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February 1, Vol. 27, No. 3

  • Feature Articles

    • GEN's Annual Wall Street Roundup
    • Last month’s J P Morgan Healthcare Conference in San Francisco was notable in that neither the usual extreme hype over biotech nor any type of excess negativity about the biopharmaceutical industry was evident Rather, a more sober, not somber, business ... more »
    • Techniques to Overcome HTS Bottlenecks
    • Joan Zimmerman
    • Robotics, automation, and fine-tuning of microplate assays have generally smoothened the way for high-throughput screening (HTS) Now the pressure points are building in the validation and assay design areas as well as in secondary screening, squeezing the upstream and downstream ... more »
    • $1,000 Genome Remains the Holiest
    • Kate Marusina, Ph.D.
    • With the advent and development of high-throughput technologies, DNA sequencing takes center stage as a powerful tool in decoding genetic information However, the goal of sequencing many genomes in parallel can only be made by considerable reduction in sequencing costs ... more »
    • Disposables Win Downstream
    • Angelo DePalma, Ph.D.
    • Last year was a banner year for uptake in single-use products in biomanufacturing, but not so much for novel technology “There’s nothing out there that wasn’t, in one form or another, in 2005,” says Vijay Singh, PhD president, Wave Biotech ... more »
    • Improving Protein Production Strategies
    • K. John Morrow Jr.
    • Biotech companies are faced with increasing demands for recombinant proteins, especially antibodies Every point along the way, from production of the protein to the purification of the final product, is under intense scrutiny, since incremental improvements represent large gains in ... more »
    • U.K. Working to Optimize Bioproduction
    • Susan Aldridge, Ph.D.
    • The third “bioProcessUK” conference took place in Edinburgh recently, putting the spotlight on the challenges of manufacturing biopharmaceutical medicines, which now account for 30% of the drug pipeline and 10% of sales bioProcessUK is a government-funded knowledge transfer network that ... more »
    • Diagnosis, Prognosis, and Therapy Selection
    • Elizabeth Lipp
    • Methods of drug discovery and novel therapeutics have evolved greatly over the last decade, paralleled by advances in diagnostic tools Although there are currently multiple methods of diagnosing and staging cancers based on tissue histology, only recently has the idea ... more »
    • Molecular Diagnostics Market Assessment
    • Alfred Doig
    • In vitro molecular diagnostics have established themselves as effective tools for all aspects of disease management, especially in areas of unmet clinical need Such tests have been developed for screening and prognosis as well as for applications, such as determination ... more »
    • Outsourcing Phase IV Pharma Research
    • According to a new report by Cutting Edge Information (wwwcuttingedgeinfocom), 426% of companies that have the internal infrastructure in place to manage Phase IV studies in-house still choose to outsource much of the work associated with their post-marketing studies The ... more »
  • Columns

    • Automated Molecular Diagnostics
    • David Persing
    • The process of culture-based testing for microbes has been in common use for more than a century In recent decades, molecular diagnostic tests have emerged as a more specific, sensitive, and faster alternative In many cases, however, these tests require ... more »
    • National Security and Scientific Research
    • Stephen Goodman
    • Suppose that Genetic Transduction, a fledgling biotechnology company, has been using foreign graduate students to help develop gene transduction techniques, although the company does not yet have a product to sell Further suppose that the company’s president receives a letter ... more »
    • Aldagen Isolates Highly Active Stem Cells
    • Carol Potera
    • Stem cell therapy promises to provide replacement cells to rebuild damaged spinal cords and hearts and solutions to other serious disorders Biotechnology companies are searching for ways to optimize adult stem cells obtained from human bone marrow or blood as ... more »