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June 1, Vol. 26, No. 11

  • Feature Articles

    • GEN's Annual Top 20 Molecular Millionaires
    • Genetic Engineering News is pleased to present the 2006 version of GEN&#8217s Molecular Millionaires This is our annual listing of doctoral-degree-holding individuals who have made millions through ownership of biotechnology and pharmaceutical stocks You will no doubt notice a change ... more »
    • Chromatography Advances Drug Discovery
    • Companies are addressing requests for higher throughput with higher resolution in chromatography by developing more sophisticated platforms In addition, many are introducing nanoscale instruments for protein separation and addressing niche markets like Mab separation, while others are developing turn-key solutions ... more »
    • Trends & Expectations in Bioinformatics
    • It is now hard to imagine a biological laboratory without bioinformatics tools In the last 10 years, bioinformatics has surpassed its original definition of software technologies aiding in annotation and manipulation of genetic information Today&#8217s bioinformatics is at the intersection ... more »
    • SNP Genotyping Methods Surge Ahead
    • The genetic makeup of a human being is determined by DNA sequences that are made up of four nucleotides, adenine, cytosine, thymine, and guanine, in a multitude of combinations Variations in these DNA sequences can alter the genetic code and ... more »
    • Maintaining Biocontamination Control
    • Angelo DePalma, Ph.D.
    • Common wisdom holds that bacteria and viruses are everywhereexcept, of course, in bioprocesses Keenly aware of this, biomanufacturers have numerous approaches to limiting biocontamination upstream and eliminating it to undetectable levels downstream Processes stay clean mostly by assuring that microbes ... more »
    • Biofirms Develop Novel Therapeutics for MS
    • Acorda Therapeutics (wwwacordacom) recently completed enrollment of its Phase III trial of Fampridine-SR in multiple sclerosis (MS) The study, which is based on a Special Protocol Assessment issued by the FDA, is evaluating the safety and efficacy of Fampridine-SR ... more »
  • Columns

    • Thermogenesis' Art of Cryopreservation
    • Kate Marusina, Ph.D.
    • Despite the publicity around the seemingly unlimited medical promises of embryonic stem (ES) cells, these ideas are still far from being clinically implemented Political wrangling, religious rejections, ethical dilemmas, and technical difficulties mar research on ES cells Meanwhile, their lesser ... more »
    • Reverse Mergers in Life Science Financing
    • Life science companies that have plunged into the IPO waters over the past few years have likely found the temperature, at best, tepid Rather than being warmly embraced by the public markets, as was the case in the not too ... more »
    • Marijuana, Medicine & the FDA
    • On April 20, the FDA jumped into the medical marijuana controversy with a statement that was puzzling on many levels and should leave all Americans concerned about the politicization of the agency we depend on to protect our health... more »
    • When is Private Really Public?
    • Good news for inventors Using an invention secretly in one&#8217s own shop, even for a period longer than a year, will not by itself cause a court to invalidate a patent filed later to protect the invention This rule was ... more »
  • Tutorials

    • Protein Tomography Applications Expand
    • Confidently predicting clinical outcome from research in the discovery phase of drug development remains a major dilemma for pharmaceutical companies The problem is particularly acute in the transfer of studies of human disease from human biology into model systems and ... more »
    • Assay Tutorial: Adenoviral Vector Gene Delivery ...
    • Biological assays in established and primary cells can greatly aid the drug discovery process Stable cell (inheritable genotype) lines are chosen for their consistent profile and efficient measure of compound activity Transient cell-based assays offer greater flexibility with regards to ... more »
    • Microbial and Cell Growth in Microtiter Plates
    • Construct and mutant libraries, as well as collections of bacteria, fungi, and streptomycetes and eukaryotic cell lines are being used in a wide range of research areas As diverse as these areas may beranging from traditional streptomycete screening aimed at ... more »