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March 1, Vol. 28, No. 5

  • Feature Articles

    • Tapping miRNA-Regulated Pathways
    • Vicki Glaser
    • miRNAs are master regulators of gene expression, according to William S Marshall, PhD, president and CEO of miRagen Therapeutics “You can have one microRNA that controls multiple genes and one gene that is controlled by multiple microRNAs” They exert negative ... more »
    • Small Biotechnology Firms Reach Out to CROs for ...
    • Nina Flanagan
    • Clinical research organizations (CROs) may prove to be a lifeline for biopharmaceutical companies to bring new therapeutics to market faster, cheaper, and without affecting quality Several factors are driving the increasing demand for outsourcing, such as frozen headcounts at pharmaceutical ... more »
    • Oulu Region Lures Biotechnology Firms
    • Susan Aldridge, Ph.D.
    • It is not surprising that Oulu, Finland, a global center for wireless technology, has a vision of bringing biotech, information and communications technologies, as well as nanotech together The Oulu region, however, is also strong in more traditional biotech areas ... more »
    • Pharmaceutical Manufacturing Goes Green
    • Vicki Glaser
    • The EPA’s Presidential Green Chemistry Challenge award was given to Merck in 2006 for developing a green catalytic synthesis route for beta-amino acids The EPA’s challenge award is just one example of a number of initiatives, award programs, and incentives ... more »
    • Innovations Mark Biosensor Development
    • K. John Morrow Jr.
    • Detection and analysis of the structure and function of biomolecules is an essential step in the development of new pharmaceutical products and their application to disease conditions Pharmacology and molecular biology research have been dramatically affected in recent years as ... more »
    • Next-Generation Sequencing Picks Up Pace
    • Lloyd Dunlap
    • When Leonard Bloksberg, PhD, was a research biologist in New Zealand, his large genomic searches using a DEC Alpha Cluster and BLAST were estimated to take years As Dr Bloksberg observed during Cambridge Healthtech’s“Next-Generation Sequencing” (NGS) conference, held late last ... more »
    • Diagnostics Advancing Healthcare Reform
    • John Wong
    • With the presidential elections around the corner, healthcare reform was a hot topic at the “JP Morgan 26th Annual Healthcare Conference,” held in January For biotech executives, it was music to their ears to hear presidential candidates speak about their ... more »
  • Tutorials

    • Development of a Real-Time Immunoassay
    • Jean-Francois Houle
      Paul Smith
    • Thorough elucidation of biomolecular interactions is central to understanding biology and disease mechanisms and subsequently devising safe and effective drugs Life scientists working in academic, pharma, and biotech organizations seek to better understand interactions between protein targets and other proteins ... more »
    • Stabilizing Protein-Folding Conformations
    • Gene Lee
    • Expression of cytokines or growth factors and their subsequent binding to cell surface receptors in healthy individuals is a tightly regulated and coordinated process The inappropriate expression of these circulating proteins can contribute to the onset or progression of a ... more »