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4 Tips for Choosing the Ideal Mass Spec Platform for In-Depth Proteomics Research
Combining MS approaches offers advantages over using a single MS technique.!--h2>
The dynamics of time, space, and concentration, as well as variability due to modifications and mutations of proteins make proteomics considerably more complex than genomics. Therefore several complementary mass spectrometry (MS) approaches are required to generate a complete picture of what a protein is, where it might be located, and how it is modified. For proteomics researchers looking to do more than identify and quantify an individual protein, or who want to elucidate their understanding of a single cellular compound, combining MS approaches offers advantages over a single MS technique.
We outline three techniques, and the MS systems utilized for them, that can be used individually or as a complementary approach. Because each of these techniques sheds slightly different insight into and information about the protein, collectively they help establish in-depth knowledge, not mere data. Choosing an MS vendor that supports all the necessary tools, including bioinformatics, helps achieve multidimensional analysis.
Pierre-Olivier Schmit and Jason S. Wood work at Bruker.
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