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10 Tips for Designing Peptides
These tips can help reduce common problems during peptide synthesis, purification, and handling.
The sequence of a peptide is the most critical factor that influences its biological activity. The sequence and amino acid composition also affect the synthesis outcome and purification as well as peptide solubility. For a peptide project to be viable, it is important that it is easy to synthesize to cut costs and convenient to handle for different applications in terms of stability and solubility. Most peptides of biological interest are derived from N-terminal, C-terminal, or internal sequences of native proteins. Peptides can also be designed de novo. The following tips should be taken into consideration whenever possible in the design of a peptide.
In conclusion, if the above guidelines are followed during peptide design, common problems during peptide synthesis, purification, and handling can be minimized.
Jyothi Thundimadathil, Ph.D., is a technical marketing associate at American Peptide Company.
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