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June 1, Vol. 25, No. 11

  • Feature Articles

    • Greater Philly Region Grows as a Bio Cluster
    • BIO's annual conference, which will be held in Philadelphia later this month, highlights the fact that Southeastern Pennsylvania represents a significant focus of biotech and pharmaceutical activity Indeed, recent developments reinforce the area's prominence as a center of drug development ... more »
    • Functional Genomics Reveals Mysteries of Genes
    • Many companies are shifting their focus from genome mapping and sequencing to determining gene function Functional genomics uses a range of technologies for genome-wide analyses supported by data interpretation These activities depend on experimental and computation methods... more »
    • Ways to Overcome the Small Molecule Curse
    • Oral bioavailability, access to intracellular targets, and cost and ease of production are a few advantages that small molecule drugs generally have over large molecule drugs such as biologics, natural products, and peptides These properties make small molecule drugs highly ... more »
    • Trends in Incubator and Shaker Technologies
    • Preventing contamination using thermal decontamination routines and the upcoming use of oxygen control could be seen as trends in incubation, according to Rainer Zagst, product marketing manager of Kendro Laboratory Products (www kendrospxcom) The biggest problem in incubation is the ... more »
    • Oligo Manufacturing Puts Emphasis on RNA
    • As more experimental DNA drugs move through the clinic and into large-scale trials, the demand for efficient and cost-effective manufacturing strategies is intensifying Higher yields, greater purity, and lower production costs are the key drivers of new DNA synthesis technology ... more »
    • Mass Spectrometry in the Life Science Market
    • Though originally employed in academic exercises during the early part of the last century to characterize the masses and determine the stabilities of nuclear isotopes, the practicality of mass spectrometry (MS) was quickly realized... more »
  • Columns

    • Examining NIH Policy to Enhance Public Access
    • The increased public access policy to be effected by the National Institutes of Health (NIH) was originally conceived to change the way patent practioners interact with inventors of biologically or chemically based inventions After receiving public comments on the proposed ... more »
    • Anti-Cancer Therapy Success
    • John Wong
    • Genentech (San Francisco) had a banner year from 1997 to 1998, when it received FDA approval to market its two monoclonal antibodies for treating cancers In November 1997, Genentech received FDA approval to commercialize Rituxan (rituximab), to treat B-cell non-Hodgkin ... more »
  • Tutorials

    • Applying PAT to Oligonucleotide Synthesis
    • Oligonucleotides are short strands of DNA or RNA that play a major role in drug discovery and molecular diagnostic chip technology They are used from initial research and screening through to target validation and drug production... more »
    • Microarray Data Management and Analysis
    • In microarray gene expression experiments, several diverse conditions in each experiment (eg, time, doses, replicates) increase the data points from tens of thousands of measurements for a single array to millions for the experiment as a whole... more »
    • Integrated Workflow for Development Testing
    • In response to the realization that many products have failed due to formulation issues, pharmaceutical companies are putting much more emphasis on achieving optimal product formulations earlier in the development process Using traditional manual experimental methods there is often only ... more »