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June 15, Vol. 25, No. 12

  • Feature Articles

    • Applying Nanotech to Materials Research
    • Gail Dutton
    • Nanotech, the manipulation of individual molecules to produce materials with new and unique structural properties, is poised to become a major force in advanced materials research that will affect areas of research as diverse as drug delivery, electronics, and even ... more »
    • PCR Gains Momentum with New Applications
    • PCR turns twenty this year, dating from its invention in 1985 by Kary B Mullis Since then, applications and adaptations of PCR have proliferated The advent of real-time PCR couples a modified thermocycler with real-time kinetics, for a highly accurate ... more »
    • High Demand for Target Validation Technologies
    • The various methods used in target validation were the focus of discussion earlier this month at two separate meetings held in Boston and a third meeting in Singapore The Boston meetings included the "IBC USA Early Efficacy Assessment Meeting" and ... more »
    • Using Complexity to Enhance Drug Discovery
    • Participants in Cambridge Healthtech's conference, "Systems Biology: Validation of Multi-Variate Biology," held recently in San Francisco, described multiple approaches to putting biology back into drug discovery and development as well as extending it to predictive medicine... more »
    • Research Options for Structural Proteomics
    • Gail Dutton
    • Not so long ago, structural proteomics research was divided into two distinct campsx-ray crystallography and NMR spectroscopy X-ray crystallography remains the gold standard for structural determination, but NMR capabilities are proving their value for proteins that can't be crystallized and ... more »
    • Can India's IT Success be Replicated in Biotech?
    • Active support from the Indian government for increased funds and infrastructure, such as biotech parks, as well as an emphasis on R&D, will help strengthen India's biotech sector in the near future, according to MK Bhan, MD, secretary, department of ... more »
  • Tutorials

    • Taking Computational Biology to the Bench
    • Discovery is challenged by constantly changing data requirements and increasing analytics complexity More and more labs need flexible informatics with less programming New informatics software, called experiment design automation (XDA), can help labs improve the speed and quality of experimentation ... more »
    • Miniaturized Filtration Assay for Discovery
    • A major focus in drug discovery involves the identification of compounds that reduce or modulate biological processes by altering the activity of cellular receptors or signal transduction components such as kinases Located in the cell membrane, the cytoplasm, or the ... more »
    • Evaluation of the CellFerm-Pro STBR System
    • Improved process development technology can positively impact process development outcomes in three ways First, process development technology with increased throughput allows the evaluation of more process conditions, increasing the probability of finding superior culture processes... more »