Advertorial: Tosoh Bioscience

Tosoh Bioscience is a major supplier of chromatography products worldwide, particularly to the pharmaceutical, biotechnology, and chemical industries. The company is a division of Tosoh Corporation, a global chemical company with headquarters and manufacturing facilities in Japan.

TSKgel®, TOYOPEARL® products, and the EcoSEC® GPC System are used for the analysis, isolation, and purification of proteins, peptides, synthetic polymers, DNA, oligonucleotides, antibiotics, and other small molecular weight compounds. Our products are known for their ability to withstand high pressure, their robust chemical stability, and their superior performance for the recovery, concentration, and purification of biomolecules and macromolecules.

Markets Served

Tosoh Bioscience chromatography products are manufactured by Tosoh Corporation in Japan, with regional distribution offices worldwide providing sales and support to customers in pharmaceutical, biotechnology, and chemical industries.

• Tosoh Corporation (Bioscience Division) serves customers in Asia (except China)
• Tosoh Bioscience LLC serves customers in North and South America
• Tosoh Bioscience GmbH serves customers in Europe and Mid-East
• Tosoh Bioscience Shanghai Co., Ltd. serves customers in China
• Tosoh Asia PTE (Singapore) serves customers in India, South-east Asia, Oceania

Capabilities

Tosoh Bioscience offers a comprehensive line of TSKgel pre-packed HPLC columns for each of the major chromatography modes (SEC, IEC, RPC, NPC, HILIC, HIC, AFC), a dedicated GPC system, the EcoSEC GPC System, for semi-micro and high-throughput SEC measurements, ToyoScreen® process development columns, as well as Toyopearl and TSKgel bulk resins for laboratory-scale purifications and process chromatography.

Pre-packed columns containing TSKgel media are designed for the analysis of proteins, peptides, other biopolymers, and low molecular weight compounds. The packings in the columns are either silica-based or polymer-based material, in particle sizes ranging from 2 μm to 20 μm. Columns are available in analytical through preparative sizes, in stainless steel, PEEK®, or glass.

The same polymeric media used in TSKgel columns are also available in bulk. They are offered in particle sizes of 20 μm and 30 μm, for high-resolution purification protocols based on ion exchange and hydrophobic interaction chromatography.

Toyopearl resins have the same selectivity as the TSKgel resins and are hydrophilic, macroporous, bulk bioprocessing media made exclusively for large-scale chromatographic applications.

The media are stable over the pH range of 2–12 for normal operating conditions and pH 2–14 for cleaning conditions. The particle sizes are: 50–150 μm (coarse grade) for capture chromatography, 40–90 μm (medium grade) for economical purification, and 20–50 μm (superfine grade) for high performance polishing applications. Toyopearl media are available for hydrophobic interaction, ion exchange, affinity and size exclusion chromatography in large-scale processes.

ToyoScreen Process Development columns are method-development tools for convenient scale-up. These are easy-to-use, pre-packed columns containing the popular Toyopearl resins and provide a convenient, low-cost method for the evaluation of Toyopearl ligand chemistries.

The EcoSEC GPC System is a complete system for the analysis of polymers by GPC. The unit is ideal for semi-micro columns due to its low dead volume and as a result saves time, money, and valuable sample.