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GEN News Highlights : Aug 2, 2011

PhyNexus and BAC Combine Technologies for Small-Volume Protein Purification

Firms are offering CaptureSelect resins along with PhyTip column format.

PhyNexus and BAC are together launching a range of BAC’s CaptureSelect® ligands in PhyNexus’ PhyTip® column format. They are designed for parallel processing in an automated format.

The columns can be used with any of the manufacturer’s robotic liquid-handling platforms. Pure and highly concentrated samples obtained from the processing are ready for cell-based assays, analytics, or any desired functional test.

In addition, PhyTip columns set up a matrix of purification conditions. This allows researchers to scout for the best purification conditions, resulting in high yield and activity.

“BAC has created a unique and powerful platform for affinity purification with its range of CaptureSelect products,” comments Douglas Gjerde, Ph.D., CEO of PhyNexus, adding: “The availability of the CaptureSelect resins in the PhyTip column format provides additional flexibility to scientists who wish to determine the best purification conditions for their needs.”

BAC CaptureSelect products are affinity ligands created by a technology based on Camelid-derived single domain antibody fragments. The ligand is a 12 kD single domain fragment which comprises the 3 CDRs that form the antigen binding domain, efficiently produced by the yeast Saccharomyces cerevisiae.