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July 1, Vol. 34, No. 13

  • Feature Articles

    • Whole-Exome Sequencing in Clinical Practice
    • Kevin Mayer
    • Although whole-exome sequencing (WES) has its limitations, particularly with respect to secondary or incidental findings, it may still shine in routine clinical care, particularly if testing is contingent on specific indications and focuses on primary findings That is, WES, applied ... more »
    • Single-Cell Analysis Reveals New Horizons
    • Richard A. Stein
    • Historically, the vast majority of experimental studies that have scrutinized biological phenomena have done so by surveying populations of cells While it is expedient, this approach has a significant shortcoming—it yields measurements that reflect population averages Such measurements say little ... more »
    • RNA-Seq Dissects the Transcriptome
    • Kathy Liszewski
    • With the rapid rise of next-generation sequencing (NGS), one of its technologies, RNA sequencing (RNA-Seq), has taken center stage for analyzing whole transcriptomes Although RNA-Seq is still the new kid on the block, this technology, its proponents say, could revolutionize ... more »
  • Columns

    • Eppendorf Absorbs New Brunswick Scientific
    • Gail Dutton
    • New Brunswick Scientific, a developer of bioprocessing equipment for fermentation and cell culture growth and storage, has been a part of Eppendorf AG since 2007 Only recently, however, has New Brunswick become fully integrated into Eppendorf At the end of ... more »
    • Drug R&D: Big Data for Big Returns
    • Todd Skrinar
      Thaddeus Wolfram
    • Cost pressures and new pay-for-performance payer approaches are making demonstration of real-world outcomes as essential to the drug research and development (R&D) model as initial, premarket evidence Tied to this trend R&D organizations have an opportunity to improve productivity using ... more »
    • Rediscovering Therapeutic Peptides
    • Therapeutic peptides constitute an unusual drug category Although most therapeutic peptides are synthetic, their molecular weights are well above those of small-molecule drugs, but well below those of proteins Like other peptides, therapeutic peptides use amino acid building blocks ... more »