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April 15, Vol. 26, No. 8

  • Feature Articles

    • Access to Global Networks in Life Sciences
    • Networking is vital to biotech because companies can only grow and bring their products to market through developing the right contacts, alliances, and entrepreneurial skills Additionally, as the business goes global, networking skills have never been more important... more »
    • Methods to Develop and Validate Bioassays
    • Kathy Liszewski
    • Developing and validating appropriate biological assays can spell success or failure for biopharmaceutical products Whether using live systems or biologically derived reagents, scientists must carefully design, appropriately use, and exactingly analyze data... more »
    • Peptide Drug Discovery Research Reenergized
    • Fail fast and fail cheap is the current mantra in drug discovery This approach is based on the premise that elimination of high-risk compounds early in the discovery process increases the success rate of finding a new therapeutic drug Also, ... more »
    • Achieving Seamless RNA Analysis
    • Good-quality RNA impacts downstream analysis and results, explains Lucy Sha, marketing director for gene and protein discovery at GE Healthcare (wwwgehealthcarecom) &#8220Sample preparation is critical, and the entire process of RNA analysis should be seamless, without bottlenecks,&#8220 Sha adds... more »
    • Market Increases Oligonucleotide Demands
    • Even as new players join the competitive market for research- and pharmaceutical-grade oligonucleotides, acquisitions and partnerships continue to change the face of the supplier landscape Demand is driven by the established market for primers and probes and the growing market ... more »
    • Microsoft Establishes the BioIT Alliance
    • Microsoft (wwwmicrosoftcom) has formed the BioIT Alliance (wwwbioitallianceorg), a cross-industry group that will focus on further integrating science and technology with the goal of making personalized medicine a reality The alliance brings together companies from the pharmaceutical, biotech, hardware, and ... more »
  • Columns

    • Isis Moves Ahead on Antisense Program
    • Querida Anderson
    • Isis Pharmaceuticals (wwwisispharmcom) has developed an antisense drug candidate that continues to show potential in treating patients with cardiovascular diseases by reducing cholesterol, LDL-C, as well as triglyceride levels Although excitement is over only this one drug, because it is ... more »
    • Chemo-Proteomics Approach to Cancer
    • Many biopharmaceutical companies are seeking new anticancer treatments Serenex (wwwserenexcom) is among them Its lead compound, SNX-1012, is a first-in-class therapy for oral mucositis, the most common debilitating side effect of chemotherapy and radiation treatments for solid tumors SNX-1012 blocks ... more »
  • Tutorials

    • Bridging Biological Systems Knowledge Gaps
    • Knowledge of the molecular processes that constitute biological systems has grown explosively in recent years Translating that knowledge into useful therapies, however, has fallen short of early expectations Translational researchers confront a stubborn, multidimensional gap in which technological deficiencies along ... more »
    • Assay: Microfluidic Capillary Electrophoresis
    • With the recent advances in genomics, combinatorial chemistry, and automation, drug discovery scientists working in pharmaceutical, biotechnology, and academic environments are faced with the overwhelming task of developing many new assays These assays must be robust, rapid, economical, miniaturized, automated, ... more »
    • Glycosylation Patterns During Fermentation
    • Glycosylation is one of the most abundant of all protein post-translational modifications (PTMs) It results from the addition of sugar residues to protein sidechains to form a glycoprotein Mammalian glycoprotein oligosaccharides are commonly built from a limited number of monosaccharides ... more »