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May 15, Vol. 26, No. 10

  • Feature Articles

    • Sample Prep Upstream of Mass Spectrometry
    • Vicki Glaser
    • Continuing advances in MS technology are both driving and aiding progress in the development of novel sample-prep methods Advances in MS instrumentation are moving toward higher sensitivity, resolution, and throughput, says John Leite, PhD, mass spectrometry product manager at Invitrogen(wwwinvitrogencom) ... more »
    • Inhibiting Protein-Protein Interactions
    • Recombinant therapeutic proteins are a rapidly growing category of the prescription drug market, with sales projected to reach $50 billion worldwide by 2010, according to BCC Research These products, especially antibodies, tend to be highly specific for their targets and ... more »
    • Nonviral Approaches to DNA Delivery
    • Kathy Liszewski
    • Delivering DNA into cells is a rapidly developing area of biotechnology and gene therapy Additionally, it is a powerful research tool for deciphering gene structure, function, and regulation Nonviral methods for gene delivery center on the use of chemical formulations ... more »
  • Columns

    • eGene Transforms Genetic Analysis Field
    • While working as an applications scientist in the bio-instrument industry, molecular geneticist Ming Liu, PhD, came to appreciate the potential of capillary electrophoresis and decided to develop the technology into a routine tool for the molecular biology laboratory In 2000, ... more »
    • Are We Being Outdone by Bacteria?
    • During the late 1960&#8217s, my college roommate suffered a seemingly minor skin infection on a finger, which quickly turned into blood poisoning and resulted in a hip abscess The infection resolved completely after a few weeks of therapy with a ... more »
    • Deviation Controls in Pharmaceutical R&D
    • The title of this article may surprise some who wonder how deviations can occur in an R&D environment and why there should be controls to prevent them Over the years, various scientists have commented that research is a creative process ... more »
  • Tutorials

    • Using Isothermal Titration Calorimetry
    • Enzymes are important in drug discovery and development since they constitute approximately one-half of all known drug targets Researchers need to understand how enzymes work with natural substrates before they can develop new therapeutic agents Traditional assays use spectrophotometric or ... more »
    • Assay: Proteomics Technology for Plasma & Serum
    • Blood is a rich and readily accessible source for the detection of diagnostic markers and therapeutic targets in many human diseases, such as cardiovascular diseases, neurological disorders, and cancer Currently, however, only a handful of plasma proteins are routinely used ... more »
    • Glucose Measurement for Cell Culture
    • Cell cultures have been widely used to express heterogonous genes and produce therapeutic proteins CHO, HK273, NSO, and Sf9 are some of the most popular cell lines used in cell culture Glucose is the major carbon source in the cultures ... more »