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Sep. 15, Vol. 26, No. 16

    • Columns

      • ExSAR Focuses on Discovery & Optimization
      • The mass spectrometry platform developed by ExSAR (www.exsar.com) reveals the conformational dynamics, or flexibility, of protein structures in solution at high resolution. Because the technology can detect small changes in protein structure, it is ... more »
    • Feature Articles

      • Biomolecular Screening Technologies
      • Biomolecular screening broadly encompasses biological and biochemical screening approaches in the quest to find new drugs. It typically involves the use of cells, chemistry, genomics, and proteomics in one or many aspects of the screening assay. Bio ... more »
      • Bioprocess Simulations Gain Traction
      • Gail Dutton
      • Bioprocessing simulations are gaining traction and sophistication in the biotech industry. Long a standard in other industries, “simulations are becoming requirements for all major design, construction, and de-bottlenecking projects,” according to D ... more »
      • Driving Standards in Single-Use Disposables
      • Sometimes a technology is so obviously the right thing that it is hard to remember what it was like before the technology emerged. Single-use disposables for the bioprocessing industry is one such technology; the bioprocessing industry immediately r ... more »
      • European Biotechs Face a Funding Crisis
      • Over the past four years, European public markets have focused on floating companies with compounds in Phase II or III. Indeed, a large number of venture capital firms will not even go near a biotech company without a Phase II molecule. “This leave ... more »
      • Maximizing Cell-Based Imaging Results
      • In the continuing quest to optimize drug discovery, cells and their interaction with media have become the natural focus of assays that can more accurately predict the behavior of the whole organism in response to an agent. Proteomics and contextual ... more »
      • RNAi in Drug Discovery & Therapeutics
      • Kathy Liszewski
      • The fledgling science of RNAi is making strides to take its place not only as a powerful therapeutic but also as a dynamic tool to increase the speed and efficiency of target validation and drug discovery. New advances will be highlighted at the upc ... more »
      • Slow Adoption of PAT for Bioprocessing
      • Adoption of the FDA’s Process Analytical Technology (PAT) guidance and implementation of PAT throughout the pharma/biotech industry on the small molecule side has been quite good, “but progress in large molecular development has been much slower,” s ... more »
      • Systematic Approach to Optimizing HPLC
      • Gail Dutton
      • How do you choose the best, most efficient HPLC method when outcomes are affected by every variation to the methodology? The answer, according to researchers at the recent “HPLC 2006” conference in San Francisco, is to develop a systematic approach ... more »
    • Tutorials

      • LOH and DNA Copy Number Changes
      • The beginnings of personalized medicine have been forged by recent advances in SNP genotyping technologies. It is now possible to accurately analyze over 600,000 SNPs across large patient sets, enabling powerful whole genome association studies. A n ... more »
      • Minimizing Off-Target Effects in Transfection
      • Transfection is a method used to introduce nucleic acids into mammalian and insect cells. This technique has been used for a wide variety of applications involving protein expression and/or gene analysis. The introduction of a specific gene into cel ... more »
      • Overview of SmartFlow Tangential Flow Filtration
      • Advances in fermentation and cell culture techniques have greatly increased the titers of target proteins in culture fluid. This increase in upstream efficiency has led to a bottleneck in downstream processing at the cell-harvest stage. Scale up of ... more »

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