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November 15, Vol. 26, No. 20

  • Feature Articles

    • BioTime Bets on Blood Replacement
    • Gail Dutton
    • When a US soldier is wounded in combat, his lost blood is often replaced with Hextend®, a plasma expander developed by BioTime (wwwbiotimeinccom) The high molecular weight plasma expander also is being used in high blood loss surgery at hospitals ... more »
    • TechNote: High-Throughput DNA Extraction Solutio...
    • Most procedures for extracting DNA from general substrates involve manipulations that reduce yields and expose the sample to potential contamination Additionally, most methods also require centrifugation, vacuum, or solvent extraction—steps that render them difficult for automation... more »
    • Optimizing the Value of Potential Novel Drugs
    • Maximizing compound value to ensure successful downstream discovery operations was the theme of the second “Compound Management, Integrity, and QC Summit,” organized by the International Quality and Productivity Center, held recently in Philadelphia... more »
    • Sample Prep Gaining Priority in Discovery
    • Nina Flanagan
    • The myriad of challenges of sample prep are being addressed in unique ways by many companies These range from platform technologies, purification kits, automation, methods to stabilize samples, to validation approaches The bottom line is that assay results are robust ... more »
    • The Next Generation of DNA Sequencing
    • Kate Marusina, Ph.D.
    • Over the past decade, DNA sequencing throughput has increased over 50-fold Advances in DNA sequencing have enabled logarithmic growth of data points and breadth in coverage of an individual genome High-throughput sequencing holds great promise for population-wide analysis that may ... more »
    • Filtration Technology Steps Up to Next Level
    • Process streams look very different from five or ten years ago, states Jean Paul Mangeolle, president of Millipore’s (wwwmilliporecom) bioprocess division Rising protein titers have caused many processes to shrink, but more concentrated process fluids strain downstream operations designed for ... more »
    • Product Technologies for Lyophilization
    • Freeze-drying or lyophilization is a process that removes water from a substance This dehydration process is performed under vacuum while the substance is in a frozen state Lyophilization technology is used to freeze-dry products such as biologicals, bacterial cultures, analytical ... more »
    • China-Grown Pharma Products
    • With a staggering 25% annual domestic biopharmaceutical sales revenue growth over the past four to five years, China is projected to become one of the world’s major biopharmaceutical markets within the next two decades Much of this growth is attributed ... more »
  • Columns

    • Who Will Lead the Revolution?
    • Human genetics has experienced two revolutions One was the recognition that much of human health and disease has a genetic basis The second revolution, which came through the efforts to map and sequence the human and other genomes, was the ... more »
  • Tutorials

    • Consistency from a Small Integrated System
    • The rapid and effective preparation of biomolecules is a required first step in many common laboratory preparative and analytical techniques The use of varying degrees of automation can provide advantages by offering consistency beyond the capabilities of manual preparative methods ... more »
    • Biospecimen Collection and Management
    • Today’s drug discovery and development is critically dependent on biospecimens In development of a drug or new procedure, a company may collect hundreds of thousands of these specimens from both humans and animals, beginning with basic research and continuing all ... more »
    • Genomic-Proteomic Cell Culture Approaches
    • Production of recombinant therapeutic proteins in mammalian cells represents a significant segment of the pharmaceutical market, and therefore striving for increased productivity of these lines represents a major investment of resources... more »