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Jan. 1, Vol. 26, No. 1

    • Point of View

      • Policymakers Should Harness User Fees for Drug Safety
      • In the wake of the Vioxx debacle, physicians and consumers alike have lost confidence in the FDA's ability to ensure patient safety. And no one can blame them. Since Vioxx, nothing has really changed. The FDA continues to review drugs before th ... more »
    • Legal Affairs

      • Gene Patents and Global Competition Issues
      • In 1980, the United States Supreme Court, in Diamond v Chakrabarty, 447 U.S. 303 (1980), found "anything under the sun that is made by man," including genetically altered microorganisms, to be patentable subject matter. At about the same ... more »
    • Feature Articles

      • Applying Biomarker Discovery Strategies
      • With the human proteome comprising 10 times more proteins than there are genes in the genome, the complexity of proteomics research and the efforts under way to identify and characterize protein biomarkers of disease and translate those findings int ... more »
      • Cell Culture Advances Enable Better Biology
      • Two main forces are driving the cell culture marketplace, according to some industry observers. "Improving the user's experience and creating better biology," is how Martin Naley, director of the business segment for cell culture resea ... more »
      • Correlating Genomics, Race, and Medicine
      • Gail Dutton
      • Results from the Human Genome Project and the cataloging of human genetic variation are spurring discussions that may turn modern concepts of race on their ears. The latest word is that, "among modern humans, there's no such thing as race,& ... more »
      • Establishing QC for Molecular Diagnostics
      • Joan Gordon and Clark Rundell, Ph.D., know the importance of controls in clinical laboratory testing, having both worked in the clinical laboratory at the Maine Medical Center in Portland, the state's largest healthcare facility. When running a ... more »
      • French Biotech Hungers for Fiscal Stimuli
      • In a letter dated November 7, 2005, the biotechnology association, France Biotech (Paris) prompted the French Prime Minister and other ministers, senators, and deputies, for enactment of its finance proposal for the listing of young innovative compa ... more »
      • Measurement of a Communications Program
      • Gauging return on investment on a corporate communications campaign is almost as challenging as conceptualizing the underlying creative strategy. With budgets under continuous scrutiny, communications departments are often under intense pressure to ... more »
      • New Tools Highlighted at ASHG Conference
      • Several companies introduced new tools for advancing genomics research at the "55th Annual Meeting of the American Society for Human Genetics," held recently in Salt Lake City. The offerings are expected to help to stimulate genomics studi ... more »
      • RNAi Technologies Become Discovery Staple
      • As companies continue to develop assays and software to improve RNAi screening and data analysis, more applications of this assay are being discovered. Some of these potentially include toxicity and ADME assays, enhancing therapeutic potency, and hi ... more »
      • Toxicogenomics Enhances Drug Discovery
      • Kathy Liszewski
      • Adverse health effects resulting from drug toxicity reactions are invariably associated with alterations in gene expression. Toxicogenomics aims at interrogating such changes with the hope of better hazard identification and risk assessment. Microa ... more »
    • Tutorials

      • Effective GPCR Screening Using ERK 1/2
      • G protein-coupled receptors (GPCRs) represent a diverse group of signaling proteins and are involved in a wide variety of physiological processes. Of particular importance to the pharmaceutical industry, GPCRs, for the most part, have proved amenabl ... more »
      • Maximizing Quality in HTS Kinase Screening
      • Protein kinases are enzymes that transfer a phosphoryl group to serine, threonine, or tyrosine side chains of a target protein, thereby changing its activity. Dysregulation of protein kinases has been implicated in many types of cancer and also infl ... more »
      • Taking the Guesswork Out of Production
      • Can our existing labor force handle a 20% increase in production? If the ultrafiltration step takes four hours longer than usual, how can the remaining process steps best be rescheduled to avoid interfering with the next batch? Does the flexibility ... more »

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