DNA Methylations and Histone Modifications: Links to Diseases
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Enal Razvi, Ph.D.
The focus of this GEN Market & Tech Analysis report is to present some of our recent industry tracking of the various DNA methylations and histone modifications documented in specific disease states.
Highlights of this report:
Specific examples of documented DNA methylations and histone modifications of specific genes are emerging.
Many of these modifications are being validated and evaluated for clinical utility.
These modifications of specific genes are demonstrated in various cancer classes, but also in diseases beyond oncology—hence, the reach of methylations and histone modifications appears to scale across many disease areas, thereby increasing their potential utility.
We have also characterized the sample types where these modifications are being tested, offering a glimpse into potential clinical implementations as well as sample preparation market opportunities to companies operating in these spaces.
Enal Razvi, Ph.D., conducted his doctoral work on viral immunology and subsequent to receiving his Ph.D. went on to the Rockefeller University in New York to serve as Aaron Diamond Post-doctoral fellow under Professor Ralph Steinman [Nobel Prize Winner in 2011 for his discovery of dendritic cells in the early-70s with Zanvil Cohn]. Subsequently, Dr. Razvi completed his research fellowship at Harvard Medical School. For the last two decades Dr. Razvi has worked with small and large companies and consulted for more than 100 clients worldwide. He currently serves as Biotechnology Analyst and Managing Director of SelectBio U.S. He can be reached at firstname.lastname@example.org.