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August 1, Vol. 27, No. 14

  • Feature Articles

    • Using AMDE Data to Cut Drug Toxicology Failures
    • Gail Dutton
    • Getting human ADME/Tox data at the early stages of drug development could have substantial payoffs in terms of lowering lead candidates’ toxicology Developing in vitro screening using human cells to counteract this was the focus of the recent “10th International ... more »
    • Cell-Based Research Gains Momentum
    • Elizabeth Lipp
    • Cell-based assays have become the rage once again, and there are a number of avenues for researchers to utilize to get the work they need done At Cambridge Healthtech’s “World Pharmaceutical Congress,” the focus was on new and improved technologies ... more »
    • Effective Optimization: Fight or Flight?
    • Lloyd Dunlap
    • Cambridge Healthtech Institute’s sixth annual “World Pharmaceutical Congress” focused on lead optimization with the goal of increasing the efficiency of the hit-to-lead-to-drug candidate process A roundtable discussion moderated by Christopher B Cooper, PhD, associate director of early discovery chemistry at ... more »
    • Biomarkers Transform R&D
    • Kate Marusina, Ph.D.
    • FDA defines a biomarker as a characteristic “objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to therapeutic intervention” FDA guidance further defines possible, probable, and known biomarker categories depending on the available ... more »
    • Improving Protein Production Processes
    • K. John Morrow Jr.
    • Mammalian cell culture is and will remain the principle vehicle for protein production in upstream manufacturing, according to Florian Wurm, PhD, professor of biochemistry at the University of Lausanne and founder of ExcellGene (wwwexcellgenecom) Dr Wurm reported that 70% of ... more »
    • Nurturing Growth of mAb Therapeutics
    • Catherine Shaffer
    • Explosive growth in the area of therapeutic antibodies in recent years has stimulated new demand for improved production and manufacturing techniques Traditionally, antibodies are produced in mammalian cells, a time- and labor-intensive process This step immediately opens into a true ... more »
    • Demand Strong for Upstream Systems
    • Vicki Glaser
    • The bioreactor market “has been and continues to be very robust, and demand is certainly up,” says Paul Kubera, vp of engineering at ABEC (wwwabeccom, who, together with Mark Herr, sales manager at Stainless Technology (wwwstainlesstechnologycom), a division of ABEC, ... more »
    • Trends in Mass Spec: Roundtable Discussion on MS...
    • Scientists rely on mass spectrometry to identify DNA, RNA, proteins, and naturally occurring metabolites In proteomics research, mass spec is used to characterize proteins, identify single proteins in a mixture, and quantify cellular or oganismal proteins... more »
    • Quest Continues for Innovations in HPLC
    • Susan Aldridge, Ph.D.
    • HPLC is a well-established separation technology that continues to evolve to meet the identification and purification challenges posed by pharma, biotech, and other life science applications Some of the latest techniques and applications were discussed at “HPLC 2007,” held recently ... more »
  • Columns

    • Thermo Fisher Targets Lab Solutions
    • Carol Potera
    • The former Thermo Electron was never shy about acquiring companies George Hatsopoulos founded the company in 1956 and then bought another approximately 80 companies to produce analytical laboratory instruments and biomedical research products Marijn E Dekkers, PhD, who became president ... more »
    • War on Cancer Is Being Oversold
    • Ralph Moss
    • The number of cancer deaths in the US declined by one-half of one percent between 2003 and 2004—and the world went wild Soon after the announcement, on January 17, President Bush paid a rare visit to the NIH to bask ... more »