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February 15, Vol. 27, No. 4

  • Feature Articles

    • Role Grows for HPLC in Discovery
    • Kathy Liszewski
    • High-pressure liquid chromatography (HPLC) remains an important workhorse in drug discovery Continuing upgrades and enhancements to the technology are paving the way to save time and money, improve speed and sensitivity, and to more accurately detect metabolites implicated in toxicity... more »
    • BioMarket Trends: Diagnostic Tools Change Cancer...
    • Harry Glorikian
    • One of the greatest challenges facing clinicians in treating cancer is early diagnosis when there is sufficient time to utilize multiple treatment algorithms Current diagnostic tools, which include various blood marker-based immuonoassays, imaging techniques, and biopsy analysis, provide valuable information ... more »
    • Label-Free Biosensors Show Early Promise
    • K. John Morrow Jr.
    • For the last three decades the predominant means of detecting and measuring antigen-antibody interactions, for research or clinical purposes, has been the ELISA method While simple, cheap, and relatively specific and sensitive, its hegemony is now threatened by a variety ... more »
    • New Methods Get SNPs Closer to Clinic
    • Trevor Stokes
    • In 1998, the first international meeting on SNPs and complex genome analysis was held in Sweden Since then, SNP technology has become more widely adopted Clinical expectations remain high for diagnostic and pharmacogenomic uses of SNPs, and researchers are currently ... more »
    • Regulation Shifts from Product to Process
    • Vicki Glaser
    • However innovative or compelling a novel manufacturing process may be, its value depends on the ability to validate the process and demonstrate its robustness and reproducibility over time Process validation—both the concept and its implementation—is in the midst of undergoing ... more »
    • Optimizing Antibody Biomanufacture
    • K. John Morrow Jr.
    • The low-hanging fruit is long gone from the bioprocessing tree and even the horse chestnuts in the upper branches are harder to reach When biotech companies meet in Carlsbad, CA, for the IBC Life Sciences' “Antibody Production and Development” conference ... more »
    • Techniques for Cell Culture Improvement
    • Susan Aldridge, Ph.D.
    • Cell line development, animal-free media, disposables, and the implications of process change were among the issues discussed at SAFC Biosciences’ (wwwsafcbiosciencescom) “Modern Aspects of Cell Culture and Bioproduction” seminars held in Cambridge and Edinburgh, UK, recently... more »
    • Laboratory Asset Management Is Thriving
    • Gail Dutton
    • Are lab asset management services worth their salt? Millennium Pharmaceuticals (wwwmlnmcom) thinks so A two-year relationship with Thermo Fisher Scientific (wwwthermocom) has trimmed its annual multimillion-dollar maintenance budget by 15–20% compared to what it would have paid the original equipment ... more »
  • Columns

    • Building a Bioscience Cluster
    • Bill Fair
    • Communities across the country are trying to recreate the success of bioscience clusters in Cambridge, LaJolla, Research Triangle Park, and the San Francisco Bay Area The latest Battelle Report highlights 42 states actively looking to attract bioscience investment with an ... more »
  • Tutorials

    • Assay: Perfect Match Versus Single-Base Mismatch
    • Ramin Saberi
    • MicroRNAs are a class of noncoding regulatory RNA molecules that affect gene expression by binding to 3´-untranslated regions of messenger RNAs (mRNAs) Although recently identified as a new class of molecules, initial studies indicate that microRNAs may regulate a significant ... more »
    • Base-Tolerant Affinity Resin for Mabs
    • Aman Mottaqui-Tabar
    • Affinity resins based on recombinant protein A ligand are the industry standard for the primary captures in large-scale antibody purification processes Inherent sensitivity of protein-based affinity ligands, such as protein A, to the most commonly employed cleaning in place (CIP) ... more »