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March 1, Vol. 26, No. 5

  • Feature Articles

    • M&As as Important Development Tools
    • The corporate merger (combining two businesses into one, usually by means of the initiating company paying for the transaction with its shares so that the shareholders of the target are now part-owners of the combined entity) or acquisition (the combination ... more »
    • Corporate Profile: Beckman Removes Divisional Ba...
    • Beckman Coulter (wwwbeckmancoultercom) has just completed a restructuring that is pulling down the divisional walls between biomedical research and clinical diagnostics, says Jeff Chapman, business manager, proteomics The changes are expected to create an environment where new technologies will move ... more »
    • Clearing the Target Validation Bottleneck
    • The target validation step of the drug discovery process aims to prove that a given target is directly involved in disease and can be used for development of a therapeutic drug Validation of a target requires collection and comprehension of ... more »
    • LabAutomation 2006 Final Recap
    • More than 4,000 people gathered for LabAutomation 2006 as the Association for Laboratory Automation brought its 10th annual conference back to Palm Springs Held at the end of January, the conference was, as usual, replete with new product introductions... more »
    • Protein Arrays as Key Discovery Tools
    • Drug development is such a formidable challenge that, some believe, it can only be undertaken effectively by big pharma Time-consuming and expensive, the classic approach has been to screen vast numbers of low molecular weight compounds for efficacy in blocking ... more »
    • HPLC Undergoes Slow, Steady Evolution
    • Angelo DePalma
    • For more than 20 years, the ongoing evolution of high-performance liquid chromatography (HPLC) has been a constant reminder of how intimately scientific progress depends on analytic technology HPLC has kept up with the complexity of biological investigations and in many ... more »
    • QA/QC for Viral Clearance
    • Gail Dutton
    • Viral clearance processes and the issues surrounding them are becoming more sophisticated but, as yet, few clear trends are emerging However, industry experts are noting some currents and eddies that are beginning to swirl around the issue... more »
    • Purification Woes Upstage Upstream Gains
    • New technologies in upstream biopharmaceutical production continue to increase yields and protein product quantities at the bioreactor However, these higher titers, larger yields, and shorter production times are not always making it through as end-product... more »
    • ELN and LIMS Aid Biotechnology Growth
    • Paper documentation of data and processes, which has been integral to R&D labs for years continues to be a widely used tool for data capture and analysis, recording important inventions and archiving information... more »
  • Columns

    • Finding a Balance in Assessment of Risk
    • Today the problem of deciding the case for approval is fraught with intense yet supposedly unknowable perils The FDA and other regulatory agencies globally struggle with ambiguities that typify the review process for routine submissions to the extent that these ... more »
    • Pitfalls in Patenting of Biomolecules
    • Patents have always been an important tool for pharmaceutical and biotechnology companies to protect their biopharmaceutical products from competition The composition patents for many basic biopharmaceutical products have expired or will expire soon, and as the market for biopharmaceuticals continues ... more »
    • M&As as Important Development Tools
    • The corporate merger (combining two businesses into one, usually by means of the initiating company paying for the transaction with its shares so that the shareholders of the target are now part-owners of the combined entity) or acquisition (the combination ... more »
  • Tutorials

    • Achieving Low-Volume Liquid Handling
    • Incorporating new liquid-handling technologies into the drug discovery process has been key to keeping pace with the demands for ever-increasing throughput and lower costs Systems must be designed to cope with the sheer number of assays and novel chemical entities ... more »
    • Cell-Based Assays for Study of GPCRs
    • G-protein-coupled receptors (GPCRs) are among the most successful targets for drug discovery research They represent the largest family of cell surface receptors with approximately 400 in the druggable genome GPCRs are essential in the transmission of a diverse assortment of ... more »
    • Choosing & Scaling Up Right Filter Combo
    • Filter train selection and scaling trials with small-scale flat-disc composites have become routine Such trials are often used to evaluate the optimal filter combination, polymer, and required retentivity However, trials performed with a low effective filtration area (EFA) and without ... more »