Investigators Figure Out How Hematopoietic Stem Cells Survive in Hypoxic Conditions
Team describes transcriptional network that regulates HSC metabolism through glycolysis.!--h2>
Researchers have identified that hematopoietic stem cells (HSCs) utilize glycolysis instead of mitochondrial oxidative phosphorylation to meet their energy demands. This allows them to survive in low-oxygen microenvironments, a property that makes bone marrow transplantation so efficient.
UT Southwestern Medical Center scientists report their findings in Cell Stem Cell in a paper titled “The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche.”
The team used flow cytometry to identify a low mitochondrial activity/glycolysis-dependent subpopulation that houses the majority of hematopoietic progenitors and long-term HSCs (LT-HSCs). They demonstrated that Meis1 and Hif-1α are markedly enriched in LT-HSCs and that Meis1 regulates HSC metabolism through transcriptional activation of Hif-1α.
The investigators believe that the findings reveal an important transcriptional network that regulates HSC metabolism.