Leading the Way in Life Science Technologies

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October 1, Vol. 26, No. 17

  • Feature Articles

    • BioMarket Trends
    • The value of the primary and secondary US biomanufacturing market in 2006 is estimated to be approximately $50 billion with a healthy growth rate almost approaching double digits due to the escalating number of biotech drugs in the pipeline and ... more »
    • Inflammation Research Leads to Targets
    • Late last month, GlaxoSmithKline (GSK; wwwgskcom) and ChemoCentryx (wwwchemocentryxcom) signed a multitarget strategic alliance, potentially worth 15 billion, to discover, develop, and market novel medicines targeting four chemokine and chemoattractant receptors for the treatment of a variety of inflammatory disorders... more »
    • Expanding Applications of Diagnostic Tools
    • As many as one in 10 adults worldwide develops a thyroid nodule that requires clinical investigation The incidence of thyroid cancer is rapidly increasing, particularly among women, and although the majority of thyroid nodules are benign, each one must be ... more »
    • Changing the Way Research Is Conducted
    • For the last half century, biological researchers have looked at one gene and its related protein in isolation from others Although the take-home message from this approach is that biology and medicine are complex, “we still don't understand deep principles,” ... more »
    • PCR Applications Continue to Expand
    • Elizabeth Lipp
    • Although PCR technology is nearly a quarter of a century old, scientists not only use it but depend on it, particularly in the areas of gene expression and microarray processes Researchers discussed the latest advances in PCR at Cambridge Healthtech’s ... more »
    • New Software Tackles Mounds of Data
    • Rapid advances in life sciences technology have provided researchers with vast amounts of data Now, the challenge is to analyze and visualize the data to increase its accessibility Many companies are meeting this challenge with new software solutions... more »
    • Bringing Pharmacogenomics into the Clinic
    • Biomarkers are capable of bridging the distance between basic research and late-stage clinical trials and can even shorten it Many pharmaceutical and biotech companies are investing additional resources to bring biomarkers into the clinic They hope that these efforts to ... more »
    • Monoliths Seen to Revitalize Bioseparations
    • The early 1980s marked a major renaissance for chromatography An unprecedented diversity of new analytical and preparative products was introduced within an exciting period of a few years, creating the foundation for the products currently serving the industry... more »
    • TechNote: Ratiometric Photometry for Calibration
    • For Linco Diagnostic Services (wwwlincodiagnosticscom), quality assurance is critical Performing functions such as bioanalytical services and clinical trials for pharmaceutical and biotechnology companies, Linco is under intense scrutiny by its clients, as well as the FDA Given the integral role ... more »
  • Columns

    • New Gene Sequencer Targets Productivity
    • Solexa (wwwsolexacom) claims that its new technology will transform sequencing by reducing cost and increasing throughput “Our technology will offer a hundred-fold improvement in productivity and a hundred-fold reduction in cost, a combination that no other sequencing platform has ... more »
    • Life Sciences Strategic Deal-Making Trends
    • The life sciences sector during 2005 was characterized by tight capital markets, increasing regulatory hurdles, and a dramatic increase in capital raised through strategic partnering During the first half of 2006, those trends continued to have a significant impact on ... more »
    • Patent Rights in Biological Material
    • In the late 1970s, John Moore sought treatment for hairy-cell leukemia at UCLA Medical Center During his treatment, his attending physician, David Golde, MD, took samples of blood, bone marrow, and other tissue from Moore Upon Dr Golde’s recommendation, Moore ... more »
    • Making the Complex Simple
    • Biotechnology is coming of age There are well over 200 medicines and related products created from biotech techniques currently available, and FDA approval of biotech drugs is expected to outpace pharma approvals over the next few years... more »
  • Tutorials

    • Isothermal Titration to Characterize Binding
    • All biochemical reactions involve recognition, binding, and the formation of noncovalent complexes Many small molecule drugs act by selectively binding to protein or nucleic acid targets and altering their binding characteristics Since all binding events are accompanied by the evolution ... more »
    • Epitope Mapping and Vaccine Research
    • Vaccines have arguably saved more lives than any other medical breakthrough However, despite the long list of diseases that can now be controlled by vaccination, there are still some urgent unmet medical needs, including vaccines for pathogens, such as HIV, ... more »
    • Ensuring Efficient Aeration of Cell Cultures
    • B ioreactor development has progressed signficantly over the last few years However it remains important to stay abreast of additional advances in cell culture research to be able to produce new drugs efficiently Bioengineering’s (wwwbioengineeringcom) new aeration filter system facilitates ... more »