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April 1, Vol. 26, No. 7

  • Feature Articles

    • Biotechnology's Mid-Caps Post Solid Gain
    • In the relatively quiet month of February, the biotech industry managed to outperform the markets with the Burrill Biotech Select Index up 45%, while the NASDAQ finished down 1% and the Dow up 1% In addition, the biotech industry reached ... more »
    • Commercial Amounts of Purine Nucleosides
    • Sophia Fox
    • Metkinen Chemistry (wwwmetkinenchemistrycom) recently unveiled a biotransformation technology that, the company says, has enabled for the first time the cost-effective commercial production of purine nucleoside analogues for use in the development of oligonluceotide therapeutics and for research applications... more »
    • Nanobiotech in Genomics and Proteomics
    • Nanotechnology is the creation and utilization of materials, devices, and systems through the control of matter on the nanometer-length scale, ie, at the level of atoms, molecules, and supramolecular structures It is the popular term for the construction and utilization ... more »
    • Technical Note: Highly Sensitive qRT-PCR from On...
    • Ideally, gene expression studies by quantitative RT-PCR (qRT-PCR) should be performed using RNA from homogeneous cell populations Frequently, this means performing qRT-PCR using picogram amounts of total cellular RNA and, in some instances, using total RNA from a single cell... more »
    • Lean and Six Sigma Approaches Taking Hold
    • Angelo DePalma, Ph.D.
    • The successes of Six Sigma, Lean, and similar operational excellence strategies are legendary in heavy manufacturing Pharmaceutical and biotech companies were slow to catch on, but today, nearly every company has jumped on the bandwagon &#8220Most firms have entire departments ... more »
    • Characterization of Biologicals Is Advancing
    • The concept of well-characterized biologicals originated with the FDA Center for Biologics Evaluation and Research (CBER), which first employed the term in 1996 Prior to 1996, CBER required both a Product License Agreement (PLA) and an Establishment License Agreement (ELA) ... more »
  • Columns

    • Emerging Biopharmaceutical Companies
    • The 2005 bull market in biotechnology stocks continued to run through the end of February Biotech stocks tend to do well in the November&#8211February time frame, and 2006 has great momentum so far Driving this strength are a number of ... more »
    • Genta Seeks Therapeutic Product Approval
    • Ten years after starting the first human trials of its lead anticancer drug Genasense (oblimersen sodium injection), Genta (wwwgentacom) is seeking marketing approval for the treatment of patients with relapsed or refractory chronic lymphocytic leukemia (CLL) when Genasense is given ... more »
    • Medical Science Liaisons in Biotech
    • Last December, an article in this publication listed medical science liaisons (MSLs) among the hot jobs in biotechnology&#8217s transition from R&D-focused activity to commercialization (see Employment Trends in the Biotech Industry, GEN, December 2005) We were delighted to read this, ... more »
    • Patent Litigation: Is it Worth the Expense?
    • Tech-savvy companies know that successful enforcement of intellectual property rights and, particularly, patent rights can offer substantial rewards In the US patents represent a constitutionally granted monopoly to exclude others from using an invention, and whether through judgments, settlements, license ... more »
  • Tutorials

    • Assay: Protein Production for Structural Analysi...
    • Elucidation of protein structure and function maintains an important role in post-genomic sequencing and analysis studies An efficient protein production system is critical for obtaining large amounts of correctly folded recombinant protein for study Escherichia coli, or E coli, expression ... more »
    • Streamlining Pharmacogenetic Analysis
    • The National Center for Biotechnology Information determined that in 1994 there were over 22 million cases of adverse drug reactions in the US Adverse drug reactions, which are rooted in individuals&#8217 variable responses to medication, are a major cause of ... more »
    • Thermal Welding for Sterile Connections
    • Disposable process equipment demands reliable and fast sterile connecting devices Two of the important issues in disposable manufacturing are ensuring the quick, safe, and sterile transfer of fluids and not forgeting that every transfer needs to be disconnected after use... more »