enterprise agree that new approaches are sorely needed,” NIH director Francis S. Collins, M.D., Ph.D., said in a statement.
The AMP has been more than two years in the making, using that time to bring together scientists in the public and private sectors, refine its goals, develop its strategy with support from the Boston Consulting Group, and develop a framework for scientific project and partnership management through the FNIH. The AMP's partners have developed research plans and have agreed to share costs, expertise, and resources.
The pilot projects include:
“The rich collection of curated and collated information in this portal will provide an opportunity to identify the most promising therapeutic targets for diabetes from the growing mountain of potentially relevant data,” according to the NIH.
Collaborative steering committees with representation from public- and private-sector partners will be established for each disease area to oversee the research plans. The steering committees will be managed by the FNIH under the direction of an AMP executive committee consisting of leaders from the NIH, industry, the FDA, and patient advocacy organizations.
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