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Apr. 1, Vol. 26, No. 7

    • Columns

      • Emerging Biopharmaceutical Companies
      • The 2005 bull market in biotechnology stocks continued to run through the end of February. Biotech stocks tend to do well in the November&#8211February time frame, and 2006 has great momentum so far. Driving this strength are a number of fundame ... more »
      • Genta Seeks Therapeutic Product Approval
      • Ten years after starting the first human trials of its lead anticancer drug Genasense (oblimersen sodium injection), Genta (www.genta.com) is seeking marketing approval for the treatment of patients with relapsed or refractory chronic lymphocytic le ... more »
      • Medical Science Liaisons in Biotech
      • Last December, an article in this publication listed medical science liaisons (MSLs) among the hot jobs in biotechnology&#8217s transition from R&D-focused activity to commercialization (see Employment Trends in the Biotech Industry, GEN, De ... more »
      • Patent Litigation: Is it Worth the Expense?
      • Tech-savvy companies know that successful enforcement of intellectual property rights and, particularly, patent rights can offer substantial rewards. In the U.S. patents represent a constitutionally granted monopoly to exclude others from using an i ... more »
      • Biotechnology's Mid-Caps Post Solid Gain
      • In the relatively quiet month of February, the biotech industry managed to outperform the markets with the Burrill Biotech Select Index up 4.5%, while the NASDAQ finished down 1% and the Dow up 1%. In addition, the biotech industry reached a signifi ... more »
      • Characterization of Biologicals Is Advancing
      • The concept of well-characterized biologicals originated with the FDA Center for Biologics Evaluation and Research (CBER), which first employed the term in 1996. Prior to 1996, CBER required both a Product License Agreement (PLA) and an Establishmen ... more »
      • Commercial Amounts of Purine Nucleosides
      • Sophia Fox
      • Metkinen Chemistry (www.metkinenchemistry.com) recently unveiled a biotransformation technology that, the company says, has enabled for the first time the cost-effective commercial production of purine nucleoside analogues for use in the development ... more »
      • Conference Highlights Drug Delivery Methods
      • Novel strategies for drug delivery, as well as new twists on old approaches were among the topics of discussion at the annual Roth Capital Partners Conference, recently held in Dana Point, CA. Citing drivers such as bioterrorism, natural disasters, ... more »
      • Nanobiotech in Genomics and Proteomics
      • Nanotechnology is the creation and utilization of materials, devices, and systems through the control of matter on the nanometer-length scale, i.e., at the level of atoms, molecules, and supramolecular structures. It is the popular term for the cons ... more »
      • Protein Characterization Applications Grow
      • As the demands for more detailed protein characterization increase, many companies are working to meet those demands through new tools, technologies, and assays. Alistair Kippen, Ph.D., head of protein analysis at Covance (www.covance.com), says th ... more »
      • Taming the Genome with Microarrays
      • Elizabeth Lipp
      • When scientists finished mapping the human genome, they thought their work was done. However, they have since found out that there is such a thing as too much information. There are only a little more than a handful of companies that are pioneering ... more »
      • Technical Note: Highly Sensitive qRT-PCR from One Cell
      • Ideally, gene expression studies by quantitative RT-PCR (qRT-PCR) should be performed using RNA from homogeneous cell populations. Frequently, this means performing qRT-PCR using picogram amounts of total cellular RNA and, in some instances, using t ... more »
    • Tutorials

      • Assay: Protein Production for Structural Analysis
      • Elucidation of protein structure and function maintains an important role in post-genomic sequencing and analysis studies. An efficient protein production system is critical for obtaining large amounts of correctly folded recombinant protein for stu ... more »
      • Streamlining Pharmacogenetic Analysis
      • The National Center for Biotechnology Information determined that in 1994 there were over 2.2 million cases of adverse drug reactions in the U.S. Adverse drug reactions, which are rooted in individuals&#8217 variable responses to medication, are ... more »
      • Thermal Welding for Sterile Connections
      • Disposable process equipment demands reliable and fast sterile connecting devices. Two of the important issues in disposable manufacturing are ensuring the quick, safe, and sterile transfer of fluids and not forgeting that every transfer needs to be ... more »

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