Point of View

• Anti-GE Activism: Will It Ever End?
  
• Henry I. Miller, M.D.
• Robert Macgregor
• More than 400 million acres of genetically engineered (GE) crops have been grown in more than three dozen countries around the world. Plants produced in this way—also known as “genetic modification,” or GM—constitute the most rapidly adopted agricul ... more »
  

Corporate Profiles

• Cytomics for Personalized Heart Health
  
• Carol Potera
• CytoVas aims to improve the assessment of cardiovascular health. The early-stage, in vitro diagnostic company is working to improve its Vascular Health Profile (VHP). Based on cytomics, which analyzes cell systems and networks, VHP is a blood test t ... more »
  

BioMarket Trends

• Exosome Research Publication Landscape
  
• Gary Oosta, Ph.D.
• Jeff Fan
• Exosome research is growing exponentially as researchers from several disparate disciplines are exploring the role of exosomes in inter-cellular communication, immunological responses, stem cell behavior, cancer cell communication, etc. Indeed, the ... more »
  

People in the News

• People in the News
  
• Conkwest hired Hans Klingemann, M.D., Ph.D. , as CMO and CSO. Dr. Klingemann is a member of the board for Osiris Therapeutics. Previously, he was professor of medicine and director, bone marrow and stem cell transplant program at Tufts Medical Cance ... more »
  

Feature Articles

• Exploring GPCRs as Therapeutic Targets
  
• Caitlin Smith
• Recent years have seen an explosion of disease-relevant research on G-protein coupled receptors (GPCRs). Hot topics include strategies for targeting GPCRs therapeutically, and understanding the mechanisms of biased agonism. A number of distinguished ... more »
  

Tutorials

• Library Format for Bioengineering
  
• Brett Levay-Young
• Melanie Olesiuk
• Claes Gustafsson, Ph.D.
• Jeremy Minshull, Ph.D.
• Proteins with desirable properties are often identified by screening libraries of related gene sequences. Successful applications include antibody engineering, vaccine development, and biocatalyst optimization. Properties as diverse as thermal stabi ... more »
  

Feature Articles

• Advances in RNAi Tools and Technologies
  
• Thalyana Smith-Vikos
• RNAi research has capitalized on the ability to design and deliver small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) to knock down expression of target genes with strong selectivity and specificity. These genetic tools have applicatio ... more »
  

Tutorials

• Hand-Held Homogenization Tool
  
• Horacio Kido, Ph.D.
• One of the largest bottlenecks in a modern life science laboratory workflow is at the beginning of the sample-preparation stage: It is the efficient lysis, homogenization, and grinding of difficult-to-lyse samples. This step is necessary in order to ... more »
  

Feature Articles

• Boosting Downstream Productivity
  
• MaryAnn Labant
• In 2012, BioPlan Associates estimated the global market for biopharmaceuticals at $140 billion, of which $100 billion was for recombinant proteins. The monoclonal antibody (mAb) market, a subclass of recombinant proteins, was estimated at $40 billio ... more »
  

• Single-Use Bioreactor Roundup
  
• A number of bioprocess analysts estimate that the entire single-use market has been growing at about 15–20% per year. Single-use bioreactors (SUB), in particular, are rapidly increasing in popularity and seem destined to stay. GEN polled a number of ... more »
  

Tutorials

• Adjusting pH During Viral Inactivation
  
• Joe Makowiecki
• Heather Mallory
• Low pH inactivation is commonly used in monoclonal antibody purification processes to inactivate large enveloped viruses. Adjusting the pH to achieve this as part of a single-use biomanufacturing workflow usually requires manual manipulation of the ... more »
  

Corporate Capabilities

• Advertorial: AAIPharma Services
  
• AAIPharma Services is a highly experienced provider of drug development, manufacturing, and analytical services to the pharmaceutical, biotech, and healthcare industries. For over 33 years, AAIPharma has been a leading provider and has grown into a ... more »
  

• Advertorial: ACEA Biosciences
  
• The year 2013 marks a significant milestone for ACEA Biosciences as the company celebrates its 10th anniversary. Over the course of the last decade ACEA has transformed itself from a small startup company to a leading provider of instrumentation for ... more »
  

Feature Articles

• Pathway Analysis to Decipher Data
  
• Rhea U. Vallente, Ph.D.
• The generation of high-throughput data from sequencing and gene expression profiling experiments has resulted in an overabundance of information, making analysis quite overwhelming. Pathway analysis offers an approach that involves grouping thousa ... more »
  

• Stockholm-Uppsala Region Ups the Ante
  
• Tamlyn Oliver
• Putting neighboring-city rivalries aside, government agencies and the life science communities in Stockholm and Uppsala, Sweden, have joined forces with plans to create an internationally renowned life science cluster. The region is boldly ambitious ... more »