Trovagene granted Duke University and Duke University Health Systems a nonexclusive license to incorporate nucleophosmin protein (NPM1) into research and clinical testing services for acute myelogenous leukemia (AML).
Mutations in an NPM1 gene are characteristic of 30% to 40% of the cases of AML, according to Trovagene. NPM1 is a protein involved in regulation of ribosome biogenesis, cell division, cell death, and other important processes, the firm explains.
“Use of NPM1 is part of the NCCN guidelines for the treatment of AML,” says Antonius Schuh, Ph.D., CEO. “Clinical and academic laboratories are increasingly interested in licensing this assay so they can offer it directly to their physicians for use in patient care.”
Within the U.S., Trovagene has granted nonexclusive sublicenses to offer mutation analysis of NPM1 as a laboratory service for the diagnosis and monitoring of patients with AML to Quest Diagnostics, LabCorp, Fairview Health Services, and Invivoscribe Technologies. Internationally, license holders include Münchner Leukamielabor in Munich, Germany and Skyline Labs in the Netherlands. In addition, Trovagene has granted a co-exclusive license to manufacture and sell NPM1 mutation kits to Asuragen and Ipsogen.