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January 1, Vol. 34, No. 1

  • Feature Articles

    • Advances in Protein Expression
    • Angelo DePalma, Ph.D.
    • Approximately half of approved recombinant biotherapeutics are expressed in Escherichia coli During downstream processing, it is necessary to remove the organism’s outer membrane, which consists of lipopolysaccharide (LPS), also known as endotoxin... more »
    • Orchestrating CRO Services
    • Jeanene Swanson
    • The drug development process is vast, involving a nearly symphonic coordination of many disparate players—trial sponsors, contract research organizations (CROs), and institutions such as academic medical centers and hospitals... more »
    • Predictive In Vitro Assay Trend Grows
    • MaryAnn Labant
    • Lack of safety or efficacy continues to impact the failure rate for compounds entering clinic trials, implying that the current preclinical decision-making paradigm is not sustainable Animal models and commonly used in vitro assays are simply not predictive of human ... more »
  • Columns

    • Asthma Prescription Numbers Slow Down
    • Gail Dutton
    • The asthma prescription market is slowing as the leading drugs lose patent protection But leading market researchers BCC and GBI Research each predict moderate growth until at least 2017, thanks to new market entrants and a disease prevalence that continues ... more »
    • Alternatives to Animal Testing Drive Market
    • Robert G. Hunter
    • Traditional in vivo animal methods for assessing safety and toxicity continue to be replaced by alternative methods: in vitro and in silico In addition, these alternatives are evolving into key technologies, practices, and resources for future medical applications in efficacy ... more »
    • Traditional Instrument Maker Stays Nimble
    • Gail Dutton
    • Moore’s Law says, roughly, that processing power doubles every two years While physicists say we’re pushing the limits of that law now, the point remains that scientific advances are increasing at an accelerating pace and that analytical instrument makers must ... more »