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February 1, Vol. 26, No. 3

  • Feature Articles

    • Biolog Advances Global Cell Analysis Scans
    • The quest to globally scan cellular functions started in the 1970s with the invention of 2-D gel electrophoresis, which allowed researchers to measure levels of most proteins in the cell and track how these levels change under different growth conditions ... more »
    • Drug Discovery and Development in India
    • Outsourcing part of a drug discovery program from a US pharmaceutical company to an Indian company can save up to $200 million on development costs, claimed David Hawkins, PhD, a consultant at UK Trade and Investment (wwwuktradeinvestgovuk), the UK governments ... more »
    • Extracting Compounds for Diverse Disciplines
    • Solid-phase extraction (SPE) can be used to capture almost any compound of interest for further analysis or to capture an impurity to maintain the quality of that which remains in the sample First used in environmental applications, SPE has found ... more »
    • Technical Note: Relieving the HTS Bottleneck for...
    • The central role of protein kinases in signal transduction and recent clinical success with small molecule kinase inhibitor drugs, most notably Gleevec (Novartis), have generated intense interest in kinase enzymes as therapeutic targets1 Next to G-protein coupled receptors, protein kinases ... more »
    • Optimizing High-Throughput Screening
    • The high-throughput screening (HTS) arena has been a hotbed of technological advances over the past few years The ability to synthesize huge chemical libraries and the availability of automated robots to assist in the screening process has enabled drug development ... more »
    • Improving Gene Expression Analysis
    • The development of microarrays launched gene expression profiling on to a new level However, the biggest challenge in microarray research today is data quality Concerns voiced by those in the industry have prompted the development of new technologies and methods ... more »
  • Columns

    • Wake-up Call for U.S. Innovation
    • When it comes to innovation in science and technology, the US has been the recognized global leader since the end of World War II Today, however, that No 1 position is in jeopardy as many foreign governments strengthen their educational ... more »
  • Tutorials

    • Planning, Documentation, and Collaboration
    • Todays demanding drug discovery environment requires close collaboration within and between multidisciplinary groups of scientific teams and necessitates that individual research efforts are maximally leveraged These teams need access to experimental work and results in real-time, while individual team members ... more »
    • Multiplex Transcription Factor Profiling
    • Marligen Biosciences (www marligencom) has developed assays that allow researchers to study the activation of up to 30 transcription factors (TFs) in a single sample Profiling the activation of multiple TFs in response to different stimuli aids in the analysis ... more »
    • Testing & Validation of Disposable Systems
    • In Bioprocess Technology Consultants (wwwbioprocessconsultantscom) third annual survey of biopharmaceutical manufacturing capacity and production, biopharmaceutical manufacturers and CMOs said the primary reason they werent expanding the use of single-use disposables was concern over how to validate single-use systems in relation ... more »