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2009

November 15, 2009 (Vol. 29, No. 20)
Pooled Genome-Wide shRNA Screening
Heather Holemon, Ph.D.
Victoria Rusakova
Transfection Market Clamors for Silver Bullet
Jonathan Witonsky
NBS Experiences Post-Acquisition Growth
Carol Potera
Oklahoma Seeks to Retain Local Research
Gail Dutton
Making the Most of Transfection Processes
Catherine Shaffer
Head Start Boosts Value of Stability Testing
Vicki Glaser
"Simplexity" of Flow Cytometry Technology
J.C. Mason, Ph.D.
Taking Multiplexing to the Next Level
K. John Morrow Jr., Ph.D.
Strategies for Companies Targeting GPCRs
James Netterwald, Ph.D.
Flow Cytometry's Expanding Niche
Richard A. Stein, M.D., Ph.D.
Improving and Enhancing the Use of Quantitative PCR
Kathy Liszewski
Sidebar: Industry Experts Share Flow Cytometry Insights
Cracking Down on Misinformation
Bruce F. Mackler, Ph.D., J.D.
Developments in Focused Kinase Libraries
Richard Hill, Ph.D.
Analytical Considerations in Formulation
Sian Estdale, Ph.D.
Dried Blood Spots for Toxicokinetic Studies
James C. Robbins, Ph.D.
Lee Goodwin, Ph.D.
Phillip Turpin, Ph.D.

November 1, 2009 (Vol. 29, No. 19)
Cellular-Signaling Pathway Signatures
Wendy Weatherford
Alexander Karasyov, Ph.D.
James Schwaber, Ph.D.
Frauke Rininsland, Ph.D.
Sparing Patients the Needle Remains a Priority
Bruce Carlson
Senesco Attempts to Exploit Cell Death
Carol Potera
Lilly Unveils Green Biotechnology Campus
Vicki Glaser
Search Intensifies for Diabetes Drugs
Nina Flanagan
Single-Use Systems Make Headway with Skeptics
Angelo DePalma, Ph.D.
Sample Prep Advances Extend Mass Spec
K. John Morrow Jr., Ph.D.
New Capabilities Fortify Biodefense Tools
Gail Dutton
Animal Imaging Transforms Development
Elizabeth Lipp
Third Option for Stem Cell Research Emerges
Kenneth C. Aldrich
Certainty Not Required for Inventorship
William L. Warren
S.Alex Cao, Ph.D.
Preserving the Integrity of Statistics
Zachary N. Russ
GEN's GREENbiopharma Conference Focuses on the Economic Rationales of Going Green in Biotech
Dual Scan Multiple Reaction Monitoring MS
Joanne Mather
Paul D. Rainville
Robert S. Plumb, Ph.D.
Applying Real-Time PCR to Strain Identification
Arun Apte
Using ClonePix FL to Assess Monoclonality
Julian F. Burke, Ph.D.
Christopher J. Mann, Ph.D.
Sky Jiang
Kerensa J. Klottrup, Ph.D.
Natalie Smithers, Ph.D.
Omee Ahmed
Shaken Bioreactors Provide Culture Alternative
Tibor Anderlei, Ph.D.
Christoph Cesana
Cedric Bürki
Maria De Jesus, Ph.D.
Markus Kühner
Florian Wurm
Rene Lohser
Gains Steadily Building in Biotech Sector
G.Steven Burrill

October 15, 2009 (Vol. 29, No. 18)
High-Resolution Melt Analysis Applications
Viresh Patel, Ph.D.
Firms Seek to Prove Cancer Stem Cell Hypothesis
Keith A. Markey, Ph.D.
Merrion Strives to Turn IV Drugs into Tablets
Carol Potera
High-Content Screening Surges Ahead
Vicki Glaser
Stem Cell Technologies Boost Regenerative Medicine
James Netterwald, Ph.D.
Enhancement of Cell Culture Techniques
Angelo DePalma, Ph.D.
Use of Microarrays Increasing Rapidly
Sophia Fox
qPCR Faces Growing Pains Head-On
Kathy Liszewski
Novel Tools Streamline Purification Process
K. John Morrow Jr., Ph.D.
Fighting Pancreatic Cancer's Intractable Nature
Patricia F. Dimond, Ph.D.
GEN's Cryptogram Challenge Solved
DTC Genomics & Leading-Edge Ethics
Chris MacDonald, Ph.D.
Cells That Get No Respect
Update on Evolving Regulatory Guidance
Bruce F. Mackler, Ph.D., J.D.
Assessment of Drug Interaction Potential
Igor Mezine, Ph.D.
Chris Bode, Ph.D.
Sid Bhoopathy, Ph.D.
Automated Cell Culture with 3-D Substrate
Nadia A. Badr
Brad Justice
Robin A. Felder, Ph.D.
Simulated Moving Bed Chromatography
Anthony Grabski, Ph.D.
Robert Mierendorf, Ph.D.

October 1, 2009 (Vol. 29, No. 17)
Studying the S-Glutathionylation of Proteins
Thomas G. Brock, Ph.D.
Micah Doty
Biosimilar Market Fails to Meet Projections
Bruce Carlson
Novasep Morphs Into Full-Service Company
Sophia Fox
Hong Kong Sees Opportunities with TCMs
Robert Yuan, Ph.D.
Advances in Quantitative Proteomics
Patricia F. Dimond, Ph.D.
Contract Manufacturing Demand Remains Strong
Cindy Liu
William Downey
Novel Approaches Simplify Sample Prep
Elizabeth Lipp
Protein Expression Poised for Reinvention
K. John Morrow Jr., Ph.D.
Venture Philanthropy Bets on Risky Projects
Jonathan Simons, M.D.
Laskers Honor Stem Cell & Cancer Research
New Assays Invigorate Biomarker Discovery
Catherine Shaffer
Written Descriptions: How Much Is Enough?
Courtenay C. Brinckerhoff
Economic Realities of Clusters
Michael Sable, Ph.D.
Optimizing CHO Cell Culture Conditions
Christopher A. Sellick, Ph.D.
Arfa R. Maqsood
Alexandra S. Croxford, Ph.D.
Alan J. Dickson, Ph.D.
Royston Goodacre, Ph.D.
Gill M. Stephens, Ph.D.
Cell-Counting Technologies Are Evolving
Clare Rogers
Erin Gatza, Ph.D.
Trials and Tribulations for Melanoma Drugs
Simos Simeonidis, Ph.D.

September 15, 2009 (Vol. 29, No. 16)
Live-Cell Luminescent Assays for GPCR Studies
Brock F. Binkowski, Ph.D.
Frank Fan, Ph.D.
Keith V. Wood, Ph.D.
Tests to Rapidly Diagnose Sepsis Essential
Aruna Rajan
Harry Glorikian
Symyx Technologies Ventures Into Novel Arena
Carol Potera
Karolinska Development Spins Off New Group
Sophia Fox
In Defense of Virtual Development Models
Greg Dombal
Lauren Sherman
3-D Cell Culture for Discovery & Bioprocess
Nina Flanagan
HPLC Advances for Biomolecular Analysis
Susan Aldridge, Ph.D.
Research Reveals the Influence of miRNA
Kathy Liszewski
Strategies for Successful Formulation
Angelo DePalma, Ph.D.
Vaccine Production Shifts to High Gear
Vicki Glaser
Metabolic Profiling Crucial to Unveiling Cellular Complexity
Richard A. Stein, M.D., Ph.D.
Quebec Eyes Biotech as Key Growth Sector
Vicki Glaser
3-D Cerebral Cortex Model
Agency Gains Regulatory Clout
Bruce F. Mackler, Ph.D., J.D.
Parvovirus B19 VLP Vaccine Manufacturing
Daniel A. Shelly, Ph.D.
Victor Van Cleave, Ph.D.
Deciphering the Process of Gene Evolution
Stability Testing for Protein Therapeutics
David Gregson, Ph.D.
Lindsay Cole, Ph.D.
Reproducible Dispensing of Live Cells
Sini Suomalainen

September 1, 2009 (Vol. 29, No. 15)
Sample Enrichment Technology Advances
Clotilde Teiling
Thomas Jarvie, Ph.D.
Access to Global Populations Speeds Trials
Douglas Peddicord, Ph.D.
EcoBiotics Scours Rainforest for Compounds
Carol Potera
Live-Cell Imaging Increases Impact on R&D
Gail Dutton
Innovation Marks Steady Growth of Asian Biotech
Gail Dutton
Peptide Therapies Coming Into Their Own
James Netterwald, Ph.D.
Next-Gen Sequencing Becoming Ubiquitous
Catherine Shaffer
Next-Gen Presents Array of Opportunities
Elizabeth Lipp
Streamlining Protein Sample Preparation
K. John Morrow Jr., Ph.D.
Bioprocess Monitoring Relies on Connectivity
Angelo DePalma, Ph.D.
Q&A on Sartorius Stedim Biotech/SAFC Deal
Searching for Appropriate Cancer Biomarkers
Amnon Gonenne, Ph.D.
Changing the Face of Clinical Medicine
K. John Morrow Jr., Ph.D.
MDx Hones In On Near-Patient Setting
Nina Flanagan
Personalized Medicine Realizing Its Promise
Edward Abrahams, Ph.D.
Timing Rules for Biological Deposits in Flux
Joseph Hsiao
Activism, Mendacity, and Pathological Science
Henry I. Miller, M.D.
Cellular Imaging and Analysis Roundtable
Choosing the Right Model
Emory University Named to NCI Chemical Biology Consortium
Simplifying Antibody Conjugation Processes
Nick Gee, Ph.D.
Demystifying Medicinal Chemistry Efforts
Steve Gardner
Using Metabolomics to Optimize Bioprocessing
Don Rose, Ph.D.
Antidotes for an Ailing Biotechnology Sector
Sumantha R. Sedor

August 1, 2009 (Vol. 29, No. 14)
Addressing Ligand Binding Assay Deficiencies
Kevin Brady
Infectious Diseases a Key MDx Market Driver
Kevin Leong
Novel Alzheimer’s Therapies Gaining Ground
Carol Potera
GEN Update on Promising Emerging Biotechnologies
Microarrays for Gene-Expression Studies
Elizabeth Lipp
PCR Technology Review: Standardization of qPCR and RT-qPCR
Stephen A. Bustin, Ph.D.
Jo Vandesompele, Ph.D.
Michael W. Pfaffl, Ph.D.
Italian Biotech Revamps Old-World Mindset
Alberto Onetti, Ph.D.
Charles S. Versaggi, Ph.D.
Bruce F. Mackler, Ph.D., J.D.
Overcoming Phase II Attrition Problem
Allan B. Haberman, Ph.D.
Making Bioprocess Scale-Up More Robust
Angelo DePalma, Ph.D.
Bringing Greater Efficiency to Antibody Manufacturing
Susan Aldridge, Ph.D.
Bioreactor and Fermentor Market Trends
Vicki Glaser
Perspective on PR: Building an Effective Communication Program
Tony Russo, Ph.D.
Innovative Drug Screening Methodologies
K. John Morrow Jr., Ph.D.
Utilizing Biomarkers to Their Full Extent
Nina Flanagan
Ninth Circuit Rules on IP and Antitrust Issues
Christine Garrett Devlin
William Diaz
Technological Advances Increase the Risk of Genetic Identity Theft
Alan McHughen, Ph.D.
Biosimilars and Follow-On Branded Biologics
Bruce F. Mackler, Ph.D., J.D.
Single-Use Noninvasive Sensing Technology
Jim Furey
High-Throughput Nanovolume qPCR
David Gelfand, Ph.D.
Kumar Kastury, Ph.D.
Streamlining In Silico Compound Profiling
François Petitet
Stabilization Method for Biological Samples
Mats Borén, Ph.D.
Increasing Production Process Efficiency
Merlind Muecke, Ph.D.
Susanne Leonhartsberger, Ph.D.
Biotechnology Investments Exhibit Resilience
Robert Dellenbach

July 1, 2009 (Vol. 29, No. 13)
Automating Magnetic Bead Multiplex Assays
Jason Greene
Stem Cell Possibilities Energize the Market
Harold Gross
Microsoft Strengthens Its Involvement in Life Sciences
Carol Potera
Building a Successful Biotech Incubator
Gail Dutton
Upgrading Cell-Based Viability Assays
K. John Morrow Jr., Ph.D.
Meeting Biomagnetic Separation Needs
Gail Dutton
Creating Therapies via the RNAi Route
Patricia F. Dimond, Ph.D.
High-End Mass Spec Systems Introduced
Vicki Glaser
Competition Mounting in Peptide Market
Vicki Glaser
European Overview: Firms Look for Niche in Peptide Synthesis
Sophia Fox
Getting Real with Downstream Processing
Angelo DePalma, Ph.D.
Applying Novel Biologic Production Methods
Susan Aldridge, Ph.D.
Getting the Most out of Quantitative PCR
Catherine Shaffer
Choosing a Clinical Trial Disclosure System
Satish Tadikonda
Navigating Pharmacogenomics Patenting
Y. Philip Zhang, Ph.D., J.D.
Therapy and Enhancement: Is There a Moral Difference?
Patrick Lin, Ph.D.
More from the Floor at ASMS: Boosting Analytical Capabilities
Vicki Glaser
Automating Physical Passage of Stem Cells
Kristi Hohenstein, Ph.D.
Gary Bright, Ph.D.
Anuradha Soundararajan
Expanding Disposable Depth-Filter Applications
Scott W. Anderson
Mike Collins
Manfred Muehl
Fluidics-Free Molecular Interactions Analysis
Krista Witte, Ph.D.
Significant Change Predicted for Bioindustry
Benjamin J. Conway

June 15, 2009 (Vol. 29, No. 12)
Solutions for DNA Copy-Number Analysis
Vanessa L. Ott, Ph.D.
The Rise of Short- and Rapid-Acting Opioids
Terence McManus, Ph.D.
Tackling Production Problems with Hydrogels
Carol Potera
Catching Up to Multiplexing Technology
Elizabeth Lipp
Protein Engineering Reaches New Frontiers
Nina Flanagan
Improving Biomarker Validation
Gail Dutton
Alternative Feedstocks Boost Ethanol Production
Vicki Glaser
Tech Transfer Key to CMO Cost Reductions
Susan Aldridge, Ph.D.
Nature and Nurture Benefit Cell Lines
Angelo DePalma, Ph.D.
Perspective: Boutique-Level Service in the CMO Sector
Roger Lias, Ph.D.
Banked-Specimen Retrospective Studies
Jeffrey Gibbs
Spotlight on the FDA
Bruce F. Mackler, Ph.D., J.D.
Screening Membrane-Associated Targets
Anthony L. Shrout , Ph.D.
Advancing Western Blots with Digital Imaging
Mike Collier, Ph.D.
Lisa Isailovic
Tamara R. Golden, Ph.D.
Real Time Multiplexed Protein Measurement
Wei Hu, Ph.D.
Jean-Francois Houle, Ph.D.
Paul Smith
2-D DIGE Improves Process Understanding
Åsa Hagner-McWhirter, Ph.D.
Maria Winkvist, Ph.D.
Lennart Björkesten, Ph.D.
Gunnar Malmquist, Ph.D.

June 1, 2009 (Vol. 29, No. 11)
High-Content Cytotoxicity Analysis
Paul Wylie, Ph.D.
Mike Janes
Molecular Cytogenetic Tools
Jonathan Witonsky
Ambit Has High Hopes for Kinase Screening Tool
Carol Potera
Long-Term Viability in a Down Market
Tamara Zemlo, Ph.D.
San Diego Pioneers Cleantech Solutions
Carol Potera
Novel Antibody Microarray Technology
Sophia Fox
Investigating and Focusing on Ion Channels as Drug Targets
Sue Pearson, Ph.D.
Epigenetics Fortifies Cancer Armamentarium
Gail Dutton
Delivery Approaches for RNAi-Based Drugs
James Netterwald, Ph.D.
Single-Cell Genomics Clarifies Big Picture
Richard A. Stein, M.D., Ph.D.
Overcoming Protein Production Hurdles
K. John Morrow Jr., Ph.D.
China Increases Healthcare Investment
Qing Xia
Daming Chen
Ramping Up Flu Vaccine Efforts
Gail Dutton
Patentability of Genetic Sequences Limited
William L. Warren
Lei Fang, Ph.D., M.D.
Science and Technology Are Essential to Economic Recovery
Henry I. Miller, M.D.
Purdue Scientist Gets Moving on Vaccine against H1N1
Controlling Nutrient Release in Cell Cultivation
Antje Neubauer, Ph.D.
Russell Golson
Kaisa Ukkonen
Mirja Krause
Hanna Tegel
Jenny Ottosson
Marianne Wittrup Larsen
Karl Hult
Peter Neubauer
Antti Vasala
Using Mass Spectrometry for Tissue Imaging
Maria C. Prieto Conaway
Shousong Cao
Farukh Durrani
Youcef Rustum
Ping Wang
Khin Marlar
Latif Kazim
Managing Data from Screening Effectively
Andy Vines
Identifying New Gene-Expression Patterns
Nicola C. Day, Ph.D.
Sandra Williams, Ph.D.
Improving Protein Yields in Mammalian Cells
Steven Williams, Ph.D.
Rocky Cranenburgh, Ph.D.
Defending the Actions of Activist Shareholders
David Sable, M.D.

May 15, 2009 (Vol. 29, No. 10)
Managing Protein Biomarker Assay Workflow
Ruth A. VanBogelen, Ph.D.
Richard C. Jones, Ph.D.
M. Walid Qoronfleh, Ph.D.
Are In Vitro Diagnostics Recession-Proof?
Bruce Carlson
Forging Isobutanol with Modified Microbes
Carol Potera
Tough Times Ratchet Up Need for Partners
Susan Aldridge, Ph.D.
Natural Resources Buoy Chilean Biotech
Robert Yuan, Ph.D.
New MS Tools Advance Biomolecular Studies
K. John Morrow Jr., Ph.D.
CGH Sheds Its Light on Disease Etiology
Mary Addonizio
“Greening” of Labs and Manufacturing
Angelo DePalma, Ph.D.
Delivery Firms Focus on Efficiency & Efficacy
Patricia F. Dimond, Ph.D.
Nasal Administration Methods Stake Out Niche
Alan Smith, Ph.D.
Decoding Cell Communication
Kathy Liszewski
Strategies for Removing Viruses from Cell Lines
Gail Dutton
GEN's Spotlight on the FDA
Bruce F. Mackler, Ph.D., J.D.
Obtaining Reliable PCR from Seed DNA
Les Hoffman, Ph.D.
Shannon Krueger
High-Speed Sample Volume Measurement
Chris Walsh
New Tool Recombineers the DNA of E. coli
Tim Zeppenfeld, Ph.D.

May 1, 2009 (Vol. 29, No. 9)
Lab Automation Protocols and Virtual Workcells
Alan H. Katz, Ph.D.
Securing a Slice of NIH Stimulus Funding
Christianne Bird
PharmAthene Secures Biodefense Position
Carol Potera
Emerging Biotechnology Clusters
Gail Dutton
ADMET Increasingly Integral to Discovery
Elizabeth Lipp
Practical Applications of Systems Biology
Richard A. Stein, M.D., Ph.D.
Ramping Up Effort for Improving Kinase Assays
Nina Flanagan
Novel Ways of Looking at Old Problems
K. John Morrow Jr., Ph.D.
Oligo Market Benefits from RNAi Focus
Vicki Glaser
HPLC Thrives on Speed and Efficiency
Angelo DePalma, Ph.D.
Recent Decisions Curtail Personalized Medicine
Brenda Herschbach Jarrell, Ph.D., J.D.
Fangli Chen, Ph.D., J.D.
Rebuttal: Gov’t Should Not Open Coffers to VC Firms
William Bains
Arguments against President Obama’s Stem Cell Policies
Gilbert Meilaender, Ph.D.
Automated Capillary Isoelectric Focusing
Sugars Are Sweet
Small and Smaller
Identifying Cardiotoxic Compounds
Blake D. Anson, Ph.D.
Junyi Ma, M.D., Ph.D.
Jia-Qiang He, Ph.D.
Standardization in Biomarker Discovery
James R. Dasch, Ph.D.
Keith R. Solomon, Ph.D.
Marina Hincapie, Ph.D.
David Sarracino, Ph.D.
Improving LC/MS Analysis of Oligonucleotides
Michael McGinley
Gregory Scott
LIMS Streamlines Translational Science
Trish Meek
VC Lock-Down Mode Paralyzes Bioindustry
Rod Raynovich

April 15, 2009 (Vol. 29, No. 8)
Breaking HTS Cell-Based Assay Bottlenecks
James P. Brady Jr., Ph.D.
Karen A. Donato, Ph.D.
Synthetic Bio's Promise Places It on Fast Track
Mark Bunger
Firm Aims to Regulate RNA in Rare Diseases
Ilene Schneider
Fine-Tuning Sample Preparation Techniques
Elizabeth Lipp
Budgets Shifting in Biopharma Manufacturing
Eric S. Langer
POC Testing Predicted to Transform Healthcare
Ian George, Ph.D.
Capitalizing on Fragment-Based Discovery
Kathy Liszewski
Focused Assays Lead to More Potent Drugs
Nina Flanagan
Novel Systems Zero In on the $100 Genome
K. John Morrow Jr., Ph.D.
Removing Impediments in Downstream Processing
Angelo DePalma, Ph.D.
Partnerships Strengthen Finland Biotech
Susan Aldridge, Ph.D.
Spotlight on the FDA
Bruce F. Mackler, Ph.D., J.D.
Transforming Bioprocessing as We Know It
Detection Method for Conformational Change
Joshua Salafsky, Ph.D.
Easing Challenges in QbD Implementation
Andreas Schneider
Accelerating Preclinical Imaging Workflow
Santosh S. Arcot, Ph.D.

April 1, 2009 (Vol. 29, No. 7)
High-Content Methods to Assess Toxicity
Mark A. Collins, Ph.D.
Cancer Molecular Diagnostics Take the Stage
Sudeep Basu, Ph.D
Firm on Quest to Improve Biomanufacturing
Carol Potera
Unveiling Cellular Bioenergetics’ Secrets
Richard A. Stein, M.D., Ph.D.
Digital Gene-Expression Profiling
Vicki Glaser
Traditional Strengths Solidify Chilean Biotech Industry
Gail Dutton
Ongoing Pursuit of Sustainable Operations
Angelo DePalma, Ph.D.
MDx Will Drive Personalized Medicine
Vicki Glaser
Unearthing More Effective Therapies for Anthrax
Matthew Meldorf, M.D.
Getting a Handle on Metabolic Disorders
David Daniels, Ph.D.
New qPCR Workflows Accelerate Discovery
Lloyd Dunlap
Gov’t Actions Buoy European Start-Ups
Susan Aldridge, Ph.D.
Enforceable Diagnostic Method Patents
Edmund R. Pitcher
Brian A. Fairchild, Ph.D.
Deficiencies in Forensic Science Training Must Be Met Head-On
Richard E. Bisbing
Initiatives Advancing Chilean Life Sciences
Robert Yuan, Ph.D.
New and Old Technologies Boost Advances
Sophia Fox
Schizophrenia Research with Real Time PCR
Strategies for Measuring Viable Biomass
John Carvell
Measurement of Global DNA Methylation
Deborah L. Vassar
Ernest J. Mueller, Ph.D.
Savita Bagga, Ph.D.
Staying Ahead of Activist Stockholders
Joseph E. Gilligan
Brian C. O'Fahey

March 15, 2009 (Vol. 29, No. 6)
Working with Cryopreserved Hepatocytes
Ji Young Lee, Ph.D.
Timothy A. Moeller
Combating Hospital-Acquired Infections
Bruce Carlson
Honing In On Fatty Liver Disease Treatment
Joe Levit
Madoff Matters, But Larger Issues Loom
Gail Dutton
Making Improvements to Standard of Care for HCV
Elizabeth Lipp
Advances in Label-Free Assay Screening
Patricia F. Dimond, Ph.D.
Protein Microarrays See Broader Utilization
K. John Morrow Jr., Ph.D.
Fledgling Firms Needed to Fill U.K. Void
Susan Aldridge, Ph.D.
U.S. Biofuels Market Off and Running
Ellyn Kerr
miRNA Profiling Opens Doors for New Drugs
Nina Flanagan
Maximizing Value in Outsourcing Services
Kathy Liszewski
Economic Crisis Provides a Potential Boost to IP Portfolio
Narinder S. Banait, Ph.D., J.D.
Determining Small Molecule Binding Kinetic Constants
GEN BIO Theater Presentations
microRNA Expression Profiling of Carcinomas of Unknown Origin
Novel OncoMouse Model
China Gains in Innovative R&D
Mycoplasma Contamination in Culture Media
Maik W. Jornitz
Theodore H. Meltzer , Ph.D.
Dissecting Protein-Protein Interactions
Eric J. Sundberg
Desorption Electrospray Ionization
Justin M. Wiseman
Peter T. Kissinger

March 1, 2009 (Vol. 29, No. 5)
Drug Absorption on Membrane Arrays
Voula Kodoyianni, Ph.D.
Christine Angevine, Ph.D.
Pharma’s Ongoing Quest for R&D Innovation
Carolyn Buck-Luce
Mark B. Hassenplug
Agilent Expands Its Capabilities in Robotics
Carol Potera
Researchers Map Neanderthal Genome
Revitalizing Surface Plasmon Resonance
Diana Gitig
TechNote: High-Throughput Kinase Selectivity Profiling
Mazen Karaman, Ph.D.
Dan Jones
Paul Gallant
Review: LabAuto Product Introductions
Ilene Schneider
Shining a Different Light on Genetic Diversity
Richard A. Stein, M.D., Ph.D.
Quality Makes a Difference in RNA Prep
K. John Morrow Jr., Ph.D.
DNA Vaccines Inch Toward Human Use
Gail Dutton
Grappling With Biologic Manufacturing Concerns
K. John Morrow Jr., Ph.D.
CMOs Hold Their Ground in Troubled Times
Angelo DePalma, Ph.D.
Quest for Fully Disposable Process Stream
Vicki Glaser
Business Continuity & Recovery Strategies
Merrilee Galloway
Mark Dyment
Personalized Medicine Grows in Fits and Starts
Lloyd Dunlap
Clinical Proteomics Heads Into Real World
N. Leigh Anderson, Ph.D.
Making the Most of Pre-IDE Meetings
Jeffrey Gibbs
China Stays Committed to Biodevelopment
Zhu Shen, Ph.D.
Standard Setting Increasingly Under Siege
Steven B. Pokotilow
Amy E. Wilson, Ph.D.
Benjamin P. Liu
Stem Cell Funding Roadblock
Bernard Siegel, J.D.
Measuring Multiplexed Signal Transduction
Shannon Henery
Thaddeus George
Low Metabolic Burden Plasmid Production
Aaron E. Carnes
James A. Williams
Impact of Risk Mitigation on Deal Market
Mark A. Metcalf

February 15, 2009 (Vol. 29, No. 4)
Second Messengers’ Accumulation Assays
Jean-Luc Tardieu, Ph.D.
Sky Could Be the Limit for DNA Testing
Bruce Carlson
Stratatech Builds on Cell Line Discovery
Carol Potera
PerkinElmer Retools Its Strategic Mission
Carol Potera
Case Study: Overcoming Antimicrobial Resistance
Ramin Najafi, Ph.D.
Does Offshoring Put Patents in Jeopardy?
Jeremy Minshull, Ph.D.
Low-Volume Liquid Handling Gaining Favor
Gail Dutton
Boosting Potential LC/MS Operations
Nina Flanagan
New Antibody Engineering Technologies
K. John Morrow Jr., Ph.D.
S. Korean Gov’t Nudges Biotech Along
Robert Yuan, Ph.D.
Pathway Knowledge Can Benefit Cancer Therapeutics
David Daniels, Ph.D.
Honing In on Targeted Resequencing
Kathy Liszewski
Overreacting to Perceived Risks
Henry I. Miller, M.D.
Recent Advances in NextGen Sequencing
Executive Interview: Reinhard Vogt, Sartorius Stedim Biotech
Modeling Ensemble Powers Systems Biology
Colin Hill
Peristaltic Aseptic Filling Instrumentation
Peter Lambert
Chuck Treutel
Tools That Facilitate Metabolite Identification
Yingying Huang, Ph.D.

February 1, 2009 (Vol. 29, No. 3)
Simplification of Kinase Binding Assays
Steven M. Riddle
miRNA Solidifies Role in Disease Research
Christianne Bird
CytImmune Banks on Gold Nanoparticles
Ilene Schneider
GEN’s Annual Wall Street Roundup
European Bioindustry Upbeat in the Long Term
Susan Aldridge, Ph.D.
Epigenomics Rises as Key Research Tool
Richard A. Stein, M.D., Ph.D.
Improving Delivery of RNAi Drugs
Nina Flanagan
Israeli Initiatives Seek to Sidestep Funding Crisis
Vicki Glaser
Uncovering Applications for DNA Forensics
Elizabeth Lipp
Alternatives to Mammalian Expression
K. John Morrow Jr., Ph.D.
Targeting Post-Translational Modifications
Angelo DePalma, Ph.D.
Raising Molecular Imaging to Higher Level
Gail Dutton
Strategies to Overcome Blood-Brain Barrier
Allan B. Haberman, Ph.D.
Chinese Outsourcing Nears Full Service
Jim J. Zhang, Ph.D.
Court Ruling May Impact Life Science Patents
Jeffrey D. Hsi
Elizabeth N. Spar
Venture Capital Firms Need Access to Government Coffers
J. Leslie Glick, Ph.D.
GEN’s MicroArray Challenge Solved
John Sterling
Promega's Protein Purification Project
Novozymes Exploits a Venerable Bioproduction Tool for Contract Manufacturing Operations
Visualizing Signal Transduction Pathways
Simon Fredriksson
GEN's Interview with Dr. Francisco J. Ayala
Accelerating Protease Drug Development
NIcholas J. Ede, Ph.D.
Three-Dimensional Cultivation of Cells
Hans Hoffmeister, Ph.D.

January 15, 2009 (Vol. 29, No. 2)
Tools for Studying Membrane Protein Targets
Soma S.R. Banik, Ph.D.
Christopher J. Laing, Ph.D.
Benjamin J. Doranz, Ph.D.
Capitalizing on Novel Expression Systems
Eric S. Langer
GenomeQuest Aims to Streamline Genomics
Carol Potera
Japanese BioAlliance Strategies Evolving
Tom Burger
James E. Foley, Ph.D.
Automation Drives Laboratory Economics
Catherine Shaffer
Identifying Best Practices for Advanced Therapies
Susan Aldridge, Ph.D.
Exploiting the Value of Cancer Biomarkers
Diana Gitig
Enhancing PCR for Diagnostic Applications
Lloyd Dunlap
Microfluidics Makes Strides to Fulfill Promise
Kathy Liszewski
Does Fusion Therapy Have a Role in Cancer?
John M. Pawelek, Ph.D.
Culture Media Underly Productivity Gains
Angelo DePalma, Ph.D.
Keeping the “Person” in Mind in Personalized Medicine
Peter Traber, M.D.
BD Biosciences Expands Capabilities in Cell Culture Media
Shut-off Switch for Cellulose Production Found
Finessing PI3 Kinase Assay Development
Kevin Entwistle
Minimizing Challenges in Biological Modeling
Kristen Zanella
Researchers Tackle Tumors One Cell at a Time
Frank Feist
Optimization of Binding Interaction Studies
Laura Moriarty, Ph.D.
Online Monitoring of In-Process Samples
Tanya Jenkins

January 1, 2009 (Vol. 29, No. 1)
High-Throughput Automation of DNA Extraction
David Saul, Ph.D.
Nick Price, Ph.D.
Fast Growth Foreseen for Protein Therapeutics
Andrea Hiller
Sequella Takes On Pernicious Enemies
Ilene Schneider
High-Content Screening Rapidly Evolving
David Daniels, Ph.D.
Linking Disease to Gene Variations
Vicki Glaser
Cautious Optimism Prevails for Chinese Biotechnology
Gail Dutton
Exploring the Human Proteome in Depth
Elizabeth Lipp
Utilization of DNA Microarrays Increasing
K. John Morrow Jr., Ph.D.
Peptide Capacity Holding Steady For Now
Vicki Glaser
Stem Cells Continue March Toward Clinic
Nina Flanagan
Korea Lays Groundwork for Future Success
Robert Yuan, Ph.D.
Update on Patent Law Revisions in China
Lisa A. Haile, J.D., Ph.D.
Will New Appointment Wax Healthcare Reform?
Rod Raynovich
Beijing Institute of Genomics Expands Applications for Life Technologies’ SOLiD System
Technology Showcase for New Screening Software
Celebrating Charles Darwin in 2009
John Sterling
Impact of Ultrafiltration of Hydrolysates
Tobi Limke, Ph.D.
Tritiated Opiate Receptor Radioligands
Crist N. Filer, Ph.D.
Assessing a Company’s Financial Health
David Sable, M.D.

December 1, 2008 (Vol. 28, No. 21)
Utilization of an Automated Triplex Assay
Andrew Niles
Simon T.M. Allard, Ph.D.
Jason Greene
Sarah Shultz
Moving Flow Cytometry Beyond Core Facilities
Madhu Sharma, Ph.D.
Tripos International Returns to Its Roots
Carol Potera
Q&A: Life Technologies Formed from AB/Invitrogen
David Daniels, Ph.D.
Doubts Stymie Implementation of RFID
Angelo DePalma, Ph.D.
Zeroing in on PI3K Pathway
Nina Flanagan
Spain Invests in Quest for Big Biotech Payoff
Sue Pearson, Ph.D.
Flow Cytometry Applications Proliferate
Sophia Fox
Update on Emerging Biobanking Practices
Catherine Shaffer
Improving Delivery thru Nanotechnology
Gail Dutton
Status of Biosimilars in U.S. Could Soon Change
Veronica Mullally
Tips on How to Properly Construe Patent Claims
John P. Iwanicki
Vilification of Bovine Growth Hormone Udderly Unwarranted
Henry I. Miller, M.D.
New FC Systems Measure More Variables Over Shorter Time Periods
K. John Morrow Jr., Ph.D.
Methylation-Sensitive Hi-Res Melting Analysis
Cameron N. Gundry
Mikeal Wall
Jason T. McKinney
Colleen Hough, Ph.D.
Lindsey Cutler
John D. Phillips, Ph.D.
Margaret K. Yu, M.D.
David H-F Teng, Ph.D.
Optimizing Mammalian Cell Culture Performance
Sally Grosvenor
Taking Old & New Molecules Down Novel Paths
Stephen R. Byrn, Ph.D.
Sourcing Well-Characterized Biospecimens
Samir Alhasan, Ph.D.
Shannon Richey
Apurvi Desai
Biotech’s Umbilical Cord Has Been Severed
Peter Winter

November 15, 2008 (Vol. 28, No. 20)
Use of a Nano-Structured Proteomic Biochip
Anna A. Fisher, Ph.D.
James C. Nelson, Ph.D.
David Ure
GPCR Market Exhibits Rapid Diversification
Ken Rubenstein, Ph.D.
Aiming to Accelerate Discovery Process
Carol Potera
Methodology Garners Researchers’ Interest
Carol Potera
New Zealand Biotech Poised for Growth
Janet Mason
Achieving Success in Tox Studies
Gail Dutton
Synthetic Biology Finds a Niche in Fuel Alternatives
Elizabeth Lipp
Understanding the Biology of RNAi
Lloyd Dunlap
Single-Use Filtration Hits the Mainstream
Angelo DePalma, Ph.D.
Adroit Crafting of “Intended Use” Critical
Jeffrey Gibbs
Outsourcing Medicinal Chemistry Activities
Vicki Glaser
Industry Briefing: Adapting to a Transformed Economic World
Susan Aldridge, Ph.D.
Amylin Builds on the Success of Byetta
Querida Anderson
New Treatment Strategies for Inflammation Gain Ground
Yuval Cohen
Structure of Critical GPCR Determined
Companies Collaborate to Provide Integrated Solution to Preclinical Laboratory Workflow
LIMS Addresses Major Biobanking Challenges
Doug Holbrook
Off-Gas Analysis for Real-Time Process Control
Karin Koller
Chromatographic Column Characterization
Michael McBrien

November 1, 2008 (Vol. 28, No. 19)
Automating Cell Culture Operations in R&D
Lara Marchetti, Ph.D.
Photonics Poised to Cross Over into Biotech
Andrea Hiller
Firm Invests in New HIV Vaccine Strategy
Carol Potera
Removing Antigen Discovery Guesswork
Carol Potera
Waging a Multipronged Alzheimer’s War
Vicki Glaser
MS Sample Prep–Challenges and Pitfalls
K. John Morrow Jr., Ph.D.
Critical Issues When Selecting a CMO
Eric S. Langer
Accelerating Research into Clinical Setting
Winston Patrick Kuo, D.D.S., D.M.Sc.
Robert J. Distel, Ph.D.
Identifying Biochemical Threats Earlier
Gail Dutton
Latin American Biotech Steadily Emerges
Bruce F. Mackler, Ph.D., J.D.
qPCR Methods Expand Rapidly
David Daniels, Ph.D.
Vaccine Development Aided by New Techniques
Angelo DePalma, Ph.D.
Is Safe Harbor Closed to Research Tools?
William L. Warren
Donna Best
Quo Vadis Biofuels Projects?
Michael S. Koeris, Ph.D. Student
Biofuel Standards
DNA Vaccines Meeting
New Multiplex Approach for Rapid Diagnostics
Production of High Secretion Cell Lines
Imran Clark, Ph.D.
HaYong Lim
Kristi Hohenstein, Ph.D.
Gary Bright, Ph.D.
mRNA Analysis with Next-Gen Sequencing
Gary P. Schroth, Ph.D.
Unfulfilled Promise of Predictive Toxicology
Joseph Zock
Rebecca J. Palmer
Using Microdosing to Enhance Development
Graham Johnson, Ph.D.
Preparing for a Shrinking Economic World
Daniel Ruppar

October 15, 2008 (Vol. 28, No. 18)
High-Throughput Live-Cell Imaging Assays
Carolyn Conant, Ph.D.
Animal Therapeutics and Diagnostics
Melissa Elder
Taking DNA-Guided Medicine to the Clinic
Engineering Droplets for DNA Sequencing
Carol Potera
Cashing in Your Chips to Advance Discovery
K. John Morrow Jr., Ph.D.
Benefits of Integrating IT and Team Building
David Dunn
Strengthening Mammalian Cell Culture
Angelo DePalma, Ph.D.
Exploiting Advances in Image Analysis
Richard A. Stein, M.D., Ph.D.
Regenerative Therapies Gain Momentum
Elizabeth Lipp
Deciphering Biological Networks
Kathy Liszewski
Fine-Tuning the Design of GPCR Therapeutics
Carol Potera
Patent Update: Redefining Written Descriptions for Patents
William L. Warren
Mark Westhafer, Ph.D.
VC Funding for Biotech Firms
J. Leslie Glick, Ph.D.
What's Driving Dealmaking in Biopharma?
Advanced Imaging Applications
Richard A. Stein, M.D., Ph.D.
Screening Test for Traumatic Brain Injury
Galina Bernstein, Ph.D.
Wei Hu, Ph.D.
Validation of Protein Quantification Assays
Katja Aschermann, Ph.D.
Martin Blüggel
Andreas Wattenberg, Ph.D.
Taking Aim at Gene-Regulation Research
Constanze Kindler, Ph.D.
Expediting Purification of Cellular Proteins
Manfred Koegl, Ph.D.

October 1, 2008 (Vol. 28, No. 17)
Quantifying Cell Migration and Invasion
Keren I. Hulkower, Ph.D.
Maria Perr
Lipid-Modifying Therapies Face Flat Sales
Sreten Bogdanovic, Ph.D.
ZyGEM Builds DNA Extraction Kit Portfolio
Carol Potera
Bacteriophage-Based Antibiotic Therapy
Carol Potera
Opinion: Reining In New Therapeutic Hype Is Critical
Michael Feehan, Ph.D.
Rich Durante, Ph.D.
Protein Quantification Pinpoints Targets
K. John Morrow Jr., Ph.D.
Predicting Adverse Drug Reactions
Susan Aldridge, Ph.D.
FDA Pushes PAT and Companies Shove Back
Eric S. Langer
Cell Imaging Makes Strides in Drug R&D
Nina Flanagan
Biomarker Assay Use Increases
Lloyd Dunlap
CMOs See Robust Growth
William Downey
Redefining Obviousness After KSR Decision
George C. Yu
John Kappos
Substantive Progress Is Being Made in Breast Cancer Survival
Judith-Anne Chapman, Ph.D.
Novel Cell Culture Optimization Strategy
Cindy Neely, Ph.D.
Enzyme Immobilization on Polymeric Resins
Jon Fisher
Tools for Enhancing Vitamin D Therapeutics
Christian Helvig, Ph.D.
Martin Petkovich, Ph.D.
Targeted Genome Editing via ZFN Methodology
Greg Davis, Ph.D.
Trevor Collingwood, Ph.D.
Phil Simmons
Molecular Diagnostics Take Center Stage
Rod Raynovich

September 15, 2008 (Vol. 28, No. 16)
Assay Tools for Nuclear Hormone Receptor Studies
Mahesh Mathrubutham, Ph.D.
Patricia Whaley, Ph.D.
Tom Wehrman, Ph.D.
Keith Olson, Ph.D.
Pitfalls Undermine Promise of Theranostics
Kenneth P. Krul, Ph.D.
Chemical Firm Enters Biopharma CMO Sector
Susan Aldridge, Ph.D.
Firm’s Pipeline Targeted at HPV and Cancer
Carol Potera
Biotech Crops Directly Tied to Higher Yields
Terry Wanzek
Capitalizing on the RNAi Space Expansion
Elizabeth Lipp
Metabolite Profiling Speeds Diagnostic Efforts
K. John Morrow Jr., Ph.D.
Disposable Use Proliferates in Production
Angelo DePalma, Ph.D.
Users Are Sold on Single-Use Systems
Eric S. Langer
Refining Protein Drug Formulation
David Daniels, Ph.D.
FDA Backs PAT to Help Solve Manufacturing Woes
Lloyd Dunlap
RNAi’s Potential Is Spurring Alnylam’s Value
Querida Anderson
Thwarting Domestic Terrorism
Henry I. Miller, M.D.
Using Metabolomics in Biomarker Discovery
Walter E. Gall, Ph.D.
mAb Capture from Unclarified Feedstock
Allan Lihme
Rob Noel, Ph.D.
Standard Materials for Clinical Proteomics
Peter Schulz-Knappe
Improving High-Res Mass Spec Formula ID
Don Kuehl

September 1, 2008 (Vol. 28, No. 15)
Proficient Use of Sandwich Antibody Arrays
Roberto Campos-Gonzalez, Ph.D.
Kathy Brumbaugh, Ph.D.
Dave Finkel
Greta Wegner, Ph.D.
Jackie Ernst
Nucleic Acid Purification Market Expands
Christianne Bird
Platform Simulates Human Capillaries
Carol Potera
Delivery of Time-Lapsed Live-Cell Imaging
Carol Potera
Peptide Drugs Becoming More Prevalent
Vicki Glaser
In-Line Analytics Improve Manufacturing
Gail Dutton
Cell Counting and Process Monitoring
Susan Aldridge, Ph.D.
USPTO Backlog Impacts Biopharma Industry
Anthony Tridico
Jim Kastenmayer
Ali Kargbo
Makeover Mandated for U.K. Life Science Sector
Sophia Fox
Marketing Analysis: What Is the Future of DTC Drug Advertising?
Wendy Macias, Ph.D.
Roundtable Discussion: Future High-Throughput Screening Directions
Next-Generation Sequencing Update
Richard A. Stein, M.D., Ph.D.
Improving R&D as well as Disease Prognosis
Nina Flanagan
Creative Applications of qPCR Proliferate
Catherine Shaffer
FDA Seeks to Establish Branch Office in China
Gail Dutton
Bio Directive Fails to Unify European Law
Matthew Royle
Gareth Morgan
Simon Cohen
Undermining Scientific Credibility
Alan McHughen, Ph.D.
Sample Quantitation with Microvolume Tools
Joel Hansen, Ph.D.
Philippe Desjardins
Finding Proteins in Cell-Conditioned Media
Judith Nagy, Ph.D.
Yunyi Kang
Anthony Cass
Athanasios Mantalaris
Automated Purification for Genetic Trait Maps
Jethro Holter
Tone Yrvum
Spiral Countercurrent Chromatography
Martha Knight, Ph.D.
Digital Pathology in Preclinical Research Arena
Steve Potts, Ph.D.
VC Funding for Biotech Companies Withering
Robert Dellenbach

August 1, 2008 (Vol. 28, No. 14)
Achieving Precision Analysis with ELSD
Simon Robinson
Pharma Outsourcing on Upward Trajectory
Bruce Carlson
SRI Boasts Abilities in Early- and Late-Stage R&D
Carol Potera
Company Touts Its Novel Sequencing Technique
Is the U.K. Biotech Industry on the Skids?
Sue Pearson, Ph.D.
Antibody Processing Platforms Evolve
K. John Morrow Jr., Ph.D.
Flexibility Crucial in Bioreactor Systems
Elizabeth Lipp
Regulatory Pathways for Molecular Dx
Jeffrey Gibbs, Esq.
A Sensible Approach to Interpreting Research
Elizabeth M. Whelan, M.D.
Strengthening the Biotechnician Workforce
John Sterling
GEN Review BIO 2008: Tips for Doing Business in China and India
Gail Dutton
GEN Review BIO 2008: Grappling with the Regulation of Biosimilars
K. John Morrow Jr., Ph.D.
GEN Review BIO 2008: News from the Floor of BIO's Annual Meeting
Roundtable Discussion: High-Throughput Screening Challenges
Novel Approaches to Lead Optimization
Elizabeth Lipp
Protein Analysis Technologies Overview
Vicki Glaser
Applicability of Biomarkers Is Far-Reaching
David Daniels, Ph.D.
Ancillary Analysis Tools for Microarrays
Sophia Fox
Novel MS Systems Expedite Workflow
Gail Dutton
Platform Technologies Ease Scale-Up Pain
Angelo DePalma, Ph.D.
Batch Failure Rates in Biomanufacturing
Eric S. Langer
Graduate Programs that Prepare for NonResearch Careers
Molly B. Schmid
Advancing Gene Expression Studies
Lloyd Dunlap
Monoliths Emerge as Key Purification Methodology
Pete Gagnon
Enforceability of Patent Licenses Under Fire
Courtenay C. Brinckerhoff
Successful Genetic Tests Are Predicated on Clinical Utility
Diane Allingham-Hawkins, Ph.D.
Small-Scale Parallelized Biochromatography
Lothar Britsch, Ph.D.
Tim Schroeder
Jurgen Friedle, Ph.D.
Making Antibiotics Obsolete in Fermentation
Daniel Stieber, Ph.D.
Philippe Gabant, Ph.D.
Cedric Szpirer, Ph.D.
Fast PCR with Long and Difficult Amplicons
Haiyang Grunenwald, Ph.D.
Measurement of Proteins in FFPE Tissue
Casey Eitner
David B. Krizman, Ph.D.

July 1, 2008 (Vol. 28, No. 13)
Bioluminescent Assays for Potency Assessment
Sarah Schultz
Andrew Niles
Jey Cheng, Ph.D.
Simon T.M. Allard, Ph.D.
Adoption of Molecular Diagnostics Slowing
Kevin Leong
Firm's Bailiwick Based on Protein-Protein Expertise
Carol Potera
Compound Discovery Tools Still Evolving
Elizabeth Lipp
Can In Silico Modeling Speed Development?
K. John Morrow Jr., Ph.D.
Biomagnetic Separations See Increased Use
Gail Dutton
Reducing Downstream Purification Costs
Angelo DePalma, Ph.D.
Peptide Boom Puts Pressure on Synthesis
Susan Aldridge, Ph.D.
Staying Ahead of Upstream Developments
Susan Aldridge, Ph.D.
Quantifying Downstream Capacity Crunch
Eric S. Langer
Primer on Regulation of Diagnostic Assays
Jeffrey Gibbs, Esq.
Conquering RNAi Delivery Challenges
Kathy Liszewski
Sample Prep Initiatives Will Advance Proteomics
Nina Flanagan
Preventing Discord in Research Collaborations
Stewart Lyman, Ph.D.
Trends in Synthesis and Manufacturing
Diana Gitig
Recasting the Federal Debate on Stem Cells
Joseph R. Sollee
GINA Provides Bioindustry Boost
Sharon Terry
Joann Boughman, Ph.D.
Assay: Avoiding Interference in Immunoassays
Tobias Polifke, Ph.D.
Peter Rauch, Ph.D.
Choosing a Normalization Strategy for RT-PCR
Anders Bergkvist
Amin Forootan
Neven Zoric
Linda Strombom
Robert Sjoback
Mikael Kubista
Focusing on Task of Reinventing Peptide Drugs
Warren P. Levy, Ph.D.
Strategies for Streamlining Bioproduction
Jill Staggert
The Paradox of Biotechnology Value Investing
David Sable, M.D.

June 15, 2008 (Vol. 28, No. 12)
Planning for Success in Biomarker Discovery
Enrique A. Dalmasso, Ph.D.
SNPs—A Shortcut to Personalized Medicine
Bruce Carlson
Almac Offers a Range of Integrated Services
Susan Aldridge, Ph.D.
Overcoming Complications in Multiplexing
Catherine Shaffer
Managing Asthma and COPD Treatments
Sue Pearson, Ph.D.
TechUpdate: Are Lentiviral Vectors on Cusp of Breakout?
Tim Ravenscroft
Turning Research into Viable Cancer Drugs
John F. Wong, Ph.D.
Tackling Drug-Interaction Issues Early On
Elizabeth Lipp
Finding Balance in Cell-Line Development
Angelo DePalma, Ph.D.
Methods for Maximizing Antibody Yields
K. John Morrow Jr., Ph.D.
Optimizing Utilization of Biomarkers
Kathy Liszewski
Flexibility Is the Name of the Game for CROs
Lloyd Dunlap
Osiris Trumpets Its Adult Stem Cell Product
Querida Anderson
No Member of Congress Left Behind
Henry I. Miller, M.D.
Counting Chromosome Copy Numbers Efficiently
Roland Kirchner, Ph.D.
Claudia Holzhauer
Frank Feist
Wolfgang Mann, Ph.D.
Marianna Alunni-Fabbroni, Ph.D.
Improving Synthetic Oligo Purification Process
Gregory Scott
Cathy Cordova
Michael McGinley

June 1, 2008 (Vol. 28, No. 11)
Cell Signaling Analysis Using Multiplex Assays
Scott Hayes, Ph.D.
Robyn M. Perrin, Ph.D.
Adults Now Drive Growth of Vaccine Market
Bruce Carlson
Novel Treatment Approach Leverages Epigenetics
Carol Potera
RNAi Researchers Galvanized by Advances
Elizabeth Lipp
Interrupting Protein-Protein Interactions
Diana Gitig
PAT Initiative Helps Move HPLC Forward
Angelo DePalma, Ph.D.
Norway's Oncology Efforts Are Coalescing
Susan Aldridge, Ph.D.
BioInsights: Biotech Industry Success Powered by Innovation
James C. Greenwood
Superbugs vs. Superdrugs: Race Goes On
Sue Pearson, Ph.D.
Ion Channels Play Key Role in R&D
David Daniels, Ph.D.
Digging for Insights through High-Content Data Mining
Gail Dutton
Off-Label Promotion Under Scrutiny by DOJ
Peter S. Spivack
Recreational Ancestry–Caveat Emptor?
Jonathan Marks, Ph.D.
Dispersive Raman Spectroscopy Utilization
Nesredin A. Mussa, Ph.D.
Benjamin P. Locwin
Honing In on Chemoresistance Pathways
Michael D. Becker
Observing Stem Cell Growth and Viability
Jennifer L. Peters, Ph.D.
William E. Jastromb
Inducement of Gene Expression or Silencing
Sanjay Vasu, Ph.D.
Jian-Ping Yang, Ph.D.
Adam N. Harris, Ph.D.
Wieslaw Kudlicki, Ph.D.
Tips for Emerging Firms on Obtaining Funding
Barbara Schilberg

May 15, 2008 (Vol. 28, No. 10)
Strategy to Improve Quantitative Telomere FISH
Rajiv Raja, Ph.D.
Zuguo Li, Ph.D.
Yun-Ling Zheng, Ph.D.
Demand for Novel Delivery Systems Rising
Bill Martineau
Company Seeks to Shake Up Protein Analysis
Sophia Fox
Symbiotic Firms Zero In on Enzymatic Tools
Carol Potera
Optimizing the Profiling of Protein Kinases
Patricia F. Dimond, Ph.D.
ELNs Ready for Large-Scale Deployment
Gail Dutton
Quest for Cancer Therapeutics Redirected
Irena Melnikova, Ph.D.
Applying aCGH to Molecular Diagnostics
Kathy Liszewski
Mass Spec Solidifies Discovery Role
Nina Flanagan
Filling Oligo Production Void
Vicki Glaser
Mannkind Persists with Inhaled Insulin
Querida Anderson
Genetic Science Confounds Students
Kenna Shaw, Ph.D.
Katie Van Horne
Joann A. Boughman, Ph.D.
Politically Speaking: Candidates Opine on Biotech & Health Issues
Obstacles to Presterilized Single-Use Filling
Jeff Jackson
Applications of New Synthesis Technologies in Drug Discovery and Development
William J. Blake, Ph.D.
Andy Rakestraw, Ph.D.
Patti M. Aha

May 1, 2008 (Vol. 28, No. 9)
Site-Specific Phosphorylation Profiling
Tim Nadler, Ph.D.
Ed Machuga
“Active” Products Drive Wound-Care Market
Toby Zaleski, Ph.D.
Targeting Diabetes-Related Heart Disease
Carol Potera
Search Continues for Injection Alternatives
Susan Aldridge, Ph.D.
Capitalizing on Abundant Opportunities in Wales
Susan Aldridge, Ph.D.
Introducing In Vitro ADMET Studies Earlier
David Daniels, Ph.D.
GPCRs Remain “Hot” Drug Targets
Elizabeth Lipp
Bioprocess Advances Aim to Streamline Operations
Vicki Glaser
Versatility Concerns Impact Facility Design
Angelo DePalma, Ph.D.
Quantification & Identification in Proteomics
Vicki Glaser
Tools for Protein Structure Characterization
K. John Morrow Jr., Ph.D.
Court Blocks PTO-Initiated Patent Reform
Courtenay C. Brinckerhoff
Cancer Stem Cells: Fact or Fiction
George L. Gabor Miklos, Ph.D.
Phillip J. Baird, M.D., Ph.D.
Ian E. Haines, M.D.
Boosting Microplate Reader Functionality
Franka Ganske, Ph.D.
Michael Fejtl, Ph.D.
Marjan Orban, Ph.D.
Use of Continuous Plate Reactor Technology
Barry Johnson, Ph.D.
Johan Persson
Tom Thane Nielsen
Biosimilars Are Poised to Influence the Industry
Viren Mehta, Pharm.D.
Eric Snyder, Ph.D.

April 15, 2008 (Vol. 28, No. 8)
Combining Microscopy with In Vivo Imaging
Timothy Alan Sutton, M.D., Ph.D.
Kenneth William Dunn, Ph.D.
Cell-Based Assay Utilization Is On the Upswing
Shankar Sellappan, Ph.D.
Anthill Addresses Chemical Synthesis Needs
Carol Potera
Emerging Firms Highlighted at Roth Meeting
Ilene Schneider
Cell-Based Assay R&D Role Expands
Kathy Liszewski
Downstream Bottlenecks: Are They Myth or Reality?
Gail Dutton
HTS Carving Out Hit-to-Lead Position
Nina Flanagan
Roche All Set to Launch xCELLigence System
John Sterling
Increasing Yield in Nucleic Acid Sample Prep
Vicki Glaser
Managing Data from Next-Gen Sequencing
William Van Etten, Ph.D.
Creating a Life Science Cluster in Florida
Tamlyn Oliver
Celera Readies Itself for Possible Spin-Off
Querida Anderson
Using DNA Traceability to Track Meat and Ensure Safety
Patrick Cunningham, Ph.D.
Quantifying Pipette Variability due to Humidity
Doreen Rumery
Producing Proteins for New Drug Development
Soon Seog Jeong, Ph.D.
Hui Feng, Ph.D.
Gabriel Cubberley
Maria Borovilos
Development of an Ion-Exchange Process
Anthony R. Newcombe, Ph.D.
Claire Newcombe
Richard Francis

April 1, 2008 (Vol. 28, No. 7)
Studying Protein Interactions in Living Cells
Ryan D. Bomgarden, Ph.D.
Aging ELISA Realm Takes Benchmark Role
Christianne Bird
Increasing the Odds of In Vitro Fertilization
Carol Potera
Saskatchewan Looks Past AgBiotech Roots
Carol Potera
Cancer Biomarkers Expedite Detection
K. John Morrow Jr., Ph.D.
Regulations Still Driving Stability Testing
Angelo DePalma, Ph.D.
Revolutionizing Protein Expression in R&D Arena
Elizabeth Lipp
Metabolomics Studies Rise in Quality
Susan Aldridge, Ph.D.
New Solutions Make qPCR a Rapidly Advancing Field
David Daniels, Ph.D.
U.S. Gene Patents in Legal Limbo –– for Now
Janis K. Fraser, Ph.D.
Defending Pharma Companies
J. Leslie Glick, Ph.D.
Removing Color Impurities in Biomanufacturing
Jon Fisher
Amie Gehris
John Maikner
Biobanks Can Make or Break Biomarkers
Kevin Krenitsky, M.D.
Combined Correctness Can Enrich Proteomics
Ola Forsstrom-Olsson
Anna Kapferer
Alzheimer’s Market Set to Grow Substantially
Rod Raynovich

March 15, 2008 (Vol. 28, No. 6)
Machine Vision Improves HTS Quality Control
Jason Cassaday
Growth Foreseen for Ophthalmology Sector
Hermann A. M. Mucke, Ph.D.
Fermentas Learned Fast How to Go Global
Ilene Schneider
Cellectar’s 3-Step Process to Target Tumors
Carol Potera
Funding Issues Stymie Pandemic Preparation
Sue Pearson, Ph.D.
Getting More Out of Poor RNA Samples
Kathy Liszewski
Applications Broaden for Epitope Mapping
K. John Morrow Jr., Ph.D.
New Products Expand Use of Disposables
Angelo DePalma, Ph.D.
Fragment-Based Approach Increases Leads
Elizabeth Lipp
Surmounting Small Molecule Challenges
Nina Flanagan
Automating and Unifying Lab Workflow
Ilene Schneider
Protein Microarray Uses Abound
Vicki Glaser
CROs Step Up Activities in Developing Countries
Gail Dutton
Paucity of Biopharma Approvals Raises Alarm
Ronald A. Rader
Monogram Enters Theranostic Market
Querida Anderson
Designing Improved Humans
Henry I. Miller, M.D.
Fine-Tuning Compound Safety Assessments
Richard Brennan, Ph.D.
Identifying MRSA with Multiplex Sequencing
T. Vinayagamoorthy, Ph.D.
Roger Hodkinson
Metabolic Monitoring Enhances Production
Bo Xu, Ph.D.
Jens Gram, Ph.D.

March 1, 2008 (Vol. 28, No. 5)
Development of a Real-Time Immunoassay
Jean-Francois Houle, Ph.D.
Paul Smith
qRT-PCR Ready for Rapid Growth Worldwide
Shankar Sellappan, Ph.D.
Solutions for Automating a Cell Culture Process
Susan Aldridge, Ph.D.
Staying Focused on Rodent-Breeding Business
Carol Potera
Life Science Compensation Trends Upward
Bryan Pearce
Oulu Region Lures Biotechnology Firms
Susan Aldridge, Ph.D.
Tapping miRNA-Regulated Pathways
Vicki Glaser
Small Biotechnology Firms Reach Out to CROs for Help
Nina Flanagan
Pharmaceutical Manufacturing Goes Green
Vicki Glaser
Innovations Mark Biosensor Development
K. John Morrow Jr., Ph.D.
Next-Generation Sequencing Picks Up Pace
Lloyd Dunlap
Optimizing Transient Gene Expression
K. John Morrow Jr., Ph.D.
Diagnostics Advancing Healthcare Reform
John F. Wong, Ph.D.
Protecting Inventions in the U.S. and Europe
Courtenay C. Brinckerhoff
“MAP” for Improving Drug Testing
John J. Pippin, M.D.
Stabilizing Protein-Folding Conformations
Gene W. Lee, Ph.D.
Versatile, Label-Free Microarray Analysis
Voula Kodoyianni, Ph.D.
Tool Firms Set Up to Defy Economic Downturn
John L. Sullivan

February 15, 2008 (Vol. 28, No. 4)
Increasing Specificity in Transporter Assays
Ismael Hidalgo, Ph.D.
Pediatric Market Offers Multiple Opportunities
Bruce Carlson
Automating Clone Picking in Bioproduction
Susan Aldridge, Ph.D.
BrainCells Bets on Small Molecule Therapies
Ilene Schneider
LC Applications Are Expanding
Angelo DePalma, Ph.D.
Top 60 Chinese Biofirms Propel Industry Forward
Eliza Yibing Zhou
Lab-Asset Management Gets Smarter
Gail Dutton
Improving Service-Provider Performance
Michael Webster
Tips for Building a Core Genotyping Facility
Vicki Glaser
Novel Approaches to Engineer Antibodies
K. John Morrow Jr., Ph.D.
London Strives to Be Global Biotech Hub
Susan Aldridge, Ph.D.
Partnerships Expedite Product Advancement
Stewart Lyman, Ph.D.
Patients Shortchanged by Big Pharma
Marc-André Gagnon
Industrial Manufacturing of Plasmid DNA
Hans Huber, Ph.D.
Wolfgang Buchinger, Ph.D.
Josef Diewok, Ph.D.
Robert Ganja
Daniela Keller
Jochen Urthaler, Ph.D.
Roman Necina, Ph.D.
SNP Genotyping Aids Diagnostic Development
Steven Dodsworth, Ph.D.
Hastening Epitope Discovery for Vaccines
Nikolai Schwabe, Ph.D.
Amanda Turner

February 1, 2008 (Vol. 28, No. 3)
Company Update: Protagen Zeroes In on Protein Therapeutics
Sophia Fox
Trubion Tackles Second-Generation mAbs
Carol Potera
GEN’s Annual Wall Street Analyst Roundup
BioMarket Trends: Phalanx of Treatments Propels Burn Market
Bruce Carlson
DNA Methylation Bolsters Cancer Research
Nina Flanagan
Winning the Contamination Control Battle
Angelo DePalma, Ph.D.
Stem Cells Advance on Multiple Fronts
Elizabeth Lipp
Driving Discovery from Inside Out
Kathy Liszewski
qPCR Poised for Prime Time
Lloyd Dunlap
New Act Endangers Long-Term Patent Validity
Beverly Lubit, Ph.D.
Firms Need to Focus on Profits
Henry I. Miller, M.D.
Streamlining Gene Delivery with Microporation
MinSung Kim
Neoncheol Jung, Ph.D.
Assay: Single-Molecule Sequencing Advances
Avak Kahvejian, Ph.D.
Combination Therapies Fortify Oncology Fight
Mark Hickinson, Ph.D.
Nate Cosper, Ph.D.
Aiming at Easier Scale-Up in Protein Production
Brian Dalby, Ph.D.
Chaoting Liu
Weixing Chen, Ph.D.
Henry C. Chiou, Ph.D.
Web Exclusive: GEN’s Annual Wall Street Roundup

January 15, 2008 (Vol. 28, No. 2)
Affitech Exploits Antibody Discovery Platforms
Susan Aldridge, Ph.D.
Company Update: GATC Solely Focused on Sequencing Services
Sophia Fox
Biomarket Trends: Molecular Diagnostics on the Move
Lucy J. Sannes, Ph.D.
Web Exclusive: Predicting the Future of the Bioreactor
Vijay Singh, Ph.D.
Tech Focus: Prognosticating the Future of the Bioreactor
Vijay Singh, Ph.D.
Turning Targets into Drug Products
Gail Dutton
Time-Resolved FRET Gains in Popularity
Kate Marusina, Ph.D.
Biobanking Needs More Standardized Procedures
Elizabeth Lipp
RNAi Gene Silencing Applications Advance
Vicki Glaser
Capitalizing on Biomarker Discovery Work
Trevor Stokes
Jump-Starting Bioprocessing Sector in U.K.
Susan Aldridge, Ph.D.
Changing Needs Drive the Media Market
Angelo DePalma, Ph.D.
Revamping Recovery & Purification Strategies
K. John Morrow Jr., Ph.D.
Improving Protection of Trial Participants
Jonathan E. Rackoff, J.D.
Namrata Kotwani
Optimizing the Rapid Production of Vaccines
Silke Fetzer
Establishment of a Sustainable Biobank
Steve Arsenault
Kerri McWeeny
Denis Bilodeau
Daniel Gaudet, M.D., Ph.D.
Novel Platform Enables Shotgun Proteomics
Brian M. Balgley, Ph.D.
Cheng S. Lee, Ph.D.
Assay: Hybrid Bridges the Microplate Reader Gap
Mickie Henshall
Paul Held, Ph.D.

January 1, 2008 (Vol. 28, No. 1)
Expanding Antibody Therapeutic Options
Carol Potera
BioMarket Trends: Orphan Drug Arena Driven by Biologics
Syamala Ariyanchira, Ph.D.
Tech Note: Delivery of Functional Proteins Inside Cells
Laurent Meunier, Ph.D.
Stephane Moutard, Ph.D.
Olivier Zelphati, Ph.D.
Addressing Unmet Type 2 Diabetes Needs
Allan B. Haberman, Ph.D.
Siemens’ Science and Technology Awards
Getting a Handle on Nanobiotech Products
Vicki Brower
High-Content Discovery Analysis
Kathy Liszewski
Repositioning Idle Drugs via Systematic Serendipity
Gail Dutton
Systems Biology Alters Drug Development
Nina Flanagan
Unlocking the Secrets of Protein Profiling
Elizabeth Lipp
Complex Peptides Challenge Manufacturers
Vicki Glaser
DTC Campaigns Mislead Public
Karina L. Brierley
Ellen T. Matloff
Assay: Mimicking Cellular Behavior in Capillaries
Kate Fitzgerald, Ph.D.
Total RNA Purification for Real-Time RT-PCR
Jasmin Gibson
Ken Doyle, Ph.D.
Julie Kramer
Integrity Testing of Large-Size Filter Systems
Matthew Daley
Jibin Hao
Making Personalized Medicine a Reality
Lisa A. Haile, J.D., Ph.D.

December 1, 2007 (Vol. 27, No. 21)
Novozymes Tackles Ingredient Manufacture
Carol Potera
Biomarket Trends: LIMS Growth Driven by Replacement Purchases
Jonathan Witonsky
Biotech Aims High in the Lone Star State
Vicki Brower
Erecting Exclusivity Barriers with Innovation
Douglas Martin, M.D.
Finding Your Place as an Industry Scientist
Tamara Zemlo, Ph.D.
ADMET Issues Slow Discovery
Elizabeth Lipp
Sample Storage Requires Regular Tweaking
Nina Flanagan
Broadening Genetic Tests in the Consumer Market
Kate Marusina, Ph.D.
Obstacles to Exploitation of miRNA Falling
Catherine Shaffer
Lyophilization Advances Improve Recovery
K. John Morrow Jr., Ph.D.
Enlisting CROs for Clinical Trial Assistance
Gail Dutton
Patent Ambushing Sullies Standard Setting
Wim Nauwelaerts
Antisocial Bio-Activism
Henry I. Miller, M.D.
High-Performance Melting Curve Analysis
Michael Hoffmann
Jochen Hurlebaus
Christian Weilke
Assay: Analyzing Lipid-Modifying Enzymes
Jonas Ekblom, Ph.D.
Jun Wu, Ph.D.
Jeff Koehler, Ph.D.
Elizabeth Rietz
Optimization of Electroporation Parameters
Natascha Weiss
Wolfgang Bielke, Ph.D.
Peter Hahn, Ph.D.
Planning and Designing Biopharma Plants
Karin Koller
Industry on Target for a Successful Year
G.Steven Burrill

November 15, 2007 (Vol. 27, No. 20)
Invitrogen Taps Into Cell Biology Expertise
Carol Potera
BioMarket Trends: Application of RFID Can Save Time and Money
Bruce Carlson
Letter to the Editor: What About Tysabri as an MS Treatment?
Eurofins MWG Consolidates Companies' Offerings
Sophia Fox
Improved Screening for Better Lead Generation
Lloyd Dunlap
Getting a Handle on Signal Transduction
Kathy Liszewski
Seeking the Big Picture with Microarrays
Gail Dutton
Innovations in Membrane Filtration Tools
Angelo DePalma, Ph.D.
Advancing Cancer Vaccines
Sue Pearson, Ph.D.
Army Hospital Reborn as Bioscience Park
Carol Potera
Sizing Up Genzyme's Takeover Potential
Subsidizing Biofuels Is Not the Answer
William K. Jaeger, Ph.D.
Characterizing Stable Protein Formulations
Sigrid Kuebler
TF Profiling in Drug Discovery
Fiona Coats, Ph.D.
James Lazar, Ph.D.
Sherry Challberg, Ph.D.
ApplicationNote: Dendritic Cell-Based Immunotherapeutics
Fred Miesowicz, Ph.D.
Enhancing Performance in Cell Culture
James Babcock, Ph.D.
Shawn Smith
Hans Huttinga
Debra Merrill

November 1, 2007 (Vol. 27, No. 19)
Millipore's Acquisitions Enhance Offerings
Carol Potera
BioMarket Trends: Liquid Chromatography Market Proliferates
Shankar Sellappan, Ph.D.
Leveraging Impact of Biodefense Contracts
Gail Dutton
Fragment-Based Discovery in Spotlight
Elizabeth Lipp
Pushing Toward a $1,000 Genome
Vicki Glaser
Use of LC Grows in MS Sample Prep
K. John Morrow Jr., Ph.D.
Weighing In On Genetic Testing & Research
Joan Zimmerman
Boosting Use of Microbial Systems in Manufacturing
Sue Pearson, Ph.D.
New Approaches Push Antibodies Ahead
Nina Flanagan
Defining Bench to Bedside Success
Lynn Sutherland
Tough Road for Biotech Patent Prosecution
Fangli Chen, Ph.D., J.D.
Brian A. Fairchild, Ph.D.
POINT OF VIEW: Genetically Modified Foods Unsafe? Evidence that Links GM Foods to Allergic Responses Mounts
Jeffrey M. Smith
ApplicationNote: New Tool Refines Tissue Homogenization
Hong Gao
Stephanie Thompson
Romain Verollet
Antonin Duval
Removing Entrenched Bottlenecks in HCS
Mark A. Collins, Ph.D.
Assay: Measurement of Mitochondrial Function
David Ferrick
Steve Chomicz
Min Wu
Characterizing Culture Process Dynamics
Geoffrey Esteban
Tackling Financing Challenges in Biotech
Ron Cohen, M.D.

October 15, 2007 (Vol. 27, No. 18)
HPLC Column Provider Expands Focus
Carol Potera
Application of Real-Time qPCR Broadens
Vicki Glaser
Disease Pathway Analysis
Joan Zimmerman
Reducing Attrition with Image Analysis
Susan Aldridge, Ph.D.
Overcoming Size Concerns in Cell Culture
Angelo DePalma, Ph.D.
Biologics Force Changes in Stability Testing
Gail Dutton
China Expanding Bioresearch Activities
Vicki Glaser
ServiceNote: Human Tissue Research for Drug Discovery
Amanda J. Woodrooffe, Ph.D.
Robert A. Coleman, Ph.D.
BioMarket Trends: Process Improvements Bolster Peptide Drug Market
Ramin Saberi
Anil Sehgal, Ph.D.
Ventana Says Its Is Worth More Than $3B
Querida Anderson
Preparedness for Bioterrorism
Rae Lyn Burke, Ph.D.
Making RNA More Durable at Room Temp
Sharron Ohgi
Application Note: Continuous Cell Profiling Technology
Elke Thedinga, Ph.D.
Michael Schulze, Ph.D.
Assay: New Substrates for FRET-Based Assays
Vera Rakhmanova, Ph.D.
Rich Meyer, Ph.D.
Xiaohe Tong
Microbe Expression Requires Flexibility
Bo Kara
Ian Hodgson

October 1, 2007 (Vol. 27, No. 17)
Alpha Biologics Takes Global Approach
Sophia Fox
Revamping Drug Discovery Strategies
Patricia F. Dimond, Ph.D.
Cytometry Drives New Business Models
K. John Morrow Jr., Ph.D.
Personalized Medicine Seeks Mainstream
Elizabeth Lipp
CMOs Focused on Meeting Needs and Time Lines
William Downey
Producing Biologics Less Expensively
Sue Pearson, Ph.D.
Transforming Healthcare With Stem Cells
Susan Aldridge, Ph.D.
Benefits Point Biotech Firms to Buffalo
Vicki Brower
Biomarket Trends: Four Therapies Dominate MS Treatment
Melissa Elder
IP May Be a Tonic for Distressed Companies
Ronald S. Gellert
Gregory J. Urbanchuk
Risk-Averse Behavior Entrenched at FDA
Henry I. Miller, M.D.
Automated Target Preparation Solution
Zhu Zhu
Handy Yowanto, Ph.D.
Keith Roby
Assay: Validating Biomarkers with VeraCode
Mickie Henshall
Elliott Gorfain
Application Note: High-Throughput Process Development
H.Brett Schreyer
Scott E. Miller
Seth Rodgers
Use of Perfusion Technology on the Rise
Bruce Jon Compton, Ph.D.
Jacob Peter Jensen
Ways to Address Neglected Disease Issue
Cecilia Chan

September 15, 2007 (Vol. 27, No. 16)
Start-Up Firm Touts Mid-Stage Pipeline
Carol Potera
Biomarket Trends: Proteomics Sample-Prep Market Is Ripening
Jonathan Witonsky
Application Note: Strategies for the Culture of CHO-S Cells
Kevin A. Auton, Ph.D.
Julie A. Bick, Ph.D.
Ian M. Taylor, Ph.D.
The Game Plan for Sigma's Research Biotech
Expediting Biomarker Advances
Joan Zimmerman
Ways to Arm Antibodies Under Increasing Scrutiny
K. John Morrow Jr., Ph.D.
Capitalizing on microRNA Expression
Kathy Liszewski
Moving Biotechnology Forward with PAT
Susan Aldridge, Ph.D.
Disposables Reach Out to New Markets
Nina Flanagan
Flanders Striving to Attract Biotechnology
Querida Anderson
Pfizer Deal Pulls Xoma Out of August Slump
Querida Anderson
Too Many Mice, Too Few Pathologists
Robert D. Cardiff, MD, Ph.D.
Bruce W. Altrock, Ph.D.
New Kit Facilitates Small RNA Cloning
Eric J. Devor, Ph.D.
Assay: Laser-Scanning Cytometry in Oncology
Paul Wylie, Ph.D.
Cultivating Anchorage-Dependent Cells
Jose Castillo
Steven Vanhamel

September 1, 2007 (Vol. 27, No. 15)
Corning Targets Screening & Cell Growth
Carol Potera
Biomarket Trends: Pharmaceutical Industry Undergoing Transformation
Steve Arlington
Anthony Farino
Operating Costs for Regional Clusters
John H. Boyd
Malaysian Gov't Fosters Biotech Growth
Robert Yuan, Ph.D.
Accelerator MS Is a Powerful New Tool
Kate Marusina, Ph.D.
Advancing Most Promising Compounds
Elizabeth Lipp
Use and Support of Forensics Flourishes
Gail Dutton
Transforming Transfection Technology
Patricia F. Dimond, Ph.D.
Process Analytics Remains Elusive Goal
Angelo DePalma, Ph.D.
Techniques to Ramp Up Protein Purification
Vicki Glaser
Stem Cell Firms Struggle for Financing
Gail Dutton
Molecular Imaging in Drug Development
Amit Agarwal
Biopharmaceutical IP Protection in China
Susan B. Fentress
Is Biomass the New Texas Tea?
Peter C. Lauro
Amplification of RNA from FFPE Tissues
Paul Siebert, Ph.D.
Ligand Enrichment and Profiling Method
Lyle Rice, Ph.D.
Debra Cen, Ph.D.
Combating Mycoplasmal Contamination
Claire Scholfield, Ph.D.
Anne Cox, Ph.D.
Anthony Pitt, Ph.D.
VC Funding Trends for Life Science Firms
Robert Dellenbach

August 1, 2007 (Vol. 27, No. 14)
Thermo Fisher Targets Lab Solutions
Carol Potera
Biomarket Trends: Pain Therapeutics Sector Ripe with Potential
Ken Rubenstein, Ph.D.
Company Update: Engineering Solutions for Drug Discovery
Susan Aldridge, Ph.D.
Application Note: Internalization and Protein Relocation
Andreas Brecht, Ph.D
Olivier Roumanie, Ph.D.
Kathrin Muntener, Ph.D.
Using AMDE Data to Cut Drug Toxicology Failures
Gail Dutton
Cell-Based Research Gains Momentum
Elizabeth Lipp
Effective Optimization: Fight or Flight?
Lloyd Dunlap
Biomarkers Transform R&D
Kate Marusina, Ph.D.
Improving Protein Production Processes
K. John Morrow Jr., Ph.D.
Nurturing Growth of mAb Therapeutics
Catherine Shaffer
Demand Strong for Upstream Systems
Vicki Glaser
Strategies for Ensuring Optimal Scale-up
Angelo DePalma, Ph.D.
Trends in Mass Spec: Understanding a Drug's Metabolic Profile
K. John Morrow Jr., Ph.D.
Trends in Mass Spec: Roundtable Discussion on MS Analysis
Quest Continues for Innovations in HPLC
Susan Aldridge, Ph.D.
USPTO Rejects WARF's ESC Patents
Lisa A. Haile, J.D., Ph.D.
Stacy Taylor
War on Cancer Is Being Oversold
Ralph W. Moss, Ph.D.
Debunking Downstream Bottleneck Myth
Gunter Jagschies, Ph.D.
Ann O'Hara
Animal Models for Clinical Advancement
Colleen Jonsson, Ph.D.
Assay Tutorial: Engineering Lab-Friendly Lipid Assays
Paul Neilsen, Ph.D.
Colin Ferguson, Ph.D.
James Thompson
Angie M. Branch
Andy Miller
Biotech Investing a Marathon Not a Sprint
Rod Raynovich

July 1, 2007 (Vol. 27, No. 13)
Goodwin Biotechnology Expands to India
Carol Potera
Biomarket Trends: A Myriad of Approaches Fosters Growth in Early Tox Testing
Steven Heffner
Screening Technologies & Enabling Instrumentation
K. John Morrow Jr., Ph.D.
Magnetic Beads for Biomarker Discovery
Nina Flanagan
Whole Genome Amplification Strategies
Elizabeth Lipp
Increasing Capacity for GMP Peptides
Vicki Glaser
Designing Better Purification Schemes
Angelo DePalma, Ph.D.
CROs Cut Costs for Biotechs
Kathy Liszewski
Transforming Information into Knowledge
Gail Dutton
Technote: Addressing Trace Protein Detection
David Hammond, Ph.D.
KSR: A Bump in the Road for Biotech?
Courtenay C. Brinckerhoff
Biotech Business Model Thrives
J. Leslie Glick, Ph.D.
Disposable Mixing System Applications
Annemarie Braun
George Oulundsen
Parallel Glycoprotein N-glycan Analysis
Nico Callewaert, Ph.D.
Steven Geysens, Ph.D.
Wouter Laroy, Ph.D.
Multiplexed Gene-Expression Assays
William Radany, Ph.D.
Assay: Achieving High-Throughput Mass Spec
Can C. Ozbal, Ph.D.
Assessing the Life Sciences Tool Market
Arshad Ahmed

June 15, 2007 (Vol. 27, No. 12)
Nereus Prospects Oceans for Cancer Drugs
Carol Potera
Opening the Gates on Ion Channel Drugs
Kathy Liszewski
Reducing Attrition in Late-Stage Development
Susan Aldridge, Ph.D.
Multiplexing Methods Head to Clinic
Kate Marusina, Ph.D.
Improving Drugs with Protein Engineering
Trevor Stokes
Managing Cell-Line Optimization Process
Gail Dutton
Achieving Better Isolation of Nucleic Acids
Lloyd Dunlap
China Cultivates Its Healthcare Industry
Robert Yuan, Ph.D.
BioMarket Trends: Genomics & Impending Market Revolutions
Jonathan Witonsky
OSI Pharma Needs to Expand Pipeline
Querida Anderson
Genetic Diagnosis and Wrongful Life
Kevin Costello
Array Tape for Miniaturized Genotyping
Elaine May, MD
Magnetic Bead-Based Sample Preparation
Arja Lamberg, Ph.D.
Identification of High-Producing Clones
Michael Wathen, Ph.D.
Bradley Dalton
Mark Gerber, Ph.D.
Kevin J. Kayser, Ph.D.
James S. Ross
Matthew V. Caple

June 1, 2007 (Vol. 27, No. 11)
Lentiviral Vector Assists Gene Therapy
Carol Potera
Biomanufacturing in Limelight
Susan Aldridge, Ph.D.
DNA Chips Provide Key to Human Genome Analysis
Nina Flanagan
Cellulosic Biofuels Abound with Promise
Gail Dutton
Advances in Structure-Based Drug Design
Elizabeth Lipp
miRNA Becoming a Research Priority
Catherine Shaffer
SPR Expands the Knowledge of Proteins
Gail Dutton
Streamlining HPLC in Bioproduction
Angelo DePalma, Ph.D.
BIO 2007 Challenges Attendees to Innovate
Ilene Schneider
Long-Term Time-Lapse Studies Focus on Cells
BioMarket Trends: Diabetes Market Opportunities Soaring
Steven Heffner
Company Update: Ludesi Proffers Software and Services
Sophia Fox
Offshoring Your Intellectual Property
Bart Bassett
Sergio Garcia
Follow-On Biologics Policy Needs Science
Henry I. Miller, M.D.
Mass Spectrometry for Metabolomics
Steve Fischer
Assay: 3-D Cell Colony Assays for HTS Studies
Steven C. Miller, Ph.D.
Evan F. Cromwell
Biopharmaceutical Purification Strategies
Pranavan Thillaivinayagalingam
Eli Keshavarz-Moore
Biopharma Sector Leadership in Transition
Benjamin J. Conway

May 15, 2007 (Vol. 27, No. 10)
CVBT Banks on Fibroblast Growth Factor
Carol Potera
Kinase Assays' Therapeutic Potential
Lloyd Dunlap
Development of Peptide Drugs Advances Briskly
Gail Dutton
miRNA's Role Rises in Drug Research
Kathy Liszewski
Mass Spec Protein Analysis Strategies
K. John Morrow Jr., Ph.D.
Improving Yields in Oligo Manufacturing
Vicki Glaser
Probing the Biology of Cancer Stem Cells
John F. Wong, Ph.D.
Pharmacovigilance Impacts Drug Safety
Mike Mentasana
BioMarket Trends: The Future of Genome Synthesis and Design
Rob Carlson, Ph.D.
Jim Newcomb
Steven Aldrich
Sangamo Poised to Earn Steady Revenues
Querida Anderson
Drug Delivery Fuels Specialty Pharma
Felix Theeuwes
Toxicogenomics for Compound Selection
Megan Laurance, Ph.D.
Brigitte Ganter, Ph.D.
Assay: Cytotoxic Cell Effector Function Studies
Lisa B. English, Ph.D.
Katherine Gillis
Dianne Fishwild
Affinity Tagging for Protein Purification
Lee Olech

May 1, 2007 (Vol. 27, No. 9)
Improving Pharma Process Operations
Sophia Fox
Company Update: Blue Gene Tackles Disease and Migration
Carol Potera
Biomarket Trends: Cell Culture Landscape Changes Rapidly
Steven Heffner
China Looks to Accelerate Globalization
Robert Yuan, Ph.D.
So, You Want to Be a Millionaire?
Gail Dutton
Navigating Complex Pathways in Cancer
Elizabeth Lipp
Building Better Pipelines with ADME-Tox
Vicki Glaser
Molecular Diagnostics Revamps Drug Development
Kate Marusina, Ph.D.
Protein Characterization Entering New Era
Nina Flanagan
Optimized Facility Design and Utilization
Angelo DePalma, Ph.D.
BioSimilars Market Ripe for Expansion
Sue Pearson, Ph.D.
Gene Patents Jeopardize Genetic Testing
Roger Klein, MD, JD
Curing Cancer: Running on Vapor
Mike Mentasana
Phillip J. Baird, M.D., Ph.D.
Assay Tutorial: Side-Effect Database for Reducing Toxicity
Ming Liu, Ph.D.
Hao Chen, Ph.D.
Precision Nanoliter Aqueous Transfer
Jean Shieh
Siobhan Pickett
Joseph Olechno
HCDF as a Protein Labeling Methodology
Sebastian Fiedler
Christof Knocke
Jennefer Vogt
Harmut Oschkinat
Anne Diehl

April 15, 2007 (Vol. 27, No. 8)
SynCo Bio Partners Is Poised for Expansion
Carol Potera
Biomarket Trends: Shape of RNAi Screening Is Changing Rapidly
Jonathan Witonsky
Company Update: Banking on Human Embryonic Stem Cells
Folding@home Adopts PlayStation 3
Companies Step Up to GPCR Challenge
Susan Aldridge, Ph.D.
Entering the Promising World of Metabolomics
Gail Dutton
Harnessing RNAi's Gene-Silencing Power
Kathy Liszewski
Techniques for Characterizing Biologics
Aicha Otmani, Ph.D.
Fenton Fong
Enterprising Polymer Delivery Methods
Vicki Brower
Pharmaceutical Operations Expand in China
Robert Yuan, Ph.D.
Biosimilars Jumpstart Biotech in India
Nalini Motwani, Ph.D.
Moving Immunology Research Forward
Alan Koop
Acadias CNS Pipeline Propels Growth
Querida Anderson
Searching for Viable Biobusiness Models
Gary P. Pisano, Ph.D.
Nuclear Imaging Drug Development Tools
Lynn Buchanan, Ph.D.
Paul Jurek, Ph.D.
Russ Redshaw
Assay: Miniaturizing GPCR-Signaling Studies
Sarah Schultz
Tracy Worzella
Large-Scale Affinity Chromatography
Frank Detmers
Pim Hermans
Mark ten Haaft

April 1, 2007 (Vol. 27, No. 7)
Acceleron Takes on Bone & Muscle Repair
Carol Potera
Company Update: GE Cultivates Its Life Sciences Business
Carol Potera
BioMarket Trends: Promises and Challenges of Pharmacogenetics
Harry Glorikian
Technote: The State of Microsample Quantitation
David Ash
Philippe Desjardins
Advances in Epitope Tagging Strategies
K. John Morrow Jr., Ph.D.
CGH for Detecting Copy Number Variation
Vicki Glaser
Designing Out Up-& Downstream Mismatches
Angelo DePalma, Ph.D.
Combating Ocular Disease
Elizabeth Lipp
Regenerative Medicine Enters Realm of Reality
Nina Flanagan
Keeping an Eye on Rising Biotech Firms
Kenneth H. Buetow, Ph.D.
Streamlining Biomarker Validation Activities
Vicki Glaser
In Defense of Gene Patenting
Geoffrey M. Karny
Glycoanalysis of Recombinant Proteins
Peter Porschewski, Ph.D.
Thibault Geoui, Ph.D.
Assay: High-Throughput DNA Methylation
Peter W. Laird, Ph.D.
Marina Bibikova, Ph.D.
Jian-Bing Fan, Ph.D.
Improving Quality in Cryopreserved Cells
John M. Baust, Ph.D.
Ana Maria Pardo
Todd Upton, Ph.D.
New Funding Model for Start-Ups
Barbara S. Schilberg

March 15, 2007 (Vol. 27, No. 6)
AVI Is Taking Antisense Drugs to the Clinic
Carol Potera
Biomarket Trends: Proteomics Arrays Offer Wide Applications
Jonathan Witonsky
Funding Embryonic Stem Cell Research
Sigrid Fry-Revere
Cell Signaling Pathway Analysis
Patricia F. Dimond, Ph.D.
Evaluating Data Flow in Systems Biology
Kate Marusina, Ph.D.
Chemogenomics Reveals New Synergies
Kathy Liszewski
Protein Microarray Market Scope Broadens
Vicki Glaser
Designing & Running Multiproduct Facilities
Gail Dutton
Ten Years After Dolly: Where Are We?
Sophia Fox
Are Kinase Inhibitors Poised for Success?
Peter Lassota
Mark Roskey
Labeling Can Restore the Public's Trust
Rebecca Spector
Assay: Accuracy and Precision with Serial Dilution
Joseph W. Barco
Manuel Gomez
Joseph P. Karbowski
Ian Yates
Multiplex Analysis of Drug Toxicity Markers
Jane Luo, Ph.D.
Han-Chang Chi
Michael Gary Jackson
Yong Yu
Kahaku Oades
Patrick Pezzoli
Gordon Vansant
Scott Boyer
Disposable Large-Scale Pressure Sensors
Jim Furey

March 1, 2007 (Vol. 27, No. 5)
Nanoxis Focuses on Membrane Proteins
Sophia Fox
BioMarket Trends: Mass Spec Finds a Niche in Biomarkers
Justin Saeks
Company Update: Advaxis Explores New Cancer Vaccines
Automation Technologies Drive Solid-Phase Extraction
Gail Dutton
Technote: Integrated Data Access, Analysis & Support
Kathleen Mensler
qPCR Methods Are Continuing to Evolve
Nina Flanagan
Safety/Toxicity Issues in Drug Discovery
Elizabeth Lipp
Application Note: Column-Free Solutions For Purification
Bruce W. Jarvis, Ph.D.
Haiyang Gruenwald, Ph.D.
Novel Methodologies Allow Greater Accessibility to qPCR
Nicholas D. Rose
Strategic Protein Production
K. John Morrow Jr., Ph.D.
Formulation: One Ingredient for Success
Angelo DePalma, Ph.D.
China Pharma Basking In Its Spotlight
Eliza Yibing Zhou
Biotech Has Larger Role in Providing Clean Energy
Susan Aldridge, Ph.D.
Supplement Article: RT-PCR Enters the Realm of Stochastic Gene Expression
Licensees May Be Gaining a New Legal Weapon
Richard B. Smith
Labeling Cloned Food Is Unnecessary
Henry I. Miller, M.D.
Quantifying Changes in Cellular Energetics
David Ferrick, Ph.D.
Andy Neilson
Min Wu, Ph.D.
Steve Chomicz
Assay: Optimizing RT-PCR for Pathogen Detection
Steve Harrison
Graham Lidgard, Ph.D.
Host Strain Development for Proteins
Diane M. Retallack
Charles H. Squires
Late-Stage Cancer Vaccines Set to Launch

February 15, 2007 (Vol. 27, No. 4)
Bioengineering Bacteria for Drug Delivery
Carol Potera
BioMarket Trends: Diagnostic Tools Change Cancer Treatment
Harry Glorikian
Role Grows for HPLC in Discovery
Kathy Liszewski
Label-Free Biosensors Show Early Promise
K. John Morrow Jr., Ph.D.
New Methods Get SNPs Closer to Clinic
Trevor Stokes
Regulation Shifts from Product to Process
Vicki Glaser
Optimizing Antibody Biomanufacture
K. John Morrow Jr., Ph.D.
Techniques for Cell Culture Improvement
Susan Aldridge, Ph.D.
Embryonic Stem Cells: Not Just From Humans
Sue Pearson, Ph.D.
Stem Cells for Discovery & Development
Susan Aldridge, Ph.D.
Laboratory Asset Management Is Thriving
Gail Dutton
Dr. Reddy's Revenues Hit the $1B Milestone
Querida Anderson
Building a Bioscience Cluster
Bill Fair
Monolithic Columns for Biomolecule Analysis
Srinivasa Rao, Ph.D.
Nathan Bach, Ph.D.
Assay: Perfect Match Versus Single-Base Mismatch
Ramin Saberi
Base-Tolerant Affinity Resin for Mabs
Aman Mottaqui-Tabar

February 1, 2007 (Vol. 27, No. 3)
Aldagen Isolates Highly Active Stem Cells
Carol Potera
Biomarket Trends: Diversity Drives Use of siRNA
Tamara Zemlo, Ph.D.
Techniques to Overcome HTS Bottlenecks
Joan Zimmerman
$1,000 Genome Remains the Holiest
Kate Marusina, Ph.D.
RNAi Approaches for Target Validation
Patricia F. Dimond, Ph.D.
Disposables Win Downstream
Angelo DePalma, Ph.D.
Improving Protein Production Strategies
K. John Morrow Jr., Ph.D.
U.K. Working to Optimize Bioproduction
Susan Aldridge, Ph.D.
Diagnosis, Prognosis, and Therapy Selection
Elizabeth Lipp
Molecular Diagnostics Market Assessment
Alfred R. Doig
Puerto Rico Views Itself as a Bio Island
Carol Potera
Outsourcing Phase IV Pharma Research
GEN's Annual Wall Street Roundup
Rosalind Franklin Society Founding Board to Hold First Meeting
National Security and Scientific Research
Stephen M. Goodman
Automated Molecular Diagnostics
David H. Persing, MD, Ph.D.
Assay: High-Resolution Melting & Unlabeled Probes
Deepika deSilva
Jana Blackett
Genome Analysis: Microsatellites or SNPs
Michele A. Gilson, Ph.D.
Anatoli Tassis, Ph.D.
Linking Stainless and Single-Use System
John Boehm

January 15, 2007 (Vol. 27, No. 2)
Cell Therapeutics Counts on Drug Delivery
Carol Potera
BioMarket Trends: Cancer Vaccines Exhibit Potential
Bruce Carlson
Business Savvy for UK Biotechs
Susan Aldridge, Ph.D.
Making Sense of HCS Information
Lakshmi Kamath, Ph.D.
Robotic Solutions for Improved Lab Analysis
Ilene Schneider
RNAi-Based Gene Expression Manipulation
Trevor Stokes
Laser-Capture Microdissection Advances
Kathy Liszewski
Omics Prove Handy in Production Processes
Angelo DePalma, Ph.D.
Uniting Efforts in Molecular Medicine
Kenneth H. Buetow, Ph.D.
Avastin Pads Genentech's Bottom Line
Querida Anderson
Funding Challenges for Gene Therapy
Riku Rautsola, Ph.D.
Human Genome-Wide Association Studies
Tim Keith, Ph.D.
shRNAs Targeting Tumor Suppressor Genes
Diana Ji
Stacy L. Deeds
Edward J. Weinstein, Ph.D.
Managing Scale-Up of Recombinant Proteins
Ashley Wigley
Diane Wilkinson, Ph.D.
Dave Mead, Ph.D.

January 1, 2007 (Vol. 27, No. 1)
High-Resolution Oligo-Based CGH
Anniek De Witte
Christopher Rizzo
Francisco Cifuentes
SAFC Biosciences Expands Production
Carol Potera
BioMarket Trends: DNA Sequencing
Jonathan Witonsky
Reconstructing the Drug Discovery Pipeline
Elizabeth Lipp
Changing Game Plan for Protein Profiling
Nina Flanagan
Industrial Biotech Meets Systems Biology
Jose Manuel Otero
Lisbeth Olsson, Ph.D.
Jens Nielsen, Ph.D.
Serum for Cell Culture Out, Stem Cells In
Vicki Glaser
Offshoring R&D Activity
Vicki Glaser
What the New Congress Spells for Biotech
Gail Dutton
Therapeutic Cancer Vaccine Options
Sue Pearson, Ph.D.
The Basics of Patent Licensing Explained
Larry A. Roberts
Better Science Means Safer Food
Henry I. Miller, M.D.
Going Beyond Information Retrieval
Darryl Leon, Ph.D.
Novel Bioreactors for Fragile Glycoproteins
Silke Langhammer
Rene Brecht, Ph.D.
Uwe Marx, Ph.D.
Biotech's Changing Competitive Landscape
Viren Mehta, Pharm.D.

December 1, 2006 (Vol. 26, No. 21)
Bioanalytical Systems Targets CRO Niche
Finding and Working with a Staffing Firm
Lab Notebooks Offer Efficiency Gains
Gail Dutton
Honing in on signal Transduction Pathways
Gauging Nanobiotech's Promise Realistically
Research Drives Microscopy Innovations
Elizabeth Lipp
Collaborative Spirit Fosters Bioinformatics
Minimizing Cost and Use of Purified Water
Isolator Technologies Slowly Catching On
Angelo DePalma, Ph.D.
Marine Bioprospecting for Novel Drugs
Susan Aldridge, Ph.D.
BioMarket Trends
Abbreviated Approval of Generic Biologics
Market Research Tips for Suppliers
TechNote: Parallel Affinity-Based Sample Preparation
Matilda Almstedt
Jesper Hedberg, Ph.D.
Johan Ohman
Finding Modulators of the Hh Pathway
Systems Biology Tools Get Personal
Basic Considerations for Laboratory Water
Recent Growth Sets Stage for Q4 2006

November 15, 2006 (Vol. 26, No. 20)
Optimizing the Value of Potential Novel Drugs
Sample Prep Gaining Priority in Discovery
Nina Flanagan
The Next Generation of DNA Sequencing
Kate Marusina, Ph.D.
Filtration Technology Steps Up to Next Level
Product Technologies for Lyophilization
China-Grown Pharma Products
BioTime Bets on Blood Replacement
Gail Dutton
TechNote: High-Throughput DNA Extraction Solutions
Who Will Lead the Revolution?
Consistency from a Small Integrated System
Biospecimen Collection and Management
Genomic-Proteomic Cell Culture Approaches

November 1, 2006 (Vol. 26, No. 19)
GenoLogics Automates Omics for Labs
Can Pharma & Biotech Foil Counterfeiting?
Gail Dutton
Outsourcing Can Add Capacity & Expertise
Multidisciplinary Approach to RNAi
Antibody Engineering Methods Advance
Novel Vaccines Expand Potential Markets
Small Molecule Drugs
BioMarket Trends
Maximizing the Value of Biotech Patents
Biotech Production Is Blooming in the Tropics
Multiparametric Assays on Individual Cells
RNAi Libraries for Functional Genomics
Navigating the Postpreservation Viability Fog
Third Quarter Life Science Sector Review

October 15, 2006 (Vol. 26, No. 18)
BioMarket Trends
Company Update: Sequencing Technology Applications Expand
Maximizing Discovery Using Kinase
Microarrays Find their Way into the Clinic
Microrarray Standards Are the Next Step
Elizabeth Lipp
Safety Biomarkers Holy Grail of Toxicology
Kate Marusina, Ph.D.
Get Quality and Quantity in Your Process
Angelo DePalma, Ph.D.
Telemedicine Enables Better Care
Flexible Protein Microarray Inkjet Printing
Streamlining HTS for Challenging Targets
Rotating Bioreactors for Manufacturing

October 1, 2006 (Vol. 26, No. 17)
New Gene Sequencer Targets Productivity
BioMarket Trends
Inflammation Research Leads to Targets
Expanding Applications of Diagnostic Tools
Changing the Way Research Is Conducted
PCR Applications Continue to Expand
Elizabeth Lipp
New Software Tackles Mounds of Data
Bringing Pharmacogenomics into the Clinic
CMOs Aim to Boost Production Efficiency
Monoliths Seen to Revitalize Bioseparations
Connecting Basic Research and Patient Care
Susan Aldridge, Ph.D.
TechNote: Ratiometric Photometry for Calibration
Patent Rights in Biological Material
Making the Complex Simple
Isothermal Titration to Characterize Binding
Epitope Mapping and Vaccine Research
Ensuring Efficient Aeration of Cell Cultures
Life Sciences Strategic Deal-Making Trends

September 15, 2006 (Vol. 26, No. 16)
ExSAR Focuses on Discovery & Optimization
Company Update: ApoLife Touts Yeast-Based Expression System
BioMarket Trends: Biosensor Markets Outperform Expectations
European Biotechs Face a Funding Crisis
Biomolecular Screening Technologies
Maximizing Cell-Based Imaging Results
RNAi in Drug Discovery & Therapeutics
Kathy Liszewski
Bioprocess Simulations Gain Traction
Gail Dutton
Systematic Approach to Optimizing HPLC
Gail Dutton
Slow Adoption of PAT for Bioprocessing
Driving Standards in Single-Use Disposables
Preclinical R&D Investment Is Crucial to Long-Term Success
LOH and DNA Copy Number Changes
Overview of SmartFlow Tangential Flow Filtration
Minimizing Off-Target Effects in Transfection

September 1, 2006 (Vol. 26, No. 15)
ChemDiv's Collaborative CRO Relationships
Current New Drug Application Requirements
BioMarket Trends
VisualSonics Targets the Preclinical Area
Fluidics for qPCR, Diagnostics & Biodefense
Protein Crystallization in Pharma Research
Elizabeth Lipp
Diagnostics in Gene and Protein Expression
Reconfiguring Mass Spec Instrumentation
Myriad Options for Molecular Diagnostics
Gail Dutton
Post-Translational Modification Approaches
ISPE's Role in Pharma Industry's Transition
Process Monitoring On-Line & in Real-Time
Angelo DePalma, Ph.D.
Chinese Biogenerics and Protection of IP
Bringing Drugs and Devices Together
Susan Aldridge, Ph.D.
The Bioethics of IVD Devices and Informed Consent Issues
Automation of Protein Crystallography
Physiologically Relevant HTS Technologies
IntegratedProcess Design & Development
Novel Diagnostics Help Target Therapies

August 1, 2006 (Vol. 26, No. 14)
TechNote: Ca2+ Signal Detection in HTS Operations
Biomarker Discovery and Identification
Whither Steel & Glass in a Disposable Age
TechNote: Antibiotic-Free Systems for Production
Case Study: Vaccine Production Facility Built in 11 Months
Biopharmaceutical Approvals Review
GEN Innovations in Biotechnology
Company Update: Biofocus Expands its Menu of Offerings
Sophia Fox
Role of Cell-Based Assays in R&D Grows
Elizabeth Lipp
Drug Discovery: Successful Lead Optimization Strategies
Kathy Liszewski
Multidimensional Analysis Approaches
Gail Dutton
Overcoming the Critical Issues in Scale-Up
Susan Aldridge, Ph.D.
Development & Production of Antibodies
BioMarket Trends
Facilitating the Manufacturing of Oligos
Carol Potera
Monoclonal Antibody Purification with CHT
Versatile Tag for Cell-Based Screening
Novel Technique for Biomarker Discovery
German Biotechs Embrace Reverse Mergers

July 1, 2006 (Vol. 26, No. 13)
Using Biotech Tools for Plant Breeding
BioMarket Trends
Targeting Biotech Institutional Investors
Epitope Tagging Generates New Products
Protein Kinases in Signal Transduction
Range of Applications for Biomagnetics
Gail Dutton
Market Growing for Custom-Made Peptides
Antiviral Research Hits Its Stride
Elizabeth Lipp
CROs Become a Biotech Industry Staple
Susan Aldridge, Ph.D.
Spotlighting Neurobiotech Developments
Combating the R&D Productivity Decline
Disclosure Issues for Life Sciences Firms
Metrics for Economic Development
Getting More Value from Bioinformatics
Barcoding and Automated Electophoresis
New Tools Improve Bioprocess Operations
Pre-Deal Leadership Due Diligence a Must

June 15, 2006 (Vol. 26, No. 12)
Pain Therapeutics Takes Different Path
Biomarket Trends
Nucleic Acid-Based Technologies Ramp Up
Going a Label-Free Route with Biosensors
Enabling Technologies at MipTec 2006
Susan Aldridge, Ph.D.
Focus on Mid-Densities Drives Multiplex Arrays
Gail Dutton
Biomanufacturing for Regenerative Medicine
Kathy Liszewski
Disposable Bioreactors Gaining Favor
Progress Report on the NIH Roadmap Initiative
Scientific Interactions Advancing in Mid-East
Gilead Targets HIV & Bird Flu Markets
Querida Anderson
ID and Validation of Biomarkers
Cell Density and Physiology Monitoring
Assay: Parallel Approaches to Target Identification
Proteome Partitioning and Fractionation

June 1, 2006 (Vol. 26, No. 11)
Thermogenesis' Art of Cryopreservation
Kate Marusina, Ph.D.
GEN's Annual Top 20 Molecular Millionaires
Governor Says Puerto Rico Will Not Rest on Pharmaceutical Manufacturing Laurels
Chromatography Advances Drug Discovery
Trends & Expectations in Bioinformatics
Target Screening Focuses on Ion Channels
Elizabeth Lipp
SNP Genotyping Methods Surge Ahead
Maintaining Biocontamination Control
Angelo DePalma, Ph.D.
Pharmaceutical Tech Transfer in the Spotlight
Susan Aldridge, Ph.D.
Biofirms Develop Novel Therapeutics for MS
When is Private Really Public?
Marijuana, Medicine & the FDA
Protein Tomography Applications Expand
Assay Tutorial: Adenoviral Vector Gene Delivery System
Microbial and Cell Growth in Microtiter Plates
Reverse Mergers in Life Science Financing

May 15, 2006 (Vol. 26, No. 10)
eGene Transforms Genetic Analysis Field
Deviation Controls in Pharmaceutical R&D
Sample Prep Upstream of Mass Spectrometry
Vicki Glaser
Inhibiting Protein-Protein Interactions
Nonviral Approaches to DNA Delivery
Kathy Liszewski
Targeting a Multibillion-Dollar Market
Querida Anderson
Are We Being Outdone by Bacteria?
Using Isothermal Titration Calorimetry
Assay: Proteomics Technology for Plasma & Serum
Glucose Measurement for Cell Culture

May 1, 2006 (Vol. 26, No. 9)
Source MDx Advances Molecular Medicine
Former President Says Biotech Must Address Energy Needs
Advice on How to Survive the Taq Wars
ADMETox Improves Drug Discovery Rates
Systems-Based Approach Gaining Ground
Angelo DePalma, Ph.D.
Fragment-Based Drug Design Optimizes Hits
Utilizing Metabolic Profiling in Discovery
Pittcon 2006 Launches and Highlights
Surviving the Treacherous Transgenics Path
Navigating the Bench to Bedside Journey
Novel Products for Life Sciences Imaging
Susan Aldridge, Ph.D.
Analysis of a Patent Applicant's Obligations
Nanotechnology in Global Security and Economics
Surface Treatments for Fastidious Cells
Detecting MD-Associated Gene Variants
New Platform for Producing Viral Vaccines
Brave New World of Patents and Pricing

April 15, 2006 (Vol. 26, No. 8)
Chemo-Proteomics Approach to Cancer
Access to Global Networks in Life Sciences
Methods to Develop and Validate Bioassays
Kathy Liszewski
Peptide Drug Discovery Research Reenergized
Achieving Seamless RNA Analysis
Market Increases Oligonucleotide Demands
Microsoft Establishes the BioIT Alliance
Isis Moves Ahead on Antisense Program
Querida Anderson
Bridging Biological Systems Knowledge Gaps
Assay: Microfluidic Capillary Electrophoresis
Glycosylation Patterns During Fermentation

April 1, 2006 (Vol. 26, No. 7)
Genta Seeks Therapeutic Product Approval
Asian Biotech: Taiwan Seeks Successful Business Models
Robert Yuan, Ph.D.
Conference Highlights Drug Delivery Methods
Life Science Cluster Grows in London
Susan Aldridge, Ph.D.
Biotechnology's Mid-Caps Post Solid Gain
Commercial Amounts of Purine Nucleosides
Sophia Fox
Nanobiotech in Genomics and Proteomics
Taming the Genome with Microarrays
Elizabeth Lipp
Protein Characterization Applications Grow
Next-Generation Protein Characterization
Susan Aldridge, Ph.D.
Technical Note: Highly Sensitive qRT-PCR from One Cell
Lean and Six Sigma Approaches Taking Hold
Angelo DePalma, Ph.D.
Characterization of Biologicals Is Advancing
Patent Litigation: Is it Worth the Expense?
Medical Science Liaisons in Biotech
Assay: Protein Production for Structural Analysis
Streamlining Pharmacogenetic Analysis
Thermal Welding for Sterile Connections
Emerging Biopharmaceutical Companies

March 15, 2006 (Vol. 26, No. 6)
The FDA and Follow-On Biologics
Solutions for Cell-Focused Applications
Sophia Fox
Benefits of Structure-Based Drug Design
Assays for Cell Proliferation Studies
Cheminformatics for Finding New Drugs
Elizabeth Lipp
Biomarker Detection & Measurement
Kathy Liszewski
Tissue Microarrays Reach New Markets
CMOs Find Opportunities in Biologics
Multiproduct Manufacturing Facilities
Analyst Likes AEterna Long-Term
Querida Anderson
Implications of Faith-Based Science
Assay: Quantitative Multiplex Immunoassays
Improving Protein Interaction Analysis
Integrating Chirality into Manufacturing

March 1, 2006 (Vol. 26, No. 5)
Finding a Balance in Assessment of Risk
M&As as Important Development Tools
Corporate Profile: Beckman Removes Divisional Barriers
Clearing the Target Validation Bottleneck
In vivo and In vitro Techniques Help to Unclog the Drug Discovery Process
LabAutomation 2006 Final Recap
Protein Arrays as Key Discovery Tools
HPLC Undergoes Slow, Steady Evolution
Angelo DePalma, Ph.D.
QA/QC for Viral Clearance
Gail Dutton
Purification Woes Upstage Upstream Gains
ELN and LIMS Aid Biotechnology Growth
Pitfalls in Patenting of Biomolecules
Good News on Medicines but Bad Rap for Drug Makers
Achieving Low-Volume Liquid Handling
Cell-Based Assays for Study of GPCRs
Choosing & Scaling Up Right Filter Combo
M&As as Important Development Tools

February 15, 2006 (Vol. 26, No. 4)
Tracking Diseases at the Molecular Level
Sophia Fox
Metabolomics Plays Crucial Discovery Role
Kathy Liszewski
In Silico Tools Streamline Drug Design
Gail Dutton
Target Identification Methods Advance
Elizabeth Lipp
Capitalizing on Biotech Production Opportunities
Susan Aldridge, Ph.D.
Ready-to-Play Assays, Kits, and Libraries
Large-Scale Production of Antibodies
CancerVax' Stock Rises with Merger
In Support of Animal Study Management Software
Assay: Miniaturized Cellular Assays
Next-Generation RNA Interference
Optimizing Bacterial Cell Processing

February 1, 2006 (Vol. 26, No. 3)
Biolog Advances Global Cell Analysis Scans
Drug Discovery and Development in India
Extracting Compounds for Diverse Disciplines
Technical Note: Relieving the HTS Bottleneck for Kinases
Optimizing High-Throughput Screening
Improving Gene Expression Analysis
Bright Sky for Single-Use Bioprocess Products
Angelo DePalma, Ph.D.
Scientific Misconduct: Risks to Biotechnology
Wake-up Call for U.S. Innovation
Planning, Documentation, and Collaboration
Multiplex Transcription Factor Profiling
Testing & Validation of Disposable Systems

January 15, 2006 (Vol. 26, No. 2)
New York City Pursues Biotechnology Dream
State of Industry Discussed at BIO-Europe
Susan Aldridge, Ph.D.
Licensing & Collaborations for Tamiflu Patent
Gail Dutton
DeveloGen Tackles Metabolic Disorders
Sophia Fox
Cellular Analysis via High Content Screens
Elizabeth Lipp
Improving Stability While Adding Value
Angelo DePalma, Ph.D.
Development of Stem Cell Technologies
New Biomolecules for Cancer Treatment
French Biotech on the Upturn
Corporate Partnering Status Report
Steps for Preventing the Misuse of Biological Research
Proteomics-Based Biomarker & Drug Discovery
Assay: Protein Microarrays on Nitrocellulose Slides
Embryonic Stem Cell Research Operations

January 1, 2006 (Vol. 26, No. 1)
Biopartnering Crucial to Survival in Europe
Susan Aldridge, Ph.D.
Establishing QC for Molecular Diagnostics
Measurement of a Communications Program
New Tools Highlighted at ASHG Conference
Protein Profiling Poised to Make its Mark
Angelo DePalma, Ph.D.
Correlating Genomics, Race, and Medicine
Gail Dutton
French Biotech Hungers for Fiscal Stimuli
Applying Biomarker Discovery Strategies
RNAi Technologies Become Discovery Staple
Toxicogenomics Enhances Drug Discovery
Kathy Liszewski
Downstream Processing Needs a Boost
Susan Aldridge, Ph.D.
Cell Culture Advances Enable Better Biology
BioMarket Trends: Cell Culture Arena Fueled by Emerging Variety of Biologic Therapeutics
Gene Patents and Global Competition Issues
Policymakers Should Harness User Fees for Drug Safety
Effective GPCR Screening Using ERK 1/2
Maximizing Quality in HTS Kinase Screening
Taking the Guesswork Out of Production

December 1, 2005 (Vol. 25, No. 21)
Mobilizing Nanomedicine Technologies
Industry Analysis of Discovery Informatics
Employment Trends in the Biotech Industry
High Purity Water: Combating Contamination
Gail Dutton
Protein Microarrays
Fluoresence & Bioluminescence Enlighten R&D
Strategies to Move Beyond Target Validation
Biosimilars Shake up the Biologics Market
Taiwan Industry Puts Strong Focus on Biotech
PTO Utility Guidelines Receive Stamp of Approval
Designing an Effective Preclinical Profiling Strategy
Simplified Development of FRET Assays
Using Multi-Pathway Target Knockdown
Parenteral Packaging Concerns for Drugs
Biotech Posts Impressive Third Quarter Results

November 15, 2005 (Vol. 25, No. 20)
The FDA Inspection Process as a Learning Tool
Tissue Models Boost Drug Discovery Efforts
Scotland Pursues Stem Cell Excellence
Chiral Chemistry Aids Drug Development
Gail Dutton
Advancing Viral Vector-Based Technology
Resilience Challenged and in Short Supply in Our Society
Protein Identification and Quantification
Platforms for Eicosanoid Measurements
Optimizing Your Process Unit Operations

November 1, 2005 (Vol. 25, No. 19)
Emerging Technologies for Ion Channels
Challenges Remain for Antibody Products
A New Spin on Plasma Biomarker Discovery
Commercial Bioactivities in Western Canada
Patent Rights and Pharmaceutical Reimportation
Bridging the Gap between Model Systems and Human Biology
Electronic Laboratory Notebook Systems
Purification for Demanding Applications in Life Sciences
The Shrinking Biomanufacturing Facility
How to Improve Series B-Round Valuations

October 15, 2005 (Vol. 25, No. 18)
Review of FDA Guidance on Risk Management
Molecular Diagnostics as Clinical Tools
Gail Dutton
Blue Biotech Puts Norway on the Map
Susan Aldridge, Ph.D.
Whole Genome Amplification Technologies
Mary Addonizio
Novel Systems for Visualizing Biological Data
Kathy Liszewski
Singapore Attracts Life Science Companies
The State of BSE Surveillance Efforts in the United States
Optimized Solutions for RNAi Experiments
Utilizing Rapid Point-of-Use Protein Assays
Recipe for Ensuring Process Control Success
GEN's Spotlight on Wall Street News

October 1, 2005 (Vol. 25, No. 17)
Contract Manufacturing Fills Industry Niche
Linking Discovery Data to Diagnostics
Elizabeth Lipp
GEN Talks with President Bill Clinton
Biotechnology in Australia and New Zealand
Nucleic Acid Purification Takes Many Forms
Ilene Schneider
Manipulation and Analysis of Nucleic Acids
A Step Forward for Biotechnology Patent Law
Proposition for a New and Better Model for Healthcare
Achieving Optimal Yields of High Quality RNA
How do Bacteria Turn Their Genes On and Off?
Nanoscale Gradient Chromatography for LC-MS
Manufacturing of Biopharmaceutical Proteins
Diabetes: Potential Breakthroughs in Therapy

September 15, 2005 (Vol. 25, No. 16)
Applying Mass Spec Tools in Proteomics
Biomolecular Screening Technologies Advance
Flanders' Biotech Sector Comes of Age
Molecular Biology Software Product Update
Kevin Ahern
Microarrays for Model Organism Systems
Patent Law in India Focuses Strongly on R&D
Science and Democracy in Europe and the United States
Novel Tests Based on Genomic Markers
Casting a New Light on GPCR Targets
Lyophilization: Growing with Biotechnology
GEN's Spotlight on Wall Street News

September 1, 2005 (Vol. 25, No. 15)
Preparing for a Potential Pandemic
Gail Dutton
Funding Issues Slow Establishing Biobanks
In Silico Modeling Begins to Produce Results
Gail Dutton
Prion Disease Mechanisms and Activation
Outsourcing Drug Discovery & Development
Whole Genome Sequencing in 24 Hours
Advances in Protein Arrays Overcome Obstacles
Kathy Liszewski
Minnesota Toots Its Own Life Science Horn
The Scylla & Charybdis Face Integrated Genomics
Halting the March of Unreason
High-Sensitivity Mutation Scanning of Tumors
Utilizing a New Tool for Drug Discovery
Enhancing System Cleanliness & Drainability
Biotech and Pharma in a Turbulent World

August 1, 2005 (Vol. 25, No. 14)
Twenty-Five Years of Biotech Trends
Angelo DePalma, Ph.D.
Bioresearch Highlights Significance of SNPs
Drug Delivery Technology: Deals and Advances
Optimizing Strategies for Hit-to-Lead Process
Twists and Turns on the Path to Find New Drugs
North Carolina Leads Southeast in Biotech
Innovative Antibody Products and Therapeutics
Disposable Bioreactors Become Standard Fare
Safe Harbor Provisions for Preclinical Research
Taking a Journey-Based Approach to Manufacturing Development
Automating True Manual Patch Clamping
New Tool for Metabolic Disease Research
Animal-Derived Agents in Disposable Systems
Asia Offers Opportunities in Pharmaceuticals

July 1, 2005 (Vol. 25, No. 13)
Navigating Stem Cell Fact and Fiction
Gail Dutton
Developing Sophisticated Protein-Based Drugs
Tapping the Potential of Protein Drug Discovery
Peptide Manufacturers See Increased Growth
Biomagnetic Separations Move to Next Level
Gail Dutton
Authorized Generics: To Switch Rather than Fight
Evidence-based Medicine
Optimized Chemical Libraries in Drug Discovery
Targeted Disruption Using Group II Introns
High-Yield Single-Use Cell Culture Systems

June 15, 2005 (Vol. 25, No. 12)
FDA Needs to Balance Risks and Benefits for Patients
Applying Nanotech to Materials Research
Gail Dutton
New Biomanufacturing Opportunities & Challenges
Susan Aldridge, Ph.D.
PCR Gains Momentum with New Applications
High Demand for Target Validation Technologies
Using Complexity to Enhance Drug Discovery
Research Options for Structural Proteomics
Gail Dutton
Can India's IT Success be Replicated in Biotech?
Survey of European Scientists on Ethics of Scientific Advancements
Taking Computational Biology to the Bench
Miniaturized Filtration Assay for Discovery
Evaluation of the CellFerm-Pro STBR System

June 1, 2005 (Vol. 25, No. 11)
Optimizing the Drug Target Search
Susan Aldridge, Ph.D.
Greater Philly Region Grows as a Bio Cluster
Functional Genomics Reveals Mysteries of Genes
Ways to Overcome the Small Molecule Curse
Trends in Incubator and Shaker Technologies
Oligo Manufacturing Puts Emphasis on RNA
Mass Spectrometry in the Life Science Market
Examining NIH Policy to Enhance Public Access
Applying PAT to Oligonucleotide Synthesis
Microarray Data Management and Analysis
Integrated Workflow for Development Testing
Anti-Cancer Therapy Success
John F. Wong, Ph.D.

May 15, 2005 (Vol. 25, No. 10)
Regulation of Combination Products by the FDA
Medicinal Chemistry Equals New Leads
Susan Aldridge, Ph.D.
Cutting Through the Biomarker Hype
Elizabeth Lipp
Moving Toward System-Wide Software Suites
Gail Dutton
Signal Pathways Making Inroads in Discovery
Growth of Virginia's Life Science Clusters
Preparation of Clinical Trials Materials

May 1, 2005 (Vol. 25, No. 9)
Making Innovation Work in Drug Discovery
Susan Aldridge, Ph.D.
Creating and Educating a New Biotech Workforce
In Vivo Molecular Imaging Poised for Growth
Biosensors & Biomolecular Interaction Analysis
Expansion of Proteomic Databases Needed
Expansion of Proteomic Databases Needed
Licensing Problems with Diagnostic Genetic Testing
Opportunities and Challenges for Developing Functional Foods
Outsourcing and Globalization in the Industry

April 15, 2005 (Vol. 25, No. 8)
Submitting Pharmacogenomic Data to the FDA
Putting the Squeeze on Manufacturing
Interfering with RNA
NIH Ethics Regulations
Gail Dutton
California Stem Cell Institute Starts Slowly
Microarray Technologies Advancing Medicine
Sample Management and Storage Systems
Turbocharging Expression Microarrays
Establishing a Biotech Industry in Singapore
Robert Yuan, Ph.D.
Biotechnology in Vancouver
Some Activist Groups Exibit a

April 1, 2005 (Vol. 25, No. 7)
Pharma Struggles with Negative Image
Gail Dutton
U.S. HUPO Symposium Focuses on Proteomics
Chemical Genomics Facilitates Finding Targets
Mary Addonizio
Singapore Grooms Firms for Success
Robert Yuan, Ph.D.
Trends in Viral Validation
Gail Dutton
Michigan Life Sciences Industry Extends Roots
Biotechs Focus on Critical Medical Needs
Can a Strong Patent Position Be Illegal?
Reducing Risk with

March 15, 2005 (Vol. 25, No. 6)
FDA Final Current Good Tissue Practice Rule
Screening Technology Challenges
Susan Aldridge, Ph.D.
Using Nanotechnologies In Biotech and Medicine
Lab Automation 101: Effective Integration
The Growing Allure of Rational Drug Design
Kathy Liszewski
Biotech in Wales Quietly Thriving
Sophia Fox
Addressing Stability of Biological Drugs
Misplaced Attacks on the Pharmaceutical Industry

March 1, 2005 (Vol. 25, No. 5)
NIH's New Ethics Regulations
Gail Dutton
Managing Cardiovascular Disease Risk Factors
Phoenix Seeks to Advance its Biotech Initiative
Protein-Protein Interactions in Drug Discovery
The Spotlight Is on Protein-Folding Disorders
Metabonomics Providing Clues to Discovery
Race to Cut Whole Genome Sequencing Costs
Strengthening Pharma and Biotech Patents
Is Biotech in the Midst of a Fifty-Year Cycle?

February 15, 2005 (Vol. 25, No. 4)
FDA's Draft Guidance on Pharmacogenomics
Manufacturing Biologicals Effectively
Personalized Arthritis Therapy
What it Costs fo Operate a Biotech Facility
Staying Up-to-Date in Biomarker Research
Is Biotechnology Complacent to PAT Principles?
Gail Dutton
Conservative Outlook Seen at Investor Forum

February 1, 2005 (Vol. 25, No. 3)
Biobanking Emerging as a Key Growth Area
Susan Aldridge, Ph.D.
Antibody Therapeutics Dominate Meeting
High Throughput Screening of GPCRs
Kathy Liszewski
Advances in Microgenomics: Less is More
Atlanta Bioscience Breaks into the Top Ten
Re-Engineering the Drug Development Pipeline
Mary Addonizio
Could London Become a Major Biotech Hub?
The Impact of Biotech Licensing

January 15, 2005 (Vol. 25, No. 2)
Taking a Look at FDA's Critical Path Initiative
Pharmacogenomic Tests for Breast Cancer
Gail Dutton
BIO-Europe Conference Gauges Future
Susan Aldridge, Ph.D.
High Content Screening Management Options
Microfluidics Technology Goes Mainstream
Panning for Drug Discovery Gold with New Tools
Agilent Advances Lab-on-a-Chip Technique
Susan Aldridge, Ph.D.
Building Momentum in Scandinavian Cluster
The Human Side of Science

January 1, 2005 (Vol. 25, No. 1)
Vioxx and Celebrex Bring Heat to the FDA
Gail Dutton
U.K. to Push Bioprocessing to Forefront
Susan Aldridge, Ph.D.
Obtaining High-Quality Protein Crystals
Druggability: Prime Real Estate of the Genome
Exploiting Post-Translational Modifications
Kathy Liszewski
Progress in Vaccine and Gene Therapy Strategies
Legal Uses of a Patented Invention in the U.S.
Drug Importation Equals Bad Public and Economic Policy
Clinical Data at ASH Boon to Wall St. Analysis

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