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September 1, Vol. 26, No. 15

  • Feature Articles

    • BioMarket Trends
    • With over 325 commercial suppliers of antibodies, selecting the right antibody brings to mind the famous lock-and-key analogy of antibody-antigen binding—how do scientists find the perfect match? BioInformatics surveyed 1,000 life scientists about the types of antibodies they use and ... more »
    • Fluidics for qPCR, Diagnostics & Biodefense
    • Micro- and nanofluidics technologies are enabling highly parallel, rapid analytical processes in drug discovery In addition to research applications, microfluidics is playing an increasingly important role in the development of highly sensitive point-of-care diagnostics and in devices designed to detect ... more »
    • Diagnostics in Gene and Protein Expression
    • Molecular diagnostics is a blend of genomics and proteomics tools for studying gene and protein expression It is well established in infectious disease diagnosis but is becoming increasingly important in the context of inherited genetic disorders, drug development, and personalized ... more »
    • Reconfiguring Mass Spec Instrumentation
    • In the past year, various new products designed to make mass spectrometry (MS) faster, as well as more efficient, user-friendly, and practical in a clinical setting have been introduced While the technology has long been in industrial labs, constituting a ... more »
    • Post-Translational Modification Approaches
    • One of the main goals of proteomics is to unravel the many modifications important for biological activity Post-translational modifications (PTMs) extend the range of protein function by attaching it to other biochemical functional groups like phosphates and carbohydrates Many companies ... more »
    • ISPE's Role in Pharma Industry's Transition
    • The pharmaceutical industry is at the beginning of a transition period in which major technological changes may significantly affect the industry, according to Gert Moelgaard, chairman of the International Society for Pharmaceutical Engineers (ISPE) and vp at NNE (wwwnnebizcom) “Looking ... more »
    • Process Monitoring On-Line & in Real-Time
    • Angelo DePalma
    • Bioprocess monitoring is rapidly becoming a tool for achieving process understanding and control and, ultimately, for realizing high yields and quality product Understanding which analytes matter most within a cell culture or fermentation process takes considerable upfront development work A ... more »
    • Chinese Biogenerics and Protection of IP
    • Generic drugs represent one of the greatest values in the world’s healthcare business and are of profound significance in the area of biopharmaceuticals Because biopharmaceuticals are currently among the most expensive therapeutics on the market, and a growing number of ... more »
    • Bringing Drugs and Devices Together
    • Susan Aldridge, Ph.D.
    • Converging medical technologies, which broadly speaking bring drugs and devices together, are becoming so important that the companies involved now need their own forum for discussion and partnering EDB Group responded by recently setting up the first-ever “BioDevice Partnering” event ... more »
  • Columns

    • ChemDiv's Collaborative CRO Relationships
    • Biotechnology and pharmaceutical companies looking to outsource various stages of the drug discovery process can find a range of services at ChemDiv (wwwchemdivcom), based in San Diego and Moscow This contract research organization (CRO) with a 15-year proven track record ... more »
    • Novel Diagnostics Help Target Therapies
    • Diagnostic product revenues with genomics-based technologies are ramping up The growth area in the IVD market for the next five years will be molecular tests for oncology and infectious diseases Also, since industry and doctors have rediscovered the need for ... more »
    • Current New Drug Application Requirements
    • Understanding the requirements behind the FDA’s New Drug Application process can save substantial time in the development of biopharmaceuticals and allow companies in the life sciences sector to appropriately plan strategies that will maximize efficiency, control costs, and engage in ... more »
    • The Bioethics of IVD Devices and Informed Consen...
    • Recently, no area has contributed more and increasingly complex layers to the bioethics debate than research employing human genetic material One such layer involves the use of patient samples for in vitro diagnostic (IVD) device studies and informed consent requirements, ... more »
  • Tutorials

    • Automation of Protein Crystallography
    • Protein crystallography has significantly aided the understanding of human disease at a molecular level As the knowledge of accurate molecular structures is a prerequisite for rational drug design, protein crystallography has also had a substantial impact on the drug discovery ... more »
    • Physiologically Relevant HTS Technologies
    • The R&D productivity gap, or the increasing amount of pharmaceutical R&D spending relative to the number of new drug candidates introduced per year, has been widely discussed in the industry and media Many companies are responding by reexamining the tools, ... more »
    • IntegratedProcess Design & Development
    • Process development and integration of unit operations during the drug development cycle for a typical microbial or mammalian cell culture process is important Most biopharmaceutical companies have their own in-house process development programs In addition, several CMOs are involved in ... more »