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Oct. 15, Vol. 32, No. 18

BioBusiness
- Point of View
  - Patient Safety Top Concern with Biosimilars
  - Donald J. Palmisano, M.D., J.D.
  - From the discovery of the polio vaccine to the first successful heart transplant, Americans have always had the benefits of cutting-edge medicine. Today, we stand on the threshold of yet another major advancement that could open the door to providin ... more »
- Corporate Profiles
  - Capitalizing on Down-to-Earth Discovery Tools
  - Carol Potera
  - “Natural products have always played a role in drug discovery,” says Dietmar Wolf, Ph.D., executive vp of AnalytiCon Discovery. In fact, about half of all small molecule drugs on the market are derived from natural products or their synthetic analog ... more »
- BioMarket Trends
  - Epigenomics Infiltrates Cancer Treatment
  - K. John Morrow Jr., Ph.D.
  - As is often the case in the history of science, observations that do not agree with the dominant paradigm are swept under the rug until they build up to the point where they can no longer be ignored. So was the case with epigenomics. Written off a ... more »
- People in the News
  - People in the News
  - Chembio Diagnostics hired Sharon Klugewicz as vp of quality assurance/quality control and technical operations. Previously, she was svp, scientific and laboratory services at Pall and also held positions in the Pall Life Sciences division in marketi ... more »
Drug Discovery
- Feature Articles
  - Biomarkers Inform Cancer Research
  - John Russell
  - Biomarkers—the essential fuel for personalized medicine—play an ever-growing role in drug discovery, clinical development, and, at least for cancer, in the clinic where genomic profiling of individual tumors often informs therapy selection. Advanc ... more »
- Tutorials
  - Identifying Sialic Acids in Glycoproteins
  - Jeffrey Rohrer, Ph.D.
  - Deanna C. Hurum
  - Sialic acids, also referred to as neuraminic acids, are critical to glycoprotein bioavailability, function, stability, and metabolism. When present, these carbohydrates occupy terminal positions of oligosaccharides in glycosylated proteins, providin ... more »
- Tech Notes
  - Pathogen and Cancer Biomarker Genotyping
  - Thomas Froehlich, Ph.D.
  - This article describes three gene-analysis studies using the Roche LightCycler® 1536 Real-Time PCR System ( Figure 1 ). In the first featured study, French researchers used high-throughput real-time PCR to test for the bacterial subtypes respon ... more »
OMICS
- Feature Articles
  - RNA Analysis Unearths Invaluable Insights
  - Richard A. Stein, M.D., Ph.D.
  - RNA has emerged as one of the most fascinating molecules in biology. As the Human Genome Project revealed that the number of genes in humans, lower than predicted, is comparable to that from Arabidopsis thaliana and Caenorhabditis elegans , and alte ... more »
- - Sequencing Hones In on Targets
  - Greg Crowther, Ph.D.
  - As next-generation sequencing (NGS) transforms biomedical research, industrial and academic scientists continue to improve the efficiency of their sample-preparation and data-filtering techniques. One of the main challenges is that of target enric ... more »
- Tutorials
  - Isolating Intact Pathogens from Tissues
  - Elizabeth K. Marsh
  - Robin C. May
  - Esmeralda Carvalho
  - Determining the internal pathogen burden of tissues and animals is an important component of infectious disease research. Yet the disruption of these tissues in order to release an intact, viable pathogen for quantification or further experimentatio ... more »
- Assay Tutorials
  - New Method for “Fingerprinting” Biosimilars
  - Michael Davies
  - Xing Wang, Ph.D.
  - Recent healthcare legislation in the U.S. has created a pathway for biosimilar approval and commercialization, potentially unleashing a wave of competition to the current class of blockbuster biologics now on the market. However, reconciling the dev ... more »
Bioprocessing
- Feature Articles
  - Confronting Scaleup Challenges Head On
  - Angelo DePalma, Ph.D.
  - Despite new heights of process characterization and knowledge, scaleup still can befuddle the most experienced of bioprocessors. Wei Chen, Ph.D., chief scientist at Phage Pharmaceuticals, believes that a disconnect between early-stage R&D and ... more »
- Tutorials
  - CO₂ Measurement in Microfluidic Devices
  - Christopher Long, Ph.D.
  - Wesley Anderson
  - Craig Finch, Ph.D.
  - James Hickman, Ph.D.
  - The reliable, noninvasive measurement of dissolved gases in microfluidic devices is an important and difficult activity for biological applications. The PreSens pCO 2 mini and chemical optical CO 2 sensors have been designed to noninvasively measure ... more »
Translational Medicine
- Feature Articles
  - Marching Toward a “Cyber War” on Cancer
  - Alex Philippidis
  - In The Art of War , Sun Tzu advises, “Know your enemy and know yourself and you can fight a hundred battles without disaster.” As the federal “war on cancer,” slogs on toward its 42nd year in December, researchers from Israel and the U.S. have app ... more »
- - Synergy Holds Key in Molecular Diagnostics
  - Kathy Liszewski
  - PCR continues to revolutionize molecular diagnostics. Its ability to enrich genomic regions of interest for next-generation sequencing (NGS) and interface with other technologies such as mass spectrometry are helping move the field closer to the goa ... more »