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Aug. 1, Vol. 25, No. 14

    • Columns

      • Asia Offers Opportunities in Pharmaceuticals
      • Asias impact on the global biotechnology and pharmaceutical industry is accelerating. From quality supply of active pharmaceutical ingredients (APIs) to discovery of new chemical entities (NCEs), this sector is finally coming of age. The challenge, ... more »
      • Safe Harbor Provisions for Preclinical Research
      • On June 13, 2005, in Merck KGaA v. Integra LifeSciences I, Ltd., the U.S. Supreme Court made clear in a unanimous opinion that broad immunity from patent infringement exists for preclinical research and experimentation reasonably related to the proc ... more »
    • Feature Articles

      • Bioresearch Highlights Significance of SNPs
      • Scientists have been analyzing SNPs and their role in disease for several years. Mapping of the human genome revealed that these single nucleotide alterations are responsible for not only our phenotypic traits, but also how we respond to medicine an ... more »
      • Disposable Bioreactors Become Standard Fare
      • Increasingly users of traditional bioreactor and fermentor systems are looking to integrate disposable reactors and system components, or even make the switch to completely disposable systems in order to minimize the need for complex cleaning, steri ... more »
      • Drug Delivery Technology: Deals and Advances
      • Drug delivery technology (DDT) is increasingly important as a component of drug development. An FDA survey found that only 9% of the 99 new small molecule drugs introduced between 1995 and 2001 were Class I high solubility and permeability, which fa ... more »
      • Innovative Antibody Products and Therapeutics
      • At a recent CHI meeting in Cambridge, MA, "Recombinant Antibodies from Concept to Clinic", a wide range of new antibody technologies were covered. Dana Ault-Rich, Ph.D., CEO of Pointilliste (Mountain View, CA), discussed the company's ... more »
      • North Carolina Leads Southeast in Biotech
      • For the second straight year, North Carolina ranks third behind California and Massachusetts as a biotechnology powerhouse. In fact, North Carolina continues to be the "leading center in the Southeast for biotechnology," according to Ernst ... more »
      • Optimizing Strategies for Hit-to-Lead Process
      • The main challenge in the process of taking a hit to a lead in drug discovery is figuring "what questions to ask and what information will best help focus lead optimization," said Simon Hirst, Ph.D., CEO of Sygnature (Nottingham, U.K.), as ... more »
      • Twists and Turns on the Path to Find New Drugs
      • With a wealth of revolutionary technologies in hand, pharmaceutical developers today don't leave much to chance. But as luck would have it, serendipity did play a large role in drug discovery in the past. The story of warfarin, the most widely ... more »
    • Tutorials

      • Animal-Derived Agents in Disposable Systems
      • Polymeric materials have been widely used in bioprocessing for more than a decade. Disposable processing products manufactured from plastic materials include flexible tubing, sanitary fittings, cylindrical tanks, carboys, powder-handling bags, capsu ... more »
      • Automating True Manual Patch Clamping
      • The pharmaceutical industry has widely recognized patch clamping as the "gold standard" to provide the highest information content in the drug discovery screening process by directly measuring the current passing through ion channels. This ... more »
      • New Tool for Metabolic Disease Research
      • Defects in fatty acid metabolism have been linked to several pathological states, including insulin desensitization, Type 2 diabetes, obesity, and cardiovascular disease. Specifically, uptake of long chain fatty acids (LCFAs) plays an important role ... more »

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