Leading the Way in Life Science Technologies

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December 1, Vol. 26, No. 21

  • Feature Articles

    • BioMarket Trends
    • The life science tools industry consists of a broad range of companies providing technology solutions that form the basis for drug discovery, applied market testing (eg, bio-defense, environmental, food, forensics, etc), and basic scientific and medical research Our knowledge of ... more »
    • Finding and Working with a Staffing Firm
    • Over the last decade, biotechnology companies have gained visibility as the investment community views the high potential return afforded by the expensive drugs they produce With investors pumping so much money into research, biotech companies are racing to get their ... more »
    • Lab Notebooks Offer Efficiency Gains
    • Gail Dutton
    • Laboratory notebooks contain a literal wealth of information to advance research enterprise-wide, to protect and support patents, and to streamline the regulatory submissions process—if only they could be easily accessed For most companies, the kernels of insights contained in those ... more »
    • Honing in on signal Transduction Pathways
    • Signal transduction is a key mechanism that brings about several physiological responses in a cell Aberrant signaling can result due to gene mutations or regulatory protein overexpression It is presumed that about 400 human diseases are due to signal transduction ... more »
    • Gauging Nanobiotech's Promise Realistically
    • Biotech products based on nanotechnology are becoming more widespread, but not without first encountering substantial challenges According to a report issued by the ETC Group (wwwetcgrouporg/en), the major pharmaceutical companies generally have been taking a wait-and-see attitude on nanotechnology... more »
    • Collaborative Spirit Fosters Bioinformatics
    • Strategically located between the University of North Carolina at Chapel Hill, North Carolina State University, and Duke University, Research Triangle Park (RTP) has been a cornerstone of the biotechnology industry since its earliest days More recently, advancements in biotechnology have ... more »
    • Minimizing Cost and Use of Purified Water
    • The pharmaceutical industry is facing strong and growing pressure to reduce the cost of producing drugs One universal way to do that is to cut operating expenses, lowering the day-to-day costs of doing business Minimizing energy and utility usage can ... more »
    • Marine Bioprospecting for Novel Drugs
    • Susan Aldridge, Ph.D.
    • Natural products have long been a major source of medicines In recent years, however, they’ve had to compete with synthetic chemicals, especially those from combinatorial chemistry It has been suggested, though, that dropping natural-product programs has contributed to big pharma’s ... more »
  • Columns

    • Market Research Tips for Suppliers
    • In the current life science business environment, new product development is swift, competition is fierce, and the marketplace is fragmented with multiple distribution channels There is less room than ever for missteps... more »
    • Abbreviated Approval of Generic Biologics
    • The creation of an abbreviated approval pathway for generic biologics, like that existing for the approval of generic versions of traditional drugs, is at long last the subject of pending legislation—Rep Henry Waxman’s recently proposed Access to Life-Saving Medicine Act ... more »
    • Recent Growth Sets Stage for Q4 2006
    • After biotech enjoyed its best quarter of the year, the Burrill Biotech Select Index recovered most of its value lost in the first two quarters and finished down just 9% from its 3Q 2005 value Heading into the final quarter, ... more »
    • Bioanalytical Systems Targets CRO Niche
    • Peter Kissinger, PhD, started Bioanalytical Systems (BASi; wwwbioanalyticalcom) 32 years ago in his garage with just $365 He tinkered on his inventions in his spare time, as all researchers had to do before SBIR grants... more »
  • Tutorials

    • Finding Modulators of the Hh Pathway
    • It has been noted that there are several features shared between stem and tumor cells, including self-renewal and replication potential It is believed that the early stage of oncogenesis involves acquisition of mutations in a single cell accumulated during its ... more »
    • Systems Biology Tools Get Personal
    • Over the last few years, we have witnessed the rapid evolution of software tools for functional analysis of microarray gene expression, proteomics, metabolomics and other omics data Integrated data-mining platforms, such as MetaCore and MetaDrug ( GeneGo ; wwwgenegocom), combine ... more »
    • Basic Considerations for Laboratory Water
    • Water is probably the most commonly used laboratory reagent However, it is often taken for granted and its potential impact on experimental outcomes overlooked Understanding basic principles regarding laboratory water may help scientists avoid common pitfalls Millipore (wwwmilliporecom) has extensive ... more »