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June 15, Vol. 28, No. 12

  • Feature Articles

    • Optimizing Utilization of Biomarkers
    • Kathy Liszewski
    • Biomarker discovery has exploded in the last decade, yet researchers often struggle to validate their biomarkers for widespread clinical use Several recent meetings including CHI’s “Molecular Medicine Tri-Conference” and “Biomarker World Congress” as well as SMi’s “Biomarker Summit” highlighted current ... more »
    • Flexibility Is the Name of the Game for CROs
    • Lloyd Dunlap
    • As the recent “2008 Biopharma Outsourcing” conference sponsored by iiBIG underscored, the term contract research organization (CRO) can take on a wide variety of meanings depending on the specific company it’s applied to As the conference also reinforced, though, there ... more »
    • Overcoming Complications in Multiplexing
    • Catherine Shaffer
    • As a new generation of biodetection assays come of age, we increasingly see implementation of multiple, simultaneous assays In some cases, this multiplexity is modest and pragmatic—just a few assays at a time for very specific purposes In others, ambitious ... more »
    • Finding Balance in Cell-Line Development
    • Angelo DePalma, Ph.D.
    • Cell-line optimization has become a critical step for generating the robust, highly productive cells used in biomanufacturing, cell-based assays, and reagent production While numerous techniques exist for incorporating desirable traits into mammalian cell lines as well as into yeast, bacteria, ... more »
    • Methods for Maximizing Antibody Yields
    • K. John Morrow Jr.
    • Among recombinant proteins, antibodies stand out as the strongest candidates for new therapeutic drugs and represent the majority of submissions to the FDA and other regulatory agencies Total sales of recombinant antibodies reached $158 billion in 2006 and are projected ... more »
    • Managing Asthma and COPD Treatments
    • Sue Pearson, Ph.D.
    • Asthma and chronic obstructive pulmonary disease (COPD) are becoming more common throughout the world especially in countries such as India and China So the potential for treating these diseases is enormous, said Peter Barnes, head of respiratory medicine, Imperial College, ... more »
    • TechUpdate: Are Lentiviral Vectors on Cusp of Br...
    • Tim Ravenscroft
    • Whether it’s vaccines, protein production, or biotherapeutics, lentiviral vectors are increasingly being recognized for their central role as an enabling technology The ability of lentiviral vectors to stably and efficiently deliver heterologous genes into mammalian cells opens a new gateway ... more »
    • Turning Research into Viable Cancer Drugs
    • John Wong
    • The “Annual Meeting for the American Association for Cancer Research (AACR)” is widely viewed by scientists as the main forum to present and discuss cancer-related research In the past, most of the symposia and sessions at this meeting have focused ... more »