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June 1, Vol. 32, No. 11

  • Columns

    • People in the News
    • EMD Millipore promoted Andrew Bulpin, PhD , to head of global pharmaceutical chemicals solutions sales Dr Bulpin joined Millipore in 2006 as vp for the upstream processing business unit and assumed leadership of the services and solutions business in January ... more »
    • Keeping Cell Cultures Contamination Free
    • Carol Potera
    • Bioprocessing operations face the threat that bacteriophages (viruses that infect bacteria) will infect the cell cultures used to manufacture biotherapeutic proteins in bioreactors Contamination with bacteriophages, also known as phages, may completely paralyze an operation and even cause a shortage ... more »
    • Outsourcing Discovery Can Stretch Dollars
    • Bruce Carlson
    • Outsourcing has become so paramount to a pharmaceutical firm’s strategy that it is a given that noncore functions will be outsourced Core functions, however, like the discovery of potential new drugs, used to remain in house This pattern has been ... more »
    • Gene Therapy Briefs
    • Amsterdam Molecular Therapeutics (AMT) lost its appeal to EMA’S Committee for Medicinal Products for Human Use (CHMP), which maintained a previous recommendation that the company’s gene therapy Glybera® (alipogene tiparvovec) should not be granted marketing authorization in Europe for lipoprotein ... more »
    • Advertorial: DSM Pharma Biotechnology
    • Our main focus at DSM is to create brighter lives for people today and for generations to come DSM Pharmaceutical Products is a leading pro­vider of high-quality custom contract manufacturing, development services, and optimizing technologies to the pharmaceutical, biopharmaceutical and ... more »
  • Tutorials

    • Mass Spec Analysis of Intact Membrane Proteins
    • Robert Gates
    • Detailed elucidation of protein structure and function typically requires removal of the protein from its in vivo environment However, applying traditional and detergent-based protein extraction and purification workflows to membrane proteins typically produces insoluble, inactive, and heterogeneous fractions despite various ... more »